M
Michael Bachmann
Researcher at Helmholtz-Zentrum Dresden-Rossendorf
Publications - 402
Citations - 16252
Michael Bachmann is an academic researcher from Helmholtz-Zentrum Dresden-Rossendorf. The author has contributed to research in topics: Antigen & Chimeric antigen receptor. The author has an hindex of 63, co-authored 360 publications receiving 14388 citations. Previous affiliations of Michael Bachmann include ACADIA Pharmaceuticals Inc. & University of Southern California.
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Journal ArticleDOI
Analysis of epitope spreading over an eleven-year period in a patient with systemic lupus erythematosus.
TL;DR: During disease flares anti-Ro/SS A antibodies were upregulated and anti-dsDNA antibodies appeared, thus supporting the concept of an antigen driven intermolecular epitope spreading to Ro/SS-A and dsDNA.
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GD3–7-aldehyde is an apoptosis inducer and interacts with adenine nucleotide translocase
Catherine Brenner,Bernhard Kniep,Evelyne Maillier,Cécile Martel,Claudia Franke,Nadja Röber,Michael Bachmann,Ernst Peter Rieber,Roger Sandhoff +8 more
TL;DR: GD3-7 proved to be more efficient to induce pro-apoptotic mitochondrial alterations than GD3 when tested on mouse liver mitochondria, suggesting that ANT is the molecular target of GD3-3, and might be a novel mediator of PTPC-dependent apoptosis in cancer cells.
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Clinical translation and regulatory aspects of CAR/TCR-based adoptive cell therapies—the German Cancer Consortium approach
Angela M. Krackhardt,Angela M. Krackhardt,Brigitte Anliker,Martin Hildebrandt,Michael Bachmann,Michael Bachmann,Stefan B. Eichmüller,Dirk M. Nettelbeck,Matthias Renner,Lutz Uharek,Lutz Uharek,Gerald Willimsky,Gerald Willimsky,Michael Schmitt,Michael Schmitt,Winfried S. Wels,Winfried S. Wels,Martina Schüssler-Lenz +17 more
TL;DR: This review summarizes the current state of discussions of this cooperative approach providing a basis for further policy-making and suitable modification of processes for clinical translation of CAR/TCR-based cell therapies in Germany.
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Purification and properties of a novel pyrimidine-specific endoribonuclease termed endoribonuclease VII from calf thymus that is modulated by polyadenylate.
TL;DR: Several lines of evidence suggesting a role of endoribonuclease VII in mRNA processing are presented, including a marked affinity for poly(A) and poly(U).
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Targeting Acute Myeloid Leukemia Using the RevCAR Platform: A Programmable, Switchable and Combinatorial Strategy.
Enrico Kittel-Boselli,Enrico Kittel-Boselli,Karla Elizabeth González Soto,Liliana R. Loureiro,Anja Hoffmann,Ralf Bergmann,Ralf Bergmann,Claudia Arndt,Claudia Arndt,Stefanie Koristka,Nicola Mitwasi,Alexandra Kegler,Tabea Bartsch,Nicole Berndt,Heidi Altmann,Frederick Fasslrinner,Martin Bornhäuser,Michael Bachmann,Anja Feldmann +18 more
TL;DR: In this article, a switchable, flexible and programmable adaptor reverse (Rev) CAR platform was proposed to enable combinatorial tumor targeting following Boolean logic gates, and the applicability of the RevCAR platform to target myeloid malignancies like AML was demonstrated.