Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis

Evolution of Protein Molecules

Solid tumours are an enormous cancer burden and a major therapeutic challenge. The cancer stem cell (CSC) hypothesis provides an attractive cellular mechanism to account for the therapeutic refractoriness and dormant behaviour exhibited by many of these tumours. There is increasing evidence that diverse solid tumours are hierarchically organized and sustained by a distinct subpopulation of CSCs. Direct evidence for the CSC hypothesis has recently emerged from mouse models of epithelial tumorigenesis, although alternative models of heterogeneity also seem to apply. The clinical relevance of CSCs remains a fundamental issue but preliminary findings indicate that specific targeting may be possible.

Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

Infectious Diseases Society of America.

MYC on the Path to Cancer

The invention relates to linker peptides, fusion proteins and fusion protein complexes containing them, to processes for the preparation of fusion proteins and to their use. The object of the invention is to provide a flexible linker peptide which, as the result of being used in fusion proteins, yields stable and functionalizable fusion proteins and which can be employed in a modular fashion. To this end, the invention comprises a linker peptide containing an amino acid sequence with at least 10 and not more than 50 amino acids and at least 90%, preferably at least 95%, especially preferably at least 99% amino acid sequence identity to the amino acid sequence according to SEQ ID No. 1. The invention also comprises the use of a linker peptide according to the invention as part of a fusion protein and fusion proteins which contain at least one linker peptide according to the invention and at least one further protein or peptide as fusion partner. Also comprised are fusion protein complexes which contain a fusion protein according to the invention and further molecules bound via domains of the linker peptide. The invention furthermore comprises antibodies or antibody fragments which specifically bind a linker peptide according to the invention, and the use of these antibodies or antibody fragments in fusion proteins.

Linker peptide and its use in fusion proteins

The method involves determining default movement parameter, force and/or torque based on braking requirement of brake devices (40, 42, 44) of a vehicle (12). An electric machine (16) of the vehicle is connected with an electrical energy storage unit (36) and the brake devices, where the electric machine is utilized as a recuperation brake device (38). The movement parameter, the force and/or the torque are limited by a tolerance range. Brake performance of the vehicle is controlled or regulated within the tolerance range based on current maximum recuperation power of the electric machine. The electric machine is designed as a motor-generator, and the electrical energy storage unit is designed as a rechargeable battery. The movement parameter is velocity of the vehicle or distance of the vehicle to a preceding vehicle. An independent claim is also included for a control and/or regulating device for controlling and/or regulating brake performance of a vehicle.

Method for controlling and/or regulating brake performance of motor car, involves limiting movement parameter, force and/or torque, and controlling brake performance within tolerance range based on recuperation power of electric machine

We present results of Monte Carlo computer simulations of a coarse-grained hydrophobic-polar Gō-like heteropolymer model and discuss thermodynamic properties and kinetics of an exemplified heteropolymer, exhibiting two-state folding behavior. It turns out that general, characteristic folding features of realistic proteins with a single free-energy barrier can also be observed in this simplified model, where the folding transition is primarily driven by the hydrophobic force.

Thermodynamics and kinetics of a Gō proteinlike heteropolymer model with two-state folding characteristics

Poly(A) metabolism and aging: a current view.

The invention relates to a method for braking a vehicle which is equipped with a hybrid brake system, wherein in a first phase (P1) of a braking manoeuvre the vehicle is braked by means of a non-hydraulic brake system, and in a later second phase (P2) a hydraulic brake system is activated In order to avoid undesired interruption in the course of the deceleration (a x ) of the vehicle, it is proposed to place the hydraulic brake system in a state of braking readiness in the first phase (P1) As a result, the hydraulic brake system responds directly after activation

Michael Bachmann

Papers

Linker peptide and its use in fusion proteins

Method for controlling and/or regulating brake performance of motor car, involves limiting movement parameter, force and/or torque, and controlling brake performance within tolerance range based on recuperation power of electric machine

Thermodynamics and kinetics of a Gō proteinlike heteropolymer model with two-state folding characteristics

Poly(A) metabolism and aging: a current view.

Method for braking a vehicle having a hybrid brake system