J
Jenica L. Abrudan
Researcher at Children's Hospital of Philadelphia
Publications - 13
Citations - 1256
Jenica L. Abrudan is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 7, co-authored 8 publications receiving 1079 citations. Previous affiliations of Jenica L. Abrudan include University of Nevada, Las Vegas & University of Notre Dame.
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Journal ArticleDOI
Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics
Peter Arensburger,Karyn Megy,Robert M. Waterhouse,Robert M. Waterhouse,Jenica L. Abrudan,Paolo Amedeo,Beatriz García Antelo,Lyric C. Bartholomay,Shelby L. Bidwell,Elisabet Caler,Francisco Camara,Corey L. Campbell,Kathryn S. Campbell,Claudio Casola,Marta T Castro,Ishwar Chandramouliswaran,Sinéad B. Chapman,Scott Christley,Javier Costas,Eric Eisenstadt,Cédric Feschotte,Claire M. Fraser-Liggett,Roderic Guigó,Brian J. Haas,Martin Hammond,Bill S. Hansson,Janet Hemingway,Sharon R. Hill,Clint Howarth,Rickard Ignell,Ryan C. Kennedy,Chinnappa D. Kodira,Neil F. Lobo,Chunhong Mao,George F. Mayhew,Kristin Michel,Akio Mori,Nannan Liu,Horacio Naveira,Vishvanath Nene,Vishvanath Nene,Nam P. Nguyen,Matthew D. Pearson,Ellen J. Pritham,Daniela Puiu,Yumin Qi,Hilary Ranson,José M. C. Ribeiro,Hugh M Roberston,David W. Severson,Martin Shumway,Mario Stanke,Robert L. Strausberg,Cheng Sun,Granger G. Sutton,Zhijian Jake Tu,Jose M. C. Tubio,Maria F. Unger,Dana L. Vanlandingham,Albert J. Vilella,Owen White,Jared White,Charles S. Wondji,Jennifer R. Wortman,Evgeny M. Zdobnov,Evgeny M. Zdobnov,Evgeny M. Zdobnov,Bruce W. Birren,Bruce M. Christensen,Frank H. Collins,Anthony J. Cornel,George Dimopoulos,Linda Hannick,Stephen Higgs,Gregory C. Lanzaro,Daniel Lawson,Norman H. Lee,Marc A. T. Muskavitch,Marc A. T. Muskavitch,Marc A. T. Muskavitch,Alexander S. Raikhel,Peter W. Atkinson +81 more
TL;DR: The genomic sequence of C. quinquefasciatus is described, which reveals distinctions related to vector capacities and habitat preferences, and confirmed that inoculation with unfamiliar bacteria prompted strong immune responses in Culex.
Journal ArticleDOI
Genomic insights into the Ixodes scapularis tick vector of Lyme disease
Monika Gulia-Nuss,Monika Gulia-Nuss,Andrew B. Nuss,Andrew B. Nuss,Jason M. Meyer,Jason M. Meyer,Daniel E. Sonenshine,R. Michael Roe,Robert M. Waterhouse,David B. Sattelle,José de la Fuente,José de la Fuente,José M. C. Ribeiro,Karyn Megy,Karyn Megy,Jyothi Thimmapuram,Jason R. Miller,Brian P. Walenz,Brian P. Walenz,Sergey Koren,Sergey Koren,Jessica B. Hostetler,Jessica B. Hostetler,Mathangi Thiagarajan,Mathangi Thiagarajan,Vinita Joardar,Vinita Joardar,Linda Hannick,Linda Hannick,Shelby L. Bidwell,Shelby L. Bidwell,Martin Hammond,Sarah Young,Qiandong Zeng,Jenica L. Abrudan,Jenica L. Abrudan,Francisca C. Almeida,Nieves Ayllón,Ketaki Bhide,Brooke W. Bissinger,Elena Bonzón-Kulichenko,Steven D. Buckingham,Daniel R. Caffrey,Melissa J. Caimano,Vincent Croset,Vincent Croset,Timothy P. Driscoll,Timothy P. Driscoll,Don Gilbert,Joseph J. Gillespie,Joseph J. Gillespie,Gloria I. Giraldo-Calderón,Gloria I. Giraldo-Calderón,Jeffrey M. Grabowski,Jeffrey M. Grabowski,David Jiang,Sayed M.S. Khalil,Donghun Kim,Donghun Kim,Katherine M. Kocan,Juraj Koči,Juraj Koči,Richard J. Kuhn,Timothy J. Kurtti,Kristin Lees,Kristin Lees,Emma G. Lang,Ryan C. Kennedy,Hyeogsun Kwon,Hyeogsun Kwon,Rushika Perera,Rushika Perera,Yumin Qi,Justin D. Radolf,Joyce M. Sakamoto,Alejandro Sánchez-Gracia,Maiara S. Severo,Maiara S. Severo,Neal S. Silverman,Ladislav Šimo,Ladislav Šimo,Marta Tojo,Marta Tojo,Cristian Tornador,Janice P. Van Zee,Jesús Vázquez,Filipe G. Vieira,Margarita Villar,Adam R. Wespiser,Yunlong Yang,Jiwei Zhu,Peter Arensburger,Patricia V. Pietrantonio,Stephen C. Barker,Renfu Shao,Evgeny M. Zdobnov,Evgeny M. Zdobnov,Frank Hauser,Cornelis J. P. Grimmelikhuijzen,Yoonseong Park,Julio Rozas,Richard Benton,Joao H. F. Pedra,Joao H. F. Pedra,David R. Nelson,Maria F. Unger,Jose M. C. Tubio,Jose M. C. Tubio,Zhijian Jake Tu,Hugh M. Robertson,Martin Shumway,Martin Shumway,Granger G. Sutton,Jennifer R. Wortman,Daniel Lawson,Stephen K. Wikel,Vishvanath Nene,Vishvanath Nene,Claire M. Fraser,Frank H. Collins,Bruce W. Birren,Karen E. Nelson,Elisabet Caler,Elisabet Caler,Catherine A. Hill +124 more
TL;DR: Insights from genome analyses into parasitic processes unique to ticks, including host ‘questing', prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival are reported.
