E
Enrique Marcos
Researcher at University of Washington
Publications - 17
Citations - 1499
Enrique Marcos is an academic researcher from University of Washington. The author has contributed to research in topics: Protein design & Enzyme structure. The author has an hindex of 14, co-authored 17 publications receiving 898 citations. Previous affiliations of Enrique Marcos include Spanish National Research Council & Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
Macromolecular modeling and design in Rosetta: recent methods and frameworks
Julia Koehler Leman,Brian D. Weitzner,Brian D. Weitzner,Steven M. Lewis,Steven M. Lewis,Jared Adolf-Bryfogle,Nawsad Alam,Rebecca F. Alford,Melanie L. Aprahamian,David Baker,Kyle A. Barlow,Patrick Barth,Patrick Barth,Benjamin Basanta,Brian J. Bender,Kristin Blacklock,Jaume Bonet,Jaume Bonet,Scott E. Boyken,Phil Bradley,Christopher Bystroff,Patrick Conway,Seth Cooper,Bruno E. Correia,Bruno E. Correia,Brian Coventry,Rhiju Das,René M. de Jong,Frank DiMaio,Lorna Dsilva,Roland L. Dunbrack,Alex Ford,Brandon Frenz,Darwin Y. Fu,Caleb Geniesse,Lukasz Goldschmidt,Ragul Gowthaman,Jeffrey J. Gray,Dominik Gront,Sharon L. Guffy,Scott Horowitz,Po-Ssu Huang,Thomas Huber,Timothy M. Jacobs,Jeliazko R. Jeliazkov,David K. Johnson,Kalli Kappel,John Karanicolas,Hamed Khakzad,Hamed Khakzad,Karen R. Khar,Sagar D. Khare,Firas Khatib,Alisa Khramushin,Indigo Chris King,Robert Kleffner,Brian Koepnick,Tanja Kortemme,Georg Kuenze,Brian Kuhlman,Daisuke Kuroda,Jason W. Labonte,Jason W. Labonte,Jason K. Lai,Gideon Lapidoth,Andrew Leaver-Fay,Steffen Lindert,Thomas W. Linsky,Nir London,Joseph H. Lubin,Sergey Lyskov,Jack Maguire,Lars Malmström,Lars Malmström,Lars Malmström,Enrique Marcos,Orly Marcu,Nicholas A. Marze,Jens Meiler,Rocco Moretti,Vikram Khipple Mulligan,Santrupti Nerli,Christoffer Norn,Shane O’Conchúir,Noah Ollikainen,Sergey Ovchinnikov,Michael S. Pacella,Xingjie Pan,Hahnbeom Park,Ryan E. Pavlovicz,Manasi A. Pethe,Brian G. Pierce,Kala Bharath Pilla,Barak Raveh,P. Douglas Renfrew,Shourya S. Roy Burman,Aliza B. Rubenstein,Marion F. Sauer,Andreas Scheck,Andreas Scheck,William R. Schief,Ora Schueler-Furman,Yuval Sedan,Alexander M. Sevy,Nikolaos G. Sgourakis,Lei Shi,Justin B. Siegel,Daniel-Adriano Silva,Shannon Smith,Yifan Song,Amelie Stein,Maria Szegedy,Frank D. Teets,Summer B. Thyme,Ray Yu-Ruei Wang,Andrew M. Watkins,Lior Zimmerman,Richard Bonneau +117 more
TL;DR: This Perspective reviews tools developed over the past five years in the Rosetta software, including over 80 methods, and discusses improvements to the score function, user interfaces and usability.
Journal ArticleDOI
De novo design of potent and selective mimics of IL-2 and IL-15
Daniel-Adriano Silva,Shawn Yu,Umut Ulge,Jamie B. Spangler,Jamie B. Spangler,Kevin Jude,Carlos Labão-Almeida,Lestat R. Ali,Alfredo Quijano-Rubio,Mikel Ruterbusch,Isabel Leung,Tamara Biary,Stephanie J. Crowley,Enrique Marcos,Carl Walkey,Brian D. Weitzner,Fátima Pardo-Avila,Javier Castellanos,Lauren Carter,Lance Stewart,Stanley R. Riddell,Marion Pepper,Gonçalo J. L. Bernardes,Gonçalo J. L. Bernardes,Michael Dougan,K. Christopher Garcia,K. Christopher Garcia,David Baker,David Baker +28 more
TL;DR: A hyper-stable de novo protein mimic of interleukin-2 computationally designed to not interact with a regulatory T-cell specific receptor subunit has improved therapeutic activity in mouse models of melanoma and colon cancer.
Journal ArticleDOI
De novo design of a fluorescence-activating β-barrel
Jiayi Dou,Anastassia A. Vorobieva,William Sheffler,Lindsey Doyle,Hahnbeom Park,Matthew J. Bick,Binchen Mao,Glenna Wink Foight,Min Yen Lee,Lauren A. Gagnon,Lauren Carter,Banumathi Sankaran,Sergey Ovchinnikov,Sergey Ovchinnikov,Enrique Marcos,Po-Ssu Huang,Po-Ssu Huang,Joshua C. Vaughan,Barry L. Stoddard,David Baker +19 more
TL;DR: This de novo design of small-molecule binding activity, using backbones custom-built to bind the ligand, should enable the design of increasingly sophisticated ligand-binding proteins, sensors and catalysts that are not limited by the backbone geometries available in known protein structures.
Journal ArticleDOI
Principles for designing proteins with cavities formed by curved β sheets
Enrique Marcos,Benjamin Basanta,Tamuka M. Chidyausiku,Yuefeng Tang,Yuefeng Tang,Gustav Oberdorfer,Gustav Oberdorfer,Gaohua Liu,Gaohua Liu,G. V. T. Swapna,G. V. T. Swapna,Rongjin Guan,Rongjin Guan,Daniel-Adriano Silva,Jiayi Dou,Jose Henrique Pereira,Jose Henrique Pereira,Rong Xiao,Rong Xiao,Banumathi Sankaran,Peter H. Zwart,Gaetano T. Montelione,Gaetano T. Montelione,David Baker +23 more
TL;DR: The principles emerging from this analysis were used to design, de novo, a series of proteins with curved β sheets topped with α helices, showing that β-sheet curvature can be controlled with atomic-level accuracy.
ComponentDOI
De novo design of a non-local beta-sheet protein with high stability and accuracy
Enrique Marcos,Tamuka M. Chidyausiku,Andrew C. McShan,Thomas Evangelidis,Santrupti Nerli,Lauren Carter,Lucas G. Nivón,Audrey Davis,Audrey Davis,Gustav Oberdorfer,Gustav Oberdorfer,Konstantinos Tripsianes,Nikolaos G. Sgourakis,David Baker +13 more
TL;DR: Baker et al. as discussed by the authors studied the structural relationships between loop geometry, side chain directionality and β-strand length that arise from hydrogen bonding and packing constraints on regular β-sheet structures.