T
Timothy M. Jacobs
Researcher at University of North Carolina at Chapel Hill
Publications - 24
Citations - 1086
Timothy M. Jacobs is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Agglutination (biology) & Protein design. The author has an hindex of 10, co-authored 23 publications receiving 555 citations. Previous affiliations of Timothy M. Jacobs include Durham University & State University of New York System.
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Journal ArticleDOI
Macromolecular modeling and design in Rosetta: recent methods and frameworks
Julia Koehler Leman,Brian D. Weitzner,Brian D. Weitzner,Steven M. Lewis,Steven M. Lewis,Jared Adolf-Bryfogle,Nawsad Alam,Rebecca F. Alford,Melanie L. Aprahamian,David Baker,Kyle A. Barlow,Patrick Barth,Patrick Barth,Benjamin Basanta,Brian J. Bender,Kristin Blacklock,Jaume Bonet,Jaume Bonet,Scott E. Boyken,Phil Bradley,Christopher Bystroff,Patrick Conway,Seth Cooper,Bruno E. Correia,Bruno E. Correia,Brian Coventry,Rhiju Das,René M. de Jong,Frank DiMaio,Lorna Dsilva,Roland L. Dunbrack,Alex Ford,Brandon Frenz,Darwin Y. Fu,Caleb Geniesse,Lukasz Goldschmidt,Ragul Gowthaman,Jeffrey J. Gray,Dominik Gront,Sharon L. Guffy,Scott Horowitz,Po-Ssu Huang,Thomas Huber,Timothy M. Jacobs,Jeliazko R. Jeliazkov,David K. Johnson,Kalli Kappel,John Karanicolas,Hamed Khakzad,Hamed Khakzad,Karen R. Khar,Sagar D. Khare,Firas Khatib,Alisa Khramushin,Indigo Chris King,Robert Kleffner,Brian Koepnick,Tanja Kortemme,Georg Kuenze,Brian Kuhlman,Daisuke Kuroda,Jason W. Labonte,Jason W. Labonte,Jason K. Lai,Gideon Lapidoth,Andrew Leaver-Fay,Steffen Lindert,Thomas W. Linsky,Nir London,Joseph H. Lubin,Sergey Lyskov,Jack Maguire,Lars Malmström,Lars Malmström,Lars Malmström,Enrique Marcos,Orly Marcu,Nicholas A. Marze,Jens Meiler,Rocco Moretti,Vikram Khipple Mulligan,Santrupti Nerli,Christoffer Norn,Shane O’Conchúir,Noah Ollikainen,Sergey Ovchinnikov,Michael S. Pacella,Xingjie Pan,Hahnbeom Park,Ryan E. Pavlovicz,Manasi A. Pethe,Brian G. Pierce,Kala Bharath Pilla,Barak Raveh,P. Douglas Renfrew,Shourya S. Roy Burman,Aliza B. Rubenstein,Marion F. Sauer,Andreas Scheck,Andreas Scheck,William R. Schief,Ora Schueler-Furman,Yuval Sedan,Alexander M. Sevy,Nikolaos G. Sgourakis,Lei Shi,Justin B. Siegel,Daniel-Adriano Silva,Shannon Smith,Yifan Song,Amelie Stein,Maria Szegedy,Frank D. Teets,Summer B. Thyme,Ray Yu-Ruei Wang,Andrew M. Watkins,Lior Zimmerman,Richard Bonneau +117 more
TL;DR: This Perspective reviews tools developed over the past five years in the Rosetta software, including over 80 methods, and discusses improvements to the score function, user interfaces and usability.
Journal ArticleDOI
Analysis of Pre-existing IgG and IgM Antibodies against Polyethylene Glycol (PEG) in the General Population
Qi Yang,Timothy M. Jacobs,Justin D. McCallen,Dominic T. Moore,Justin T. Huckaby,Jasmine Edelstein,Samuel K. Lai +6 more
TL;DR: The widespread prevalence of pre-existing anti-PEG Ab, coupled with high Ab levels in a subset of the population, underscores the potential importance of screening patients for anti- PEG Ab levels prior to administration of therapeutics containing PEG.
Journal ArticleDOI
Design of structurally distinct proteins using strategies inspired by evolution.
Timothy M. Jacobs,Benfeard Williams,Tishan Williams,X. Xu,X. Xu,Alexander Eletsky,Alexander Eletsky,J. F. Federizon,Thomas Szyperski,Brian Kuhlman +9 more
TL;DR: This method provides a new strategy to rapidly create large numbers of diverse and designable protein scaffolds, which allows rapid design of a diverse set of structures that will facilitate functional design.
Journal ArticleDOI
Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate
Kathleen M. Mulvaney,Jacob Peter Matson,Priscila F. Siesser,Tigist Y. Tamir,Dennis Goldfarb,Timothy M. Jacobs,Erica W. Cloer,Joseph S. Harrison,Cyrus Vaziri,Jeanette Gowen Cook,Michael B. Major +10 more
TL;DR: The targeted investigation of KEAP1-interacting proteins revealed MCM3, an essential subunit of the replicative DNA helicase, as a new substrate of the KE AP1-CUL3-RBX1 E3 ligase, and it is determined thatKEAP1 does not regulate total MCM 3 protein stability or subcellular localization, and these data establish new functions for KEAP 1 within the nucleus.
Journal ArticleDOI
SwiftLib: rapid degenerate-codon-library optimization through dynamic programming.
TL;DR: A dynamic programming solution to the task of finding the best DCs while keeping the size of the library beneath some given limit, improving on the existing integer-linear programming formulation.