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Pearline Teo
Researcher at Dornier Flugzeugwerke
Publications - 11
Citations - 4217
Pearline Teo is an academic researcher from Dornier Flugzeugwerke. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 8, co-authored 11 publications receiving 3688 citations. Previous affiliations of Pearline Teo include Agency for Science, Technology and Research & Stanford University.
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Journal ArticleDOI
Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes
Daigo Hashimoto,Andrew Chow,Andrew Chow,Clara Noizat,Clara Noizat,Pearline Teo,Mary Beth Beasley,Marylene Leboeuf,Christian Becker,Peter See,Jeremy Price,Daniel Lucas,Melanie Greter,Melanie Greter,Arthur Mortha,Scott W. Boyer,E. Camilla Forsberg,Masato Tanaka,Nico van Rooijen,Adolfo García-Sastre,E. Richard Stanley,Florent Ginhoux,Paul S. Frenette,Miriam Merad +23 more
TL;DR: Results indicate that tissue-resident macrophages and circulating monocytes should be classified as mononuclear phagocyte lineages that are independently maintained in the steady state.
Journal ArticleDOI
IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses
Andreas Schlitzer,Naomi McGovern,Pearline Teo,Teresa Zelante,Koji Atarashi,Donovan Low,Adrian W. S. Ho,Peter See,Amanda Shin,Pavandip Singh Wasan,Guillaume Hoeffel,Benoit Malleret,Alexander F. Heiseke,Samantha Chew,Laura Jardine,Harriet A. Purvis,Catharien M. U. Hilkens,John Kit Chung Tam,Michael Poidinger,E. Richard Stanley,Anne Krug,Laurent Rénia,Baalasubramanian Sivasankar,Lai Guan Ng,Matthew Collin,Paola Ricciardi-Castagnoli,Kenya Honda,Muzlifah Haniffa,Florent Ginhoux +28 more
TL;DR: The demonstration of mouse and human DC subsets specialized in driving IL-17 responses highlights the conservation of key immune functions across species and will facilitate the translation of mouse in vivo findings to advance DC-based clinical therapies.
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Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells
Muzlifah Haniffa,Muzlifah Haniffa,Amanda Shin,Venetia Bigley,Naomi McGovern,Pearline Teo,Peter See,Pavandip Singh Wasan,Xiao-Nong Wang,Frano Malinarich,Benoit Malleret,Anis Larbi,Pearlie W.W. Tan,Helen Zhao,Michael Poidinger,Sarah Pagan,Sharon Cookson,Rachel E. Dickinson,Ian Dimmick,Ruth F. Jarrett,Laurent Rénia,John Siu-Lun Tam,Colin Song,John E. Connolly,Jerry Kok Yen Chan,Jerry Kok Yen Chan,Adam J. Gehring,Antonio Bertoletti,Matthew Collin,Florent Ginhoux +29 more
TL;DR: A CD141hi DC present in human interstitial dermis, liver, and lung that was distinct from the majority of CD1c+ and CD14+ tissue DCs and superior at cross-presenting soluble antigens was identified.
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Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages
Guillaume Hoeffel,Yilin Wang,Melanie Greter,Peter See,Pearline Teo,Benoit Malleret,Marylene Leboeuf,Donovan Low,Guillaume Oller,Francisca F. Almeida,Sharon H.Y. Choy,Marcos Augusto Grigolin Grisotto,Laurent Rénia,Simon J. Conway,E. Richard Stanley,Jerry Kok Yen Chan,Jerry Kok Yen Chan,Lai Guan Ng,Igor M. Samokhvalov,Miriam Merad,Florent Ginhoux +20 more
TL;DR: Langerhans cell precursors initially arise from yolk sac progenitors, but are later superseded by fetal liver monocytes.
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Host NKT cells can prevent graft-versus-host disease and permit graft antitumor activity after bone marrow transplantation
TL;DR: After TLI/ATS host conditioning and allogeneic bone marrow transplantation, host NKT cells can separate the proinflammatory and tumor cytolytic functions of donor T cells.