M
Manikandan Narayanan
Researcher at National Institutes of Health
Publications - 30
Citations - 2486
Manikandan Narayanan is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 14, co-authored 23 publications receiving 2054 citations. Previous affiliations of Manikandan Narayanan include Indian Institute of Technology Madras & Bosch.
Papers
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Journal ArticleDOI
Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
Bin Zhang,Chris Gaiteri,Liviu-Gabriel Bodea,Zhi Wang,Joshua J McElwee,Alexei A. Podtelezhnikov,Chunsheng Zhang,Tao Xie,Linh M. Tran,Radu Dobrin,Eugene M. Fluder,Bruce E. Clurman,Stacey Melquist,Manikandan Narayanan,Christine Suver,Hardik Shah,Milind Mahajan,Tammy Gillis,Jayalakshmi S. Mysore,Marcy E. MacDonald,John Lamb,David A. Bennett,Cliona Molony,David J. Stone,Vilmundur Gudnason,Amanda J. Myers,Eric E. Schadt,Harald Neumann,Jun Zhu,Valur Emilsson +29 more
TL;DR: The causal network structure is a useful predictor of response to gene perturbations and presents a framework to test models of disease mechanisms underlying LOAD.
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Global analyses of human immune variation reveal baseline predictors of postvaccination responses.
John S. Tsang,Pamela L. Schwartzberg,Yuri Kotliarov,Angelique Biancotto,Zhi Xie,Ronald N. Germain,Ena Wang,Matthew J. Olnes,Manikandan Narayanan,Hana Golding,Susan Moir,Howard B. Dickler,Shira Perl,Foo Cheung +13 more
TL;DR: Independent of age and pre-existing antibody titers, accurate models could be constructed using pre-perturbation cell populations alone, which were validated using independent baseline time points.
Journal ArticleDOI
Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases
Manikandan Narayanan,Jimmy L. Huynh,Kai Wang,Xia Yang,Seungyeul Yoo,Joshua McElwee,Bin Zhang,Chunsheng Zhang,John Lamb,Tao Xie,Christine Suver,Cliona Molony,Stacey Melquist,Andrew D. Johnson,Guoping Fan,David J. Stone,Eric E. Schadt,Patrizia Casaccia,Valur Emilsson,Jun Zhu +19 more
TL;DR: Using expression profiles from postmortem prefrontal cortex samples of 624 dementia patients and non‐demented controls, this work identified a 242‐gene subnetwork enriched for independent AD/HD signatures, which revealed a surprising dichotomy of gained/lost correlations among two inter‐connected processes, chromatin organization and neural differentiation.
Journal ArticleDOI
Lineage relationship of CD8 + T cell subsets is revealed by progressive changes in the epigenetic landscape
Joseph G. Crompton,Manikandan Narayanan,Suresh Cuddapah,Rahul Roychoudhuri,Yun Ji,Wenjing Yang,Shashank J. Patel,Madhusudhanan Sukumar,Douglas C. Palmer,Weiqun Peng,Ena Wang,Francesco M. Marincola,Francesco M. Marincola,Christopher A. Klebanoff,Keji Zhao,John S. Tsang,Luca Gattinoni,Nicholas P. Restifo +17 more
TL;DR: The results suggest that CD8+ lymphocytes undergo chromatin remodeling in a progressive fashion, and have major implications for the understanding of peripheral T-cell ontogeny and the formation of immunological memory.
Posted Content
Comparing Protein Interaction Networks via a Graph Match-and-Split Algorithm
TL;DR: A method that compares the protein interaction networks of two species to detect functionally similar (conserved) protein modules between them, based on an algorithm developed to identify matching subgraphs between two graphs that performs competitively with and sometimes better than two previous network comparison methods.