Journal ArticleDOI
Actionable exomic incidental findings in 6503 participants: challenges of variant classification
Laura M. Amendola,Michael O. Dorschner,Peggy D. Robertson,Joseph Salama,Ragan Hart,Brian H. Shirts,Mitzi L. Murray,Mari Tokita,Carlos J. Gallego,Daniel Seung Kim,James T. Bennett,David R. Crosslin,Jane E. Ranchalis,Kelly L. Jones,Elisabeth A. Rosenthal,Ella R. Jarvik,Andy Itsara,Emily H. Turner,Daniel S. Herman,Jennifer Schleit,Amber A. Burt,Seema M. Jamal,Jenica L. Abrudan,Andrew D. Johnson,Laura K. Conlin,Laura K. Conlin,Matthew C. Dulik,Avni Santani,Avni Santani,Danielle R. Metterville,Melissa A. Kelly,Ann Katherine M. Foreman,Kristy Lee,Kent D. Taylor,Xiuqing Guo,Kristy Crooks,Lesli A. Kiedrowski,Leslie J. Raffel,Ora Gordon,Kalotina Machini,Kalotina Machini,Kalotina Machini,Robert J. Desnick,Leslie G. Biesecker,Steven A. Lubitz,Surabhi Mulchandani,Greg M. Cooper,Steven Joffe,C. Sue Richards,Yaoping Yang,Jerome I. Rotter,Stephen S. Rich,Christopher J. O'Donnell,Jonathan S. Berg,Nancy B. Spinner,Nancy B. Spinner,James P. Evans,Stephanie M. Fullerton,Kathleen A. Leppig,Robin L. Bennett,Thomas D. Bird,Thomas D. Bird,Virginia P. Sybert,Virginia P. Sybert,William M. Grady,William M. Grady,Holly K. Tabor,Holly K. Tabor,Jerry H. Kim,Michael J. Bamshad,Benjamin S. Wilfond,Benjamin S. Wilfond,Arno G. Motulsky,C. Ronald Scott,Colin C. Pritchard,Tom Walsh,Wylie Burke,Wendy H. Raskind,Peter H. Byers,Fuki M. Hisama,Heidi L. Rehm,Heidi L. Rehm,Deborah A. Nickerson,Gail P. Jarvik +83 more
TL;DR: A refined estimate of the burden of adult onset, medically actionable incidental findings expected from exome sequencing is provided, challenges in variant classification are highlighted, and the need for a better curated variant interpretation knowledge base is demonstrated.
Journal ArticleDOI
The Characterization of the Phlebotomus papatasi Transcriptome
Jenica L. Abrudan,Marcelo Ramalho-Ortigao,Shawn T. O’Neil,Gwen Stayback,Mariha Wadsworth,Megan A. Bernard,Doug A Shoue,Scott J. Emrich,Phillip G. Lawyer,Shaden Kamhawi,Edgar Rowton,Michael J. Lehane,Paul A. Bates,Jesus G. Valenzeula,Chad Tomlinson,Elizabeth L. Appelbaum,Deborah Moeller,Brenda Thiesing,Rod J. Dillon,Sandra W. Clifton,Neil F. Lobo,Richard K. Wilson,Frank H. Collins,Mary Ann McDowell +23 more
TL;DR: The first global transcriptome analysis of the Old World vector of cutaneous leishmaniasis, Phlebotomus papatasi (Scopoli) is presented and this transcriptome will greatly improve the available genomic resources for P. papatasi and will provide essential information for annotation of the full genome.
Journal ArticleDOI
Utility and limitations of exome sequencing as a genetic diagnostic tool for children with hearing loss.
Sarah E Sheppard,Sarah E Sheppard,Sawona Biswas,Sawona Biswas,Mindy H. Li,Vijayakumar Jayaraman,Ian Slack,Edward J. Romasko,Edward J. Romasko,Ariella Sasson,Joshua Brunton,Ramakrishnan Rajagopalan,Ramakrishnan Rajagopalan,Mahdi Sarmady,Mahdi Sarmady,Jenica L. Abrudan,Jenica L. Abrudan,Sowmya Jairam,Sowmya Jairam,Sowmya Jairam,Elizabeth T. DeChene,Xiahoan Ying,Jiwon Choi,Alisha Wilkens,Sarah E. Raible,Maria I. Scarano,Avni Santani,Avni Santani,Jeffrey W. Pennington,Minjie Luo,Minjie Luo,Laura K. Conlin,Laura K. Conlin,Batsal Devkota,Matthew C. Dulik,Matthew C. Dulik,Nancy B. Spinner,Nancy B. Spinner,Ian D. Krantz,Ian D. Krantz +39 more
TL;DR: Exome sequencing has an improved yield compared with clinical testing and may capture diagnoses not initially considered due to subtle clinical phenotypes and technical challenges were identified, including inadequate capture and coverage of HL genes.