Matthew S. Miller

TL;DR: The immunological principles that need to be taken into consideration in the development of COVID-19 vaccine strategies are discussed and their strengths and potential shortfalls are examined, and inferences about their chances of success are made.

TL;DR: This study shows that annual influenza vaccines induce antibody responses that are largely directed against the highly variable HA head region, and provides a potential vaccination strategy where heterologous influenza immunization could be used for increasing the levels of broadly neutralizing antibodies and for priming the human population to respond quickly to emerging pandemic influenza threats.

TL;DR: While most of individuals develop neutralizing antibodies within two weeks of infection, the level ofneutralizing activity is significantly decreased over time, highlighting the importance of studying the persistence of neutralizing activity upon natural SARS-CoV-2 infection.

TL;DR: A role for antigenic variation in shaping the humoral immune compartment is described and a rational basis for the hierarchical nature of antibody titers against influenza A viruses in humans is provided.

TL;DR: The data demonstrate that antibody specificity plays an important role in the regulation of ADCC, and that cross-talk among antibodies of varying specificities determines the magnitude of Fc receptor-mediated effector functions.