M
Maiara S. Severo
Researcher at University of California, Riverside
Publications - 15
Citations - 652
Maiara S. Severo is an academic researcher from University of California, Riverside. The author has contributed to research in topics: Anaplasma phagocytophilum & Human granulocytic anaplasmosis. The author has an hindex of 8, co-authored 15 publications receiving 558 citations. Previous affiliations of Maiara S. Severo include Max Planck Society.
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Journal ArticleDOI
Genomic insights into the Ixodes scapularis tick vector of Lyme disease
Monika Gulia-Nuss,Monika Gulia-Nuss,Andrew B. Nuss,Andrew B. Nuss,Jason M. Meyer,Jason M. Meyer,Daniel E. Sonenshine,R. Michael Roe,Robert M. Waterhouse,David B. Sattelle,José de la Fuente,José de la Fuente,José M. C. Ribeiro,Karyn Megy,Karyn Megy,Jyothi Thimmapuram,Jason R. Miller,Brian P. Walenz,Brian P. Walenz,Sergey Koren,Sergey Koren,Jessica B. Hostetler,Jessica B. Hostetler,Mathangi Thiagarajan,Mathangi Thiagarajan,Vinita Joardar,Vinita Joardar,Linda Hannick,Linda Hannick,Shelby L. Bidwell,Shelby L. Bidwell,Martin Hammond,Sarah Young,Qiandong Zeng,Jenica L. Abrudan,Jenica L. Abrudan,Francisca C. Almeida,Nieves Ayllón,Ketaki Bhide,Brooke W. Bissinger,Elena Bonzón-Kulichenko,Steven D. Buckingham,Daniel R. Caffrey,Melissa J. Caimano,Vincent Croset,Vincent Croset,Timothy P. Driscoll,Timothy P. Driscoll,Don Gilbert,Joseph J. Gillespie,Joseph J. Gillespie,Gloria I. Giraldo-Calderón,Gloria I. Giraldo-Calderón,Jeffrey M. Grabowski,Jeffrey M. Grabowski,David Jiang,Sayed M.S. Khalil,Donghun Kim,Donghun Kim,Katherine M. Kocan,Juraj Koči,Juraj Koči,Richard J. Kuhn,Timothy J. Kurtti,Kristin Lees,Kristin Lees,Emma G. Lang,Ryan C. Kennedy,Hyeogsun Kwon,Hyeogsun Kwon,Rushika Perera,Rushika Perera,Yumin Qi,Justin D. Radolf,Joyce M. Sakamoto,Alejandro Sánchez-Gracia,Maiara S. Severo,Maiara S. Severo,Neal S. Silverman,Ladislav Šimo,Ladislav Šimo,Marta Tojo,Marta Tojo,Cristian Tornador,Janice P. Van Zee,Jesús Vázquez,Filipe G. Vieira,Margarita Villar,Adam R. Wespiser,Yunlong Yang,Jiwei Zhu,Peter Arensburger,Patricia V. Pietrantonio,Stephen C. Barker,Renfu Shao,Evgeny M. Zdobnov,Evgeny M. Zdobnov,Frank Hauser,Cornelis J. P. Grimmelikhuijzen,Yoonseong Park,Julio Rozas,Richard Benton,Joao H. F. Pedra,Joao H. F. Pedra,David R. Nelson,Maria F. Unger,Jose M. C. Tubio,Jose M. C. Tubio,Zhijian Jake Tu,Hugh M. Robertson,Martin Shumway,Martin Shumway,Granger G. Sutton,Jennifer R. Wortman,Daniel Lawson,Stephen K. Wikel,Vishvanath Nene,Vishvanath Nene,Claire M. Fraser,Frank H. Collins,Bruce W. Birren,Karen E. Nelson,Elisabet Caler,Elisabet Caler,Catherine A. Hill +124 more
TL;DR: Insights from genome analyses into parasitic processes unique to ticks, including host ‘questing', prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival are reported.
Journal ArticleDOI
Ixodes scapularis saliva mitigates inflammatory cytokine secretion during Anaplasma phagocytophilum stimulation of immune cells
Gang Chen,Maiara S. Severo,Mohammad Sohail,Olivia S. Sakhon,Stephen K. Wikel,Stephen K. Wikel,Michail Kotsyfakis,Joao H. F. Pedra +7 more
TL;DR: Findings suggest that I. scapularis saliva may inhibit inflammatory cytokine secretion during rickettsial transmission at the vector-host interface.
Journal ArticleDOI
The Tick Salivary Protein Sialostatin L2 Inhibits Caspase-1-Mediated Inflammation during Anaplasma phagocytophilum Infection
Gang Chen,Xiaowei Wang,Maiara S. Severo,Olivia S. Sakhon,Mohammad Sohail,Lindsey J. Brown,Mayukh Sircar,Greg A. Snyder,Eric J. Sundberg,Tyler K. Ulland,Alicia K. Olivier,John F. Andersen,Yi Zhou,Guo-Ping Shi,Fayyaz S. Sutterwala,Michail Kotsyfakis,Joao H. F. Pedra,Joao H. F. Pedra +17 more
TL;DR: It is shown that sialostatin L2 targets caspase-1 activity during host stimulation with the rickettsial agent Anaplasma phagocytophilum, and this finding is an important finding in inflammasome biology.
Journal ArticleDOI
The E3 Ubiquitin Ligase XIAP Restricts Anaplasma phagocytophilum Colonization of Ixodes scapularis Ticks
Maiara S. Severo,Anthony Choy,Kimberly D. Stephens,Olivia S. Sakhon,Gang Chen,Duk-Won D. Chung,Karine G. Le Roch,Gregor Blaha,Joao H. F. Pedra +8 more
TL;DR: A role for ubiquitination during bacterial colonization of disease vectors is defined and evidence that xiap silencing significantly increases tick colonization by the bacterium Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis is provided.
Journal ArticleDOI
Anaplasma phagocytophilum: deceptively simple or simply deceptive?
TL;DR: An overview of the underlying events by which the immune system responds to A. phagocytophilum infection, how this pathogen counteracts host immunity and the contribution of the tick vector for microbial transmission is provided.