M
Manju Swaroop
Researcher at National Institutes of Health
Publications - 46
Citations - 17398
Manju Swaroop is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Induced pluripotent stem cell & Gene. The author has an hindex of 28, co-authored 43 publications receiving 16652 citations. Previous affiliations of Manju Swaroop include University of Michigan & Yale University.
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Journal ArticleDOI
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
Marcy E. MacDonald,Christine Ambrose,Mabel P. Duyao,Richard H. Myers,Carol Lin,Lakshmi Srinidhi,Glenn Barnes,Sherryl A.M. Taylor,Marianne James,Nicolet Groot,Heather MacFarlane,Barbara Jenkins,Mary Anne Anderson,Nancy S. Wexler,James F. Gusella,Gillian P. Bates,Sarah Baxendale,Holger Hummerich,Susan F. Kirby,Mike North,S. Youngman,Richard Mott,Günther Zehetner,Zdenek Sedlacek,Annemarie Poustka,Anna-Maria Frischauf,Hans Lehrach,Alan Buckler,Deanna M. Church,Lynn Doucette-Stamm,Michael Conlon O'Donovan,Laura Riba-Ramirez,Manish A. Shah,Vincent P. Stanton,Scott A. Strobel,Karen M. Draths,Jennifer L. Wales,Peter B. Dervan,David E. Housman,Michael R. Altherr,Rita Shiang,Leslie M. Thompson,Thomas J. Fielder,John J. Wasmuth,Danilo A. Tagle,John Valdes,Lawrence W. Elmer,Marc W. Allard,Lucio H. Castilla,Manju Swaroop,Kris Blanchard,Francis S. Collins,Russell G. Snell,Tracey Holloway,Kathleen Gillespie,Nicole A. Datson,Duncan Shaw,Peter S. Harper +57 more
TL;DR: In this article, the authors used haplotype analysis of linkage disequilibrium to spotlight a small segment of 4p16.3 as the likely location of the defect, which is expanded and unstable on HD chromosomes.
Journal Article
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.
Manish A. Shah,Nicole A. Datson,Lakshmi Srinidhi,Vincent P. Stanton,Marcy E. MacDonald,Marc W. Allard,S. Youngman,Anna-Maria Frischauf,Richard Mott,KM Draths,Günther Zehetner,C. O’Donovan,Thomas J. Fielder,Bruce G. Jenkins,Manju Swaroop,Sherryl A.M. Taylor,Lynn Doucette-Stamm,Heather MacFarlane,Scott A. Strobel,H. E. McFarlane,Alan Buckler,Nicolet Groot,Holger Hummerich,Deanna M. Church,M. A. Anderson,Marianne James,Glenn Barnes,M. Christine,Francis S. Collins,Mabel P. Duyao,Peter B. Dervan,Gillian P. Bates,T Holloway,Peter S. Harper,TW Mcdonald,M North,K Blanchard,John J. Wasmuth,D. Shaw,Hans Lehrach,Danilo A. Tagle,Annemarie Poustka,David E. Housman,T. Huntington,Zdenek Sedlacek,Laura Riba,Susan F. Kirby,Carol Lin,Richard H. Myers,Leslie M. Thompson,Russell G. Snell,Michael Conlon O'Donovan,K Gillespie,Rita Shiang,Nancy S. Wexler,Christine Ambrose,J. F. Gusella,Sarah Baxendale,N. Groat,John Valdes +59 more
TL;DR: The Huntington's disease mutation involves an unstable DNA segment, similar to those described in fragile X syndrome, spino-bulbar muscular atrophy, and myotonic dystrophy, acting in the context of a novel 4p16.3 gene to produce a dominant phenotype.
Journal ArticleDOI
Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues.
Theresa V. Strong,Danilo A. Tagle,John Valdes,Lawrence W. Elmer,Karina Boehm,Manju Swaroop,Kevin W. Kaatz,Francis S. Collins,Roger L. Albin +8 more
TL;DR: The regional specificity of neuropathology in HD, which is most prominent in the basal ganglia, thus cannot be accounted for by the pattern of expression of HD.
Journal ArticleDOI
cDNA cloning of the type 1 neurofibromatosis gene: Complete sequence of the NF1 gene product
Douglas A. Marchuk,Ann M. Saulino,Roxanne Tavakkol,Manju Swaroop,Margaret R. Wallace,Lone B. Andersen,Anna L. Mitchell,David H. Gutmann,Mark S. Boguski,Francis S. Collins +9 more
TL;DR: An extensive cDNA walk resulting in the cloning of the complete coding region of the NF1 transcript is presented, which reveals an open reading frame of 2818 amino acids, although alternatively spliced products may code for different protein isoforms.
Journal ArticleDOI
Transcriptional Activation of the Human Glutathione Peroxidase Promoter by p53
TL;DR: This is the first report demonstrating that GPX is a novel p53 target gene, and the finding links the p53 tumor suppressor to an antioxidant enzyme and will facilitate study of the p 53 signaling pathway and antioxidant enzyme regulation.