M
Matthias Uhlen
Researcher at Royal Institute of Technology
Publications - 6
Citations - 1582
Matthias Uhlen is an academic researcher from Royal Institute of Technology. The author has contributed to research in topics: Organism & Theoretical definition. The author has an hindex of 6, co-authored 6 publications receiving 1304 citations. Previous affiliations of Matthias Uhlen include Technical University of Denmark.
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Journal ArticleDOI
The Human Cell Atlas
Aviv Regev,Aviv Regev,Aviv Regev,Sarah A. Teichmann,Sarah A. Teichmann,Sarah A. Teichmann,Eric S. Lander,Eric S. Lander,Eric S. Lander,Ido Amit,Christophe Benoist,Ewan Birney,Bernd Bodenmiller,Bernd Bodenmiller,Peter J. Campbell,Peter J. Campbell,Piero Carninci,Menna R. Clatworthy,Hans Clevers,Bart Deplancke,Ian Dunham,James Eberwine,Roland Eils,Roland Eils,Wolfgang Enard,Andrew Farmer,Lars Fugger,Berthold Göttgens,Nir Hacohen,Nir Hacohen,Muzlifah Haniffa,Martin Hemberg,Seung K. Kim,Paul Klenerman,Paul Klenerman,Arnold R. Kriegstein,Ed S. Lein,Sten Linnarsson,Emma Lundberg,Emma Lundberg,Joakim Lundeberg,Partha P. Majumder,John C. Marioni,John C. Marioni,John C. Marioni,Miriam Merad,Musa M. Mhlanga,Martijn C. Nawijn,Mihai G. Netea,Garry P. Nolan,Dana Pe'er,Anthony Phillipakis,Chris P. Ponting,Stephen R. Quake,Wolf Reik,Wolf Reik,Wolf Reik,Orit Rozenblatt-Rosen,Joshua R. Sanes,Rahul Satija,Ton N. Schumacher,Alex K. Shalek,Alex K. Shalek,Alex K. Shalek,Ehud Shapiro,Padmanee Sharma,Jay W. Shin,Oliver Stegle,Michael R. Stratton,Michael J. T. Stubbington,Fabian J. Theis,Matthias Uhlen,Matthias Uhlen,Alexander van Oudenaarden,Allon Wagner,Fiona M. Watt,Jonathan S. Weissman,Barbara J. Wold,Ramnik J. Xavier,Nir Yosef,Nir Yosef,Human Cell Atlas Meeting Participants +81 more
TL;DR: An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease.
Journal Article
What Is Your Conceptual Definition of “Cell Type” in the Context of a Mature Organism?
Hans Clevers,Susanne M. Rafelski,Michael B. Elowitz,Allon M. Klein,Jay Shendure,Cole Trapnell,Ed S. Lein,Emma Lundberg,Matthias Uhlen,Alfonso Martinez-Arias,Joshua R. Sanes,Paul Blainey,James Eberwine,Junhyong Kim,J. Christopher Love +14 more
TL;DR: The human body can be dissected into a limited number of hard-wired cellular ‘‘clouds’’ often coinciding with histologically defined tissues, and at different time points, individual cells may occupy different positions within their respective clouds.
Journal ArticleDOI
Minimum information about a protein affinity reagent (MIAPAR)
Julie Bourbeillon,Sandra Orchard,Itai Benhar,Carl A.K. Borrebaeck,Antoine de Daruvar,Antoine de Daruvar,Stefan Dübel,Ronald Frank,Frank Gibson,David E. Gloriam,David E. Gloriam,Niall J. Haslam,Tara Hiltker,Ian Humphrey-Smith,Michael Hust,David Juncker,Manfred Koegl,Zoltán Konthur,Bernhard Korn,Sylvia Krobitsch,Serge Muyldermans,Per-Åke Nygren,Sandrine Palcy,Sandrine Palcy,Bojan Polić,Henry Rodriguez,Alan Sawyer,Martin Schlapshy,Michael Snyder,Oda Stoevesandt,Michael J. Taussig,Markus F. Templin,Matthias Uhlen,Silvère M. van der Maarel,Christer Wingren,Henning Hermjakob,David James Sherman +36 more
TL;DR: This is a proposal developed within the community as an important first step in formalizing standards in reporting the production and properties of protein binding reagents, such as antibodies, developed and sold for the identification and detection of specific proteins present in biological samples.
Journal ArticleDOI
A novel flow cytometry-based method for analysis of expression levels in Escherichia coli, giving information about precipitated and soluble protein.
My Hedhammar,Maria Stenvall,Rosa Lönneborg,Olof Nord,Olle Sjölin,Hjalmar Brismar,Matthias Uhlen,Jenny Ottosson,Sophia Hober +8 more
TL;DR: The newly developed method was used to evaluate two different purification tags, His(6) and Z(basic), and their effect on the expression pattern, and a clear correlation between fluorescence and soluble target protein was shown.
Journal ArticleDOI
Use of ENCODE resources to characterize novel proteoforms and missing proteins in the human proteome.
Carol L. Nilsson,Ekaterina Mostovenko,Cheryl F. Lichti,Kelly V. Ruggles,David Fenyö,Kate R. Rosenbloom,William S. Hancock,Young Ki Paik,Gilbert S. Omenn,Joshua LaBaer,Roger A. Kroes,Matthias Uhlen,Sophia Hober,Ákos Végvári,Per E. Andrén,Erik P. Sulman,Frederick F. Lang,Manuel Fuentes,Elisabet Carlsohn,Mark R. Emmett,Joseph R. Moskal,Frode S. Berven,Thomas E. Fehniger,György Marko-Varga +23 more
TL;DR: The utility of integrated strategies that employ both translation of ENCODE data and major proteomic technology pillars to improve the identification of the "missing proteins", novel proteoforms, and PTMs are described.