Genomic insights into the Ixodes scapularis tick vector of Lyme disease
Monika Gulia-Nuss,Monika Gulia-Nuss,Andrew B. Nuss,Andrew B. Nuss,Jason M. Meyer,Jason M. Meyer,Daniel E. Sonenshine,R. Michael Roe,Robert M. Waterhouse,David B. Sattelle,José de la Fuente,José de la Fuente,José M. C. Ribeiro,Karyn Megy,Karyn Megy,Jyothi Thimmapuram,Jason R. Miller,Brian P. Walenz,Brian P. Walenz,Sergey Koren,Sergey Koren,Jessica B. Hostetler,Jessica B. Hostetler,Mathangi Thiagarajan,Mathangi Thiagarajan,Vinita Joardar,Vinita Joardar,Linda Hannick,Linda Hannick,Shelby L. Bidwell,Shelby L. Bidwell,Martin Hammond,Sarah Young,Qiandong Zeng,Jenica L. Abrudan,Jenica L. Abrudan,Francisca C. Almeida,Nieves Ayllón,Ketaki Bhide,Brooke W. Bissinger,Elena Bonzón-Kulichenko,Steven D. Buckingham,Daniel R. Caffrey,Melissa J. Caimano,Vincent Croset,Vincent Croset,Timothy P. Driscoll,Timothy P. Driscoll,Don Gilbert,Joseph J. Gillespie,Joseph J. Gillespie,Gloria I. Giraldo-Calderón,Gloria I. Giraldo-Calderón,Jeffrey M. Grabowski,Jeffrey M. Grabowski,David Jiang,Sayed M.S. Khalil,Donghun Kim,Donghun Kim,Katherine M. Kocan,Juraj Koči,Juraj Koči,Richard J. Kuhn,Timothy J. Kurtti,Kristin Lees,Kristin Lees,Emma G. Lang,Ryan C. Kennedy,Hyeogsun Kwon,Hyeogsun Kwon,Rushika Perera,Rushika Perera,Yumin Qi,Justin D. Radolf,Joyce M. Sakamoto,Alejandro Sánchez-Gracia,Maiara S. Severo,Maiara S. Severo,Neal S. Silverman,Ladislav Šimo,Ladislav Šimo,Marta Tojo,Marta Tojo,Cristian Tornador,Janice P. Van Zee,Jesús Vázquez,Filipe G. Vieira,Margarita Villar,Adam R. Wespiser,Yunlong Yang,Jiwei Zhu,Peter Arensburger,Patricia V. Pietrantonio,Stephen C. Barker,Renfu Shao,Evgeny M. Zdobnov,Evgeny M. Zdobnov,Frank Hauser,Cornelis J. P. Grimmelikhuijzen,Yoonseong Park,Julio Rozas,Richard Benton,Joao H. F. Pedra,Joao H. F. Pedra,David R. Nelson,Maria F. Unger,Jose M. C. Tubio,Jose M. C. Tubio,Zhijian Jake Tu,Hugh M. Robertson,Martin Shumway,Martin Shumway,Granger G. Sutton,Jennifer R. Wortman,Daniel Lawson,Stephen K. Wikel,Vishvanath Nene,Vishvanath Nene,Claire M. Fraser,Frank H. Collins,Bruce W. Birren,Karen E. Nelson,Elisabet Caler,Elisabet Caler,Catherine A. Hill +124 more
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TLDR
Insights from genome analyses into parasitic processes unique to ticks, including host ‘questing', prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival are reported.Abstract:
Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing ∼57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick-host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host 'questing', prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent.read more
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The house spider genome reveals an ancient whole-genome duplication during arachnid evolution
Evelyn E. Schwager,Evelyn E. Schwager,Prashant P. Sharma,Thomas H. Clarke,Thomas H. Clarke,Thomas H. Clarke,Daniel J. Leite,Torsten Wierschin,Matthias Pechmann,Yasuko Akiyama-Oda,Lauren A. Esposito,Jesper Bechsgaard,Trine Bilde,Alexandra D. Buffry,Hsu Chao,Huyen Dinh,Harshavardhan Doddapaneni,Shannon Dugan,Cornelius Eibner,Cassandra G. Extavour,Peter Funch,Jessica E. Garb,Luis Baudouin Gonzalez,Vanessa L. González,Sam Griffiths-Jones,Yi Han,Cheryl Y. Hayashi,Cheryl Y. Hayashi,Maarten Hilbrant,Maarten Hilbrant,Daniel S.T. Hughes,Ralf Janssen,Sandra L. Lee,Ignacio Maeso,Shwetha C. Murali,Donna M. Muzny,Rodrigo Nunes da Fonseca,Christian L. B. Paese,Jiaxin Qu,Matthew Ronshaugen,Christoph Schomburg,Anna Schoenauer,Angelika Stollewerk,Montserrat Torres-Oliva,Natascha Turetzek,Bram Vanthournout,Bram Vanthournout,John H. Werren,Carsten Wolff,Kim C. Worley,Gregor Bucher,Richard A. Gibbs,Jonathan A. Coddington,Hiroki Oda,Mario Stanke,Nadia A. Ayoub,Nikola-Michael Prpic,Jean-François Flot,Nico Posnien,Stephen Richards,Alistair P. McGregor +60 more
TL;DR: The results reveal that spiders and scorpions are likely the descendants of a polyploid ancestor that lived more than 450 MYA, and this study of the ancient WGD event in Arachnopulmonata provides a new comparative platform to explore common and divergent evolutionary outcomes ofpolyploidization events across eukaryotes.
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Beyond chemoreception: diverse tasks of soluble olfactory proteins in insects.
TL;DR: The wide versatility of both OBPs and CSPs in nature has suggested several different uses for these proteins in biotechnological applications, from biosensors for odours to scavengers for pollutants and controlled releasers of chemicals in the environment.
Journal ArticleDOI
Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases
José de la Fuente,José de la Fuente,Sandra Antunes,Sarah Bonnet,Alejandro Cabezas-Cruz,Alejandro Cabezas-Cruz,Alejandro Cabezas-Cruz,Ana Domingos,Agustín Estrada-Peña,Nicholas Johnson,Nicholas Johnson,Katherine M. Kocan,Karen L. Mansfield,Karen L. Mansfield,Ard M. Nijhof,Anna Papa,Nataliia Rudenko,Margarita Villar,Pilar Alberdi,Alessandra Torina,Nieves Ayllón,Marie Vancová,Maryna Golovchenko,Libor Grubhoffer,Libor Grubhoffer,Santo Caracappa,Anthony R. Fooks,Anthony R. Fooks,Christian Gortázar,Ryan O. M. Rego,Ryan O. M. Rego +30 more
TL;DR: This review provides a comprehensive overview of tick-pathogen molecular interactions for bacteria, viruses, and protozoa affecting human and animal health and suggests some of the similar mechanisms used by the pathogens for infection and transmission by ticks may assist in development of preventative strategies against multiple tick-borne diseases.
Journal ArticleDOI
Clonal genome evolution and rapid invasive spread of the marbled crayfish
Julian Gutekunst,Ranja Andriantsoa,Cassandra Falckenhayn,Katharina Hanna,Wolfgang Stein,Jeanne Rasamy,Frank Lyko +6 more
TL;DR: The authors sequence the genome of the marbled crayfish and show that evolution of this decapod crustacean involved genome duplication, triploidy and clonal expansion.
Journal ArticleDOI
Evolutionary changes in symbiont community structure in ticks.
Olivier Duron,Florian Binetruy,Valérie Noël,Julie Cremaschi,Karen D. McCoy,Céline Arnathau,Olivier Plantard,John A. Goolsby,Adalberto A. Pérez de León,Dieter Heylen,A. Raoul Van Oosten,Yuval Gottlieb,Gad Baneth,Alberto A. Guglielmone,Agustín Estrada-Peña,Maxwell N. Opara,Lionel Zenner,Fabrice Vavre,Christine Chevillon +18 more
TL;DR: Examination of 81 tick species shows that some Coxiella‐LE symbioses are evolutionarily stable with an ancient acquisition followed by codiversification as observed in ticks belonging to the Rhipicephalus genus, however, many other Coxiellas-LE symbionts are characterized by low evolutionary stability with frequent host shifts and extinction events.
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