S
Sunil J. Patel
Researcher at Medical University of South Carolina
Publications - 124
Citations - 3886
Sunil J. Patel is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 28, co-authored 90 publications receiving 3355 citations.
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Journal ArticleDOI
Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency
Eric Bouffet,Valérie Larouche,Brittany Campbell,Daniele Merico,Richard de Borja,Melyssa Aronson,Carol Durno,Joerg Krueger,Vanja Cabric,Vijay Ramaswamy,Nataliya Zhukova,Gary Mason,Roula Farah,Samina Afzal,Michal Yalon,Gideon Rechavi,Vanan Magimairajan,Michael Walsh,Shlomi Constantini,Rina Dvir,Ronit Elhasid,Alyssa Reddy,Michael Osborn,Michael J. Sullivan,Jordan R. Hansford,Andrew Dodgshun,Nancy Klauber-DeMore,Lindsay L. Peterson,Sunil J. Patel,Scott Lindhorst,Jeffrey Atkinson,Zane Cohen,Rachel Laframboise,Peter B. Dirks,Michael D. Taylor,David Malkin,Steffen Albrecht,Roy W. R. Dudley,Nada Jabado,Cynthia Hawkins,Adam Shlien,Uri Tabori +41 more
TL;DR: This report of initial and durable responses of recurrent GBM to immune checkpoint inhibition may have implications for GBM in general and other hypermutant cancers arising from primary (genetic predisposition) or secondary MMRD.
Journal ArticleDOI
Angiopoietin-2 Regulates Gene Expression in TIE2-Expressing Monocytes and Augments Their Inherent Proangiogenic Functions
Seth B. Coffelt,Andrea Tal,Alexander Scholz,Michele De Palma,Sunil J. Patel,Carmen Urbich,Subhra K. Biswas,Craig Murdoch,Karl H. Plate,Yvonne Reiss,Claire E. Lewis +10 more
TL;DR: It is shown that circulating human TEMs are already preprogrammed in the circulation to be more angiogenic and express higher levels of such proangiogenic genes as matrix metalloproteinase-9 (MMP-9), VEGFA, COX-2, and WNT5A than TIE2(-) monocytes.
Journal ArticleDOI
Poor drug distribution as a possible explanation for the results of the PRECISE trial.
John H. Sampson,Gary E. Archer,Christoph Pedain,Eva Wembacher-Schröder,Manfred Westphal,Sandeep Kunwar,Michael A. Vogelbaum,April Coan,James E. Herndon,Raghu Raghavan,Martin Brady,David A. Reardon,Allan H. Friedman,Henry S. Friedman,M. Inmaculada Rodríguez-Ponce,Susan M. Chang,Stephan Mittermeyer,Davi Croteau,Raj K. Puri,James M. Markert,Michael D. Prados,Thomas C. Chen,Adam N. Mamelak,Timothy F. Cloughesy,John S. Yu,Kevin O. Lillehei,Joseph M. Piepmeier,Edward Pan,Frank D. Vrionis,H. Lee Moffitt,Jeffrey J. Olson,James P. Chandler,Nina Paleologos,Richard W. Byrne,Maciej S. Lesniak,Jon D. Weingart,Peter McL. Black,Tom Mikkelsen,Joon H. Uhm,Richard D. Bucholz,Lauren E. Abrey,Theodore H. Schwartz,Jeffrey N. Bruce,Anthony L. Asher,Stephen B. Tatter,Gene Barnett,Antonio E. Chiocca,Johnny B. Delashaw,Kevin Judy,Sunil J. Patel,Bruce Frankel,Frederick F. Lang,Pamela New,Karen Fink,Randy L. Jensen,Mark E. Shaffrey,Lynne P. Taylor,Warren Boling,Behnam Badie,Abhijit Guha,Vivek Mehta,Mark G. Hamilton,David D. Eisenstat,Farhad Pirouzmand,David R. Macdonald,Rolando F. Del Maestro,Daryl R. Fourney,Maximilian Mehdorn,Roland Goldbrunner,Gabriele Schackert,Andreas Unterberg,Zvi Ram,Zvi R. Cohen,Zvi H. Rappaport,Jan Jacob Mooij,John G. Wolbers,Peter C. Warnke,Varnavas Papanastassiou +77 more
TL;DR: Routine use of software algorithms and alternative catheter designs and infusion parameters may improve the efficacy of drugs delivered by CED, which may be severely constrained by ineffective delivery in many patients.
Journal ArticleDOI
Drug Resistance in Glioblastoma: A Mini Review
Catherine P. Haar,Preetha Hebbar,Gerald C. Wallace,Arabinda Das,William A. Vandergrift,Joshua A. Smith,Pierre Giglio,Sunil J. Patel,Swapan K. Ray,Naren L. Banik +9 more
TL;DR: Future research and clinical trials in glioblastoma patients should pursue combination of therapies to help combat drug resistance, including a series of investigated alternative and plant-derived agents.
Journal ArticleDOI
N-Acetyl cysteine protects against injury in a rat model of focal cerebral ischemia
Bipanjeet Sekhon,Charanpal Sekhon,Mushfiquddin Khan,Sunil J. Patel,Inderjit Singh,Avtar K. Singh,Avtar K. Singh +6 more
TL;DR: The data suggest that pre-administration of N-acetyl cysteine attenuates cerebral ischemia and reperfusion injury in this brain ischemIA model, and this protective effect may be as a result of suppression of TNF-alpha and iNOS.