M
Matthew S. Miller
Researcher at McMaster University
Publications - 102
Citations - 3941
Matthew S. Miller is an academic researcher from McMaster University. The author has contributed to research in topics: Medicine & Virus. The author has an hindex of 25, co-authored 77 publications receiving 2569 citations. Previous affiliations of Matthew S. Miller include McMaster-Carr & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Immunological considerations for COVID-19 vaccine strategies.
Mangalakumari Jeyanathan,Sam Afkhami,Fiona Smaill,Matthew S. Miller,Brian D. Lichty,Zhou Xing +5 more
TL;DR: The immunological principles that need to be taken into consideration in the development of COVID-19 vaccine strategies are discussed and their strengths and potential shortfalls are examined, and inferences about their chances of success are made.
Journal ArticleDOI
Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans
Ali H. Ellebedy,Florian Krammer,Gui-Mei Li,Matthew S. Miller,Christopher Chiu,Jens Wrammert,Cathy Y. Chang,Carl W. Davis,Megan McCausland,Rivka Elbein,Srilatha Edupuganti,Paul Spearman,Sarah F. Andrews,Patrick C. Wilson,Adolfo García-Sastre,Mark J. Mulligan,Aneesh K. Mehta,Peter Palese,Rafi Ahmed +18 more
TL;DR: This study shows that annual influenza vaccines induce antibody responses that are largely directed against the highly variable HA head region, and provides a potential vaccination strategy where heterologous influenza immunization could be used for increasing the levels of broadly neutralizing antibodies and for priming the human population to respond quickly to emerging pandemic influenza threats.
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Cross-Sectional Evaluation of Humoral Responses against SARS-CoV-2 Spike.
Jérémie Prévost,Romain Gasser,Guillaume Beaudoin-Bussières,Jonathan Richard,Ralf Duerr,Annemarie Laumaea,Sai Priya Anand,Guillaume Goyette,Mehdi Benlarbi,Shilei Ding,Halima Medjahed,Antoine Lewin,Josée Perreault,Tony Tremblay,Gabrielle Gendron-Lepage,Nicolas Gauthier,Marc Carrier,Diane Marcoux,Alain Piché,Myriam Lavoie,Alexandre Benoit,Vilayvong Loungnarath,Gino Brochu,Elie Haddad,Hannah D. Stacey,Matthew S. Miller,Marc Desforges,Pierre J. Talbot,Graham T. Gould Maule,Marceline Côté,Christian Therrien,Bouchra Serhir,Renée Bazin,Michel Roger,Andrés Finzi,Andrés Finzi +35 more
TL;DR: While most of individuals develop neutralizing antibodies within two weeks of infection, the level ofneutralizing activity is significantly decreased over time, highlighting the importance of studying the persistence of neutralizing activity upon natural SARS-CoV-2 infection.
Journal ArticleDOI
Neutralizing Antibodies Against Previously Encountered Influenza Virus Strains Increase over Time: A Longitudinal Analysis
Matthew S. Miller,Thomas J. Gardner,Florian Krammer,Lauren C. Aguado,Domenico Tortorella,Christopher F. Basler,Peter Palese +6 more
TL;DR: A role for antigenic variation in shaping the humoral immune compartment is described and a rational basis for the hierarchical nature of antibody titers against influenza A viruses in humans is provided.
Journal ArticleDOI
Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus
Wenqian He,Gene S. Tan,Caitlin E. Mullarkey,Amanda J. Lee,Mannie Man Wai Lam,Florian Krammer,Carole Henry,Patrick C. Wilson,Ali A. Ashkar,Peter Palese,Matthew S. Miller +10 more
TL;DR: The data demonstrate that antibody specificity plays an important role in the regulation of ADCC, and that cross-talk among antibodies of varying specificities determines the magnitude of Fc receptor-mediated effector functions.