Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis

Evolution of Protein Molecules

Solid tumours are an enormous cancer burden and a major therapeutic challenge. The cancer stem cell (CSC) hypothesis provides an attractive cellular mechanism to account for the therapeutic refractoriness and dormant behaviour exhibited by many of these tumours. There is increasing evidence that diverse solid tumours are hierarchically organized and sustained by a distinct subpopulation of CSCs. Direct evidence for the CSC hypothesis has recently emerged from mouse models of epithelial tumorigenesis, although alternative models of heterogeneity also seem to apply. The clinical relevance of CSCs remains a fundamental issue but preliminary findings indicate that specific targeting may be possible.

Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

Infectious Diseases Society of America.

MYC on the Path to Cancer




The recombinant antibody AW519 detects specifically the β6 (ITGB6) subunit of αVβ6 integrin on MDA-MB-168 cells and on NIH-3T3 cells when transfected with human β6 integrin as demonstrated with flow cytometry.




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The AW519 antibody specifically detects αvβ6 integrin by flow cytometry

Minute amounts of proteins are required for immunization of mice for the development of antibodies including monoclonal antibodies. Here, we describe a rapid procedure for the isolation of proteins from polyacrylamide gels after sodium dodecyl sulfate polyacrylamide gel electrophoresis in sufficient amounts for immunization of animals.

Isolation of proteins from polyacrylamide gels.

Traditionell spielen Struktur und Mechanismusaufklarungen eine wichtige Rolle in der Biochemie. Richtig zur Sache, namlich in die industrielle Produktion, geht es aber vor allem in der Biotechnologie. Ihr wurde dieses Jahr zum ersten Mal ein eigenes Kapitel gewidmet. Weitere Schwerpunkte: Nucleinsauren, Proteinstrukturen, Immunbiochemie, Bioenergetik, Pathobiochemie, Neurobiochemie sowie Biochemie von Pflanzen und Membranen.

Biochemie und Molekularbiologie 1992

Extracellular Vesicle Imaging Cancer cell‐derived extracellular vesicles (EVs) promote tumor growth and spread. Studying the distribution of EVs in the body is key to understanding cancer progression and developing therapies. In article number 2100055, Masamitsu Kanada and co‐workers develop a highly sensitive EV reporter for tracking heterogeneous EV populations released from cancer cells in live mice.

In Vitro and In Vivo Analysis of Extracellular Vesicle‐Mediated Metastasis Using a Bright, Red‐Shifted Bioluminescent Reporter Protein (Advanced Genetics 1/03)

Michael Bachmann

Papers

The AW519 antibody specifically detects αvβ6 integrin by flow cytometry

Isolation of proteins from polyacrylamide gels.

Biochemie und Molekularbiologie 1992

In Vitro and In Vivo Analysis of Extracellular Vesicle‐Mediated Metastasis Using a Bright, Red‐Shifted Bioluminescent Reporter Protein (Advanced Genetics 1/03)

Synthesis of novel PSMA ligands and preclinical evaluation of [99mTc]TcO-ABX474, a radioligand for SPECT imaging of prostate cancer