Matthieu Desrosiers

TL;DR: The encouraging finding that most state-of-the-art algorithms produce tractograms containing 90% of the ground truth bundles (to at least some extent) is reported, however, the same tractograms contain many more invalid than valid bundles, and half of these invalid bundles occur systematically across research groups.

TL;DR: The results demonstrate fundamental ambiguities inherent to tract reconstruction methods based on diffusion orientation information, with critical consequences for the approach of diffusion tractography in particular and human connectivity studies in general.

TL;DR: An amendment to this paper has been published and can be accessed via a link at the top of the paper.