M
Michael Bachmann
Researcher at Helmholtz-Zentrum Dresden-Rossendorf
Publications - 402
Citations - 16252
Michael Bachmann is an academic researcher from Helmholtz-Zentrum Dresden-Rossendorf. The author has contributed to research in topics: Antigen & Chimeric antigen receptor. The author has an hindex of 63, co-authored 360 publications receiving 14388 citations. Previous affiliations of Michael Bachmann include ACADIA Pharmaceuticals Inc. & University of Southern California.
Papers
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Journal ArticleDOI
Interplay between secondary and tertiary structure formation in protein folding cooperativity.
TL;DR: In this article, replica-exchange molecular dynamics simulations of a high-resolution coarse-grained model allow for the accurate evaluation of the density of states in order to extract precise thermodynamic information and measure its impact on structural features.
Patent
Anti-cd33 antibodies and use thereof for immunotargeting in treating cd33-associated illnesses
Michael Bachmann,Slava Stamova +1 more
TL;DR: In this paper, an anti-CD33 antibody is described, which is suitable for use in the field of medicine, pharmaceuticals, and biomedical research using complementary determining regions (CDRs) defined in the claim.
Journal ArticleDOI
CNOB/ChrR6, a new prodrug enzyme cancer chemotherapy
Steve H. Thorne,Yoram Barak,Wenchuan Liang,Michael Bachmann,Jianghong Rao,Christopher H. Contag,Abdul Matin +6 more
TL;DR: The discovery of a new prodrug, 6-chloro-9-nitro-5-oxo-5H-benzo(a)phenoxazine (CNOB), which is efficiently activated by ChrR6, the highly active prodrug activating bacterial enzyme, was effective in killing several cancer cell lines in vitro.
Journal ArticleDOI
Simultaneous engagement of the activatory receptors NKG2D and CD3 for retargeting of effector cells to CD33-positive malignant cells
Slava Stamova,Marc Cartellieri,Anja Feldmann,Claudia C. Bippes,Holger Bartsch,Rebekka Wehner,Marc Schmitz,M von Bonin,Martin Bornhäuser,G. Ehninger,Ernst Peter Rieber,Michael Bachmann +11 more
TL;DR: Simultaneous engagement of the activatory receptors NKG2D and CD3 for retargeting of effector cells to CD33-positive malignant cells is reported.
Journal ArticleDOI
A novel galactose- and arabinose-specific lectin from the sponge Pellina semitubulosa: isolation, characterization and immunobiological properties.
M. Engel,Michael Bachmann,H. C. Schröder,Baruch Rinkevich,Zoran Kljajić,Gerhard Uhlenbruck,W. E. G. Müller +6 more
TL;DR: Immunochemical analyses revealed that both murine T- and B-lymphocytes display a capping of the lectin receptors on their cell surfaces after lectin treatment, and Pellina lectin at concentrations between 0.3 and 10.0 micrograms/ml potently enhances interleukin 1 (IL-1) release from mouse peritoneal macrophages and interLEukin 2 ( IL-2) production in mixed murine lymphocyte cultures.