S
Scott Horowitz
Researcher at University of Denver
Publications - 45
Citations - 1970
Scott Horowitz is an academic researcher from University of Denver. The author has contributed to research in topics: Chaperone (protein) & Protein folding. The author has an hindex of 21, co-authored 42 publications receiving 1410 citations. Previous affiliations of Scott Horowitz include University of Michigan & Howard Hughes Medical Institute.
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Journal ArticleDOI
Macromolecular modeling and design in Rosetta: recent methods and frameworks
Julia Koehler Leman,Brian D. Weitzner,Brian D. Weitzner,Steven M. Lewis,Steven M. Lewis,Jared Adolf-Bryfogle,Nawsad Alam,Rebecca F. Alford,Melanie L. Aprahamian,David Baker,Kyle A. Barlow,Patrick Barth,Patrick Barth,Benjamin Basanta,Brian J. Bender,Kristin Blacklock,Jaume Bonet,Jaume Bonet,Scott E. Boyken,Phil Bradley,Christopher Bystroff,Patrick Conway,Seth Cooper,Bruno E. Correia,Bruno E. Correia,Brian Coventry,Rhiju Das,René M. de Jong,Frank DiMaio,Lorna Dsilva,Roland L. Dunbrack,Alex Ford,Brandon Frenz,Darwin Y. Fu,Caleb Geniesse,Lukasz Goldschmidt,Ragul Gowthaman,Jeffrey J. Gray,Dominik Gront,Sharon L. Guffy,Scott Horowitz,Po-Ssu Huang,Thomas Huber,Timothy M. Jacobs,Jeliazko R. Jeliazkov,David K. Johnson,Kalli Kappel,John Karanicolas,Hamed Khakzad,Hamed Khakzad,Karen R. Khar,Sagar D. Khare,Firas Khatib,Alisa Khramushin,Indigo Chris King,Robert Kleffner,Brian Koepnick,Tanja Kortemme,Georg Kuenze,Brian Kuhlman,Daisuke Kuroda,Jason W. Labonte,Jason W. Labonte,Jason K. Lai,Gideon Lapidoth,Andrew Leaver-Fay,Steffen Lindert,Thomas W. Linsky,Nir London,Joseph H. Lubin,Sergey Lyskov,Jack Maguire,Lars Malmström,Lars Malmström,Lars Malmström,Enrique Marcos,Orly Marcu,Nicholas A. Marze,Jens Meiler,Rocco Moretti,Vikram Khipple Mulligan,Santrupti Nerli,Christoffer Norn,Shane O’Conchúir,Noah Ollikainen,Sergey Ovchinnikov,Michael S. Pacella,Xingjie Pan,Hahnbeom Park,Ryan E. Pavlovicz,Manasi A. Pethe,Brian G. Pierce,Kala Bharath Pilla,Barak Raveh,P. Douglas Renfrew,Shourya S. Roy Burman,Aliza B. Rubenstein,Marion F. Sauer,Andreas Scheck,Andreas Scheck,William R. Schief,Ora Schueler-Furman,Yuval Sedan,Alexander M. Sevy,Nikolaos G. Sgourakis,Lei Shi,Justin B. Siegel,Daniel-Adriano Silva,Shannon Smith,Yifan Song,Amelie Stein,Maria Szegedy,Frank D. Teets,Summer B. Thyme,Ray Yu-Ruei Wang,Andrew M. Watkins,Lior Zimmerman,Richard Bonneau +117 more
TL;DR: This Perspective reviews tools developed over the past five years in the Rosetta software, including over 80 methods, and discusses improvements to the score function, user interfaces and usability.
Journal ArticleDOI
Carbon-Oxygen Hydrogen Bonding in Biological Structure and Function
TL;DR: The impact of CH···O bonds on protein and nucleic acid structure, molecular recognition, and enzyme catalysis is examined and overarching themes and unresolved questions regarding unconventional interactions in biomolecular structure are explored.
Journal ArticleDOI
Increased arginase activity and endothelial dysfunction in human inflammatory bowel disease.
Scott Horowitz,David G. Binion,Victoria M. Nelson,Yasmin Kanaa,Pooria Javadi,Zelmira Lazarova,Christopher Andrekopoulos,Balaraman Kalyanaraman,Mary F. Otterson,Parvaneh Rafiee +9 more
TL;DR: Loss of .NO production in IBD microvessels is linked to enhanced levels of AR in intestinal endothelial cells exposed to chronic inflammation in vivo, and its contribution to decreased .NOProduction was characterized.
Journal ArticleDOI
Conservation and functional importance of carbon-oxygen hydrogen bonding in AdoMet-dependent methyltransferases
Scott Horowitz,Lynnette M.A. Dirk,Joseph D. Yesselman,Jennifer S Nimtz,Upendra Adhikari,Ryan A. Mehl,Steve Scheiner,Robert L. Houtz,Hashim M. Al-Hashimi,Raymond C. Trievel +9 more
TL;DR: Experimental findings imply that methyl CH···O hydrogen bonding represents a convergent evolutionary feature of AdoMet-dependent methyltransferases, mediating a universal mechanism for methyl transfer.
Journal ArticleDOI
Sulfur-Oxygen Chalcogen Bonding Mediates AdoMet Recognition in the Lysine Methyltransferase SET7/9.
Robert J. Fick,Grace M. Kroner,Binod Nepal,Roberta Magnani,Scott Horowitz,Robert L. Houtz,Steve Scheiner,Raymond C. Trievel +7 more
TL;DR: It is demonstrated that S···O chalcogen bonds contribute to AdoMet recognition and can enable methyltransferases to distinguish between substrate and product.