M
Martin Hemberg
Researcher at Wellcome Trust Sanger Institute
Publications - 125
Citations - 13581
Martin Hemberg is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Gene & Biology. The author has an hindex of 37, co-authored 102 publications receiving 10274 citations. Previous affiliations of Martin Hemberg include Boston Children's Hospital & Wellcome Trust/Cancer Research UK Gurdon Institute.
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Journal ArticleDOI
Widespread transcription at neuronal activity-regulated enhancers
Tae Kyung Kim,Martin Hemberg,Jesse M. Gray,Allen M. Costa,Daniel M. Bear,Jing Wu,David A. Harmin,Michael W. Laptewicz,Kellie Barbara-Haley,Scott Kuersten,Eirene Markenscoff-Papadimitriou,Eirene Markenscoff-Papadimitriou,Dietmar Kuhl,Haruhiko Bito,Paul F. Worley,Gabriel Kreiman,Michael E. Greenberg +16 more
TL;DR: It is revealed that a widespread mechanism of enhancer activation involves RNAPII binding and eRNA synthesis, which occurs specifically at enhancers that are actively engaged in promoting mRNA synthesis.
Journal ArticleDOI
The Human Cell Atlas
Aviv Regev,Aviv Regev,Aviv Regev,Sarah A. Teichmann,Sarah A. Teichmann,Sarah A. Teichmann,Eric S. Lander,Eric S. Lander,Eric S. Lander,Ido Amit,Christophe Benoist,Ewan Birney,Bernd Bodenmiller,Bernd Bodenmiller,Peter J. Campbell,Peter J. Campbell,Piero Carninci,Menna R. Clatworthy,Hans Clevers,Bart Deplancke,Ian Dunham,James Eberwine,Roland Eils,Roland Eils,Wolfgang Enard,Andrew Farmer,Lars Fugger,Berthold Göttgens,Nir Hacohen,Nir Hacohen,Muzlifah Haniffa,Martin Hemberg,Seung K. Kim,Paul Klenerman,Paul Klenerman,Arnold R. Kriegstein,Ed S. Lein,Sten Linnarsson,Emma Lundberg,Emma Lundberg,Joakim Lundeberg,Partha P. Majumder,John C. Marioni,John C. Marioni,John C. Marioni,Miriam Merad,Musa M. Mhlanga,Martijn C. Nawijn,Mihai G. Netea,Garry P. Nolan,Dana Pe'er,Anthony Phillipakis,Chris P. Ponting,Stephen R. Quake,Wolf Reik,Wolf Reik,Wolf Reik,Orit Rozenblatt-Rosen,Joshua R. Sanes,Rahul Satija,Ton N. Schumacher,Alex K. Shalek,Alex K. Shalek,Alex K. Shalek,Ehud Shapiro,Padmanee Sharma,Jay W. Shin,Oliver Stegle,Michael R. Stratton,Michael J. T. Stubbington,Fabian J. Theis,Matthias Uhlen,Matthias Uhlen,Alexander van Oudenaarden,Allon Wagner,Fiona M. Watt,Jonathan S. Weissman,Barbara J. Wold,Ramnik J. Xavier,Nir Yosef,Nir Yosef,Human Cell Atlas Meeting Participants +81 more
TL;DR: An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease.
Journal ArticleDOI
SC3: consensus clustering of single-cell RNA-seq data
Vladimir Yu. Kiselev,Kristina Kirschner,Michael T. Schaub,Michael T. Schaub,Tallulah S. Andrews,Andrew Yiu,Tamir Chandra,Tamir Chandra,Kedar Nath Natarajan,Kedar Nath Natarajan,Wolf Reik,Wolf Reik,Wolf Reik,Mauricio Barahona,Anthony R. Green,Martin Hemberg +15 more
TL;DR: It is demonstrated that SC3 is capable of identifying subclones from the transcriptomes of neoplastic cells collected from patients and achieves high accuracy and robustness by combining multiple clustering solutions through a consensus approach.
Journal ArticleDOI
Transcriptome-wide noise controls lineage choice in mammalian progenitor cells
Hannah H. Chang,Martin Hemberg,Martin Hemberg,Mauricio Barahona,Donald E. Ingber,Sui Huang,Sui Huang +6 more
TL;DR: Clonal heterogeneity of gene expression level is not due to independent noise in the expression of individual genes, but reflects metastable states of a slowly fluctuating transcriptome that is distinct in individual cells and may govern the reversible, stochastic priming of multipotent progenitor cells in cell fate decision.
Journal ArticleDOI
Challenges in unsupervised clustering of single-cell RNA-seq data.
TL;DR: This Review discusses the multiple algorithmic options for clustering scRNA-seq data, including various technical, biological and computational considerations.