M
Masamichi Takami
Researcher at Showa University
Publications - 108
Citations - 5406
Masamichi Takami is an academic researcher from Showa University. The author has contributed to research in topics: Osteoclast & RANKL. The author has an hindex of 31, co-authored 103 publications receiving 4978 citations. Previous affiliations of Masamichi Takami include Nippon Steel & Tokyo Institute of Technology.
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Journal ArticleDOI
Tumor Necrosis Factor α Stimulates Osteoclast Differentiation by a Mechanism Independent of the Odf/Rankl–Rank Interaction
Kanichiro Kobayashi,Naoyuki Takahashi,Eijiro Jimi,Nobuyuki Udagawa,Masamichi Takami,Shigeru Kotake,Nobuaki Nakagawa,Masahiko Kinosaki,Kyoji Yamaguchi,Nobuyuki Shima,Hisataka Yasuda,Tomonori Morinaga,Kanji Higashio,T. John Martin,Tatsuo Suda +14 more
TL;DR: It is demonstrated that TNF-α stimulates osteoclast differentiation in the presence of M-CSF through a mechanism independent of the ODF/RANKL–RANK system.
Journal ArticleDOI
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis.
Nacksung Kim,Yuho Kadono,Masamichi Takami,Junwon Lee,Seoung Hoon Lee,Fumihiko Okada,Jung Ha Kim,Takashi Kobayashi,Paul R. Odgren,Hiroyasu Nakano,Wen-Chen Yeh,Sun-Kyeong Lee,Joseph A. Lorenzo,Yongwon Choi +13 more
TL;DR: Surprisingly, it is shown that hematopoietic precursors from TRANCE-, RANK-, or TRAF6-null mice can become osteoclasts in vitro when they are stimulated with TNF-α in the presence of cofactors such as TGF-β.
Journal ArticleDOI
Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis
Baohong Zhao,Masamichi Takami,Atsushi Yamada,Xiaogu Wang,Takako Koga,Xiaoyu Hu,Xiaoyu Hu,Tomohiko Tamura,Keiko Ozato,Yongwon Choi,Lionel B. Ivashkiv,Lionel B. Ivashkiv,Hiroshi Takayanagi,Ryutaro Kamijo +13 more
TL;DR: It is reported that interferon regulatory factor-8 (IRF-8), a transcription factor expressed in immune cells, is a key regulatory molecule for osteoclastogenesis and suggested a model where downregulation of inhibitory factors such as IRf-8 contributes to RANKL-mediated osteoclineogenesis.
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A Novel Member of the Leukocyte Receptor Complex Regulates Osteoclast Differentiation
TL;DR: The identification and characterization of OC-associated receptor (OSCAR), a novel member of the leukocyte receptor complex (LRC)-encoded family expressed specifically in OCs are reported, suggesting that LRC-encoded genes may have evolved to regulate the physiology of cells beyond those of the immune system.
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Stimulation by toll-like receptors inhibits osteoclast differentiation.
TL;DR: This article showed that TLR stimulation of osteoclast precursors by these microbial products strongly inhibited their differentiation into multinucleated, mature osteoclasts induced by TNF-related activation-induced cytokine.