M
Michael Bachmann
Researcher at Helmholtz-Zentrum Dresden-Rossendorf
Publications - 402
Citations - 16252
Michael Bachmann is an academic researcher from Helmholtz-Zentrum Dresden-Rossendorf. The author has contributed to research in topics: Antigen & Chimeric antigen receptor. The author has an hindex of 63, co-authored 360 publications receiving 14388 citations. Previous affiliations of Michael Bachmann include ACADIA Pharmaceuticals Inc. & University of Southern California.
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Journal ArticleDOI
One gene, two transcripts: isolation of an alternative transcript encoding for the autoantigen La/SS-B from a cDNA library of a patient with primary Sjögrens' syndrome
Helmut Tröster,Thomas E. Metzger,Imre Semsei,Martin Schwemmle,Andreas Winterpacht,Bernhard Zabel,Michael Bachmann +6 more
TL;DR: In the intron, further transcription factor binding sites, including a NF- kappa B element, were identified leading to the suggestion that the expression of the gene encoding for the nuclear autoantigen La/SS-B alters in dependence on disease conditions.
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Bortezomib significantly impairs the immunostimulatory capