M
Michael Bachmann
Researcher at Helmholtz-Zentrum Dresden-Rossendorf
Publications - 402
Citations - 16252
Michael Bachmann is an academic researcher from Helmholtz-Zentrum Dresden-Rossendorf. The author has contributed to research in topics: Antigen & Chimeric antigen receptor. The author has an hindex of 63, co-authored 360 publications receiving 14388 citations. Previous affiliations of Michael Bachmann include ACADIA Pharmaceuticals Inc. & University of Southern California.
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Journal ArticleDOI
Differential effect of insulin and epidermal growth factor on the mRNA translocation system and transport of specific poly(A+) mRNA and poly(A-) mRNA in isolated nuclei.
Heinz-Christoph Schröder,Rosemarie Wenger,D Ugarković,K Friese,Michael Bachmann,W. E. G. Müller +5 more
TL;DR: Studying the mechanism of action of insulin and EGF on NE mRNA translocation system, insulin was found to cause an enhancement of NE-associated phosphoprotein phosphatase activity, resulting in a dephosphorylation of the NE poly(A) binding site (= mRNA carrier) and, hence, in a decrease in its affinity topoly(A).
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Superoxide radical-induced loss of nuclear restriction of immature mRNA: a possible cause for ageing.
TL;DR: The results suggest that cellular ageing may be partially caused by superoxide radical-induced release of immature mRNA from its intranuclear binding site resulting in the appearance of immature messengers in the cytoplasm.
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Generation of single-chain bispecific green fluorescent protein fusion antibodies for imaging of antibody-induced T cell synapses
Slava Stamova,Anja Feldmann,Marc Cartellieri,Claudia Arndt,Stefanie Koristka,Falko Apel,Rebekka Wehner,Marc Schmitz,Martin Bornhäuser,Malte von Bonin,Gerhard Ehninger,Holger Bartsch,Michael Bachmann +12 more
TL;DR: Fluorescent fusion antibodies were useful to efficiently retarget T cells to the respective tumor cells and visualize the formation of immune synapses between effector and target cells.
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Translocation of the nuclear autoantigen La to cell surface: assembly and disassembly with the extracellular matrix.
Michael Bachmann,S.-H. Chang,August Bernd,Werner-Johannes Mayet,K H Meyer zum Büschenfelde,Werner E.G. Müller +5 more
TL;DR: It is reported that La antigen is not restricted to the nucleus as one might deduce from the exclusive nuclear staining pattern of patient anti-La antibodies but after stimulation of serum-starved cells with 10% fetal calf serum appears and stays for at least 45 min at the outer surface of CV-1 cells being available for binding of anti- La antibodies.
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Translocation of the nuclear autoantigen La to the cell surface of herpes simplex virus type 1 infected cells.
TL;DR: It is reported that herpes simplex virus type 1 infection can also induce a translocation of the autoantigen to the cell surface, which could be important in generation of autoimmunity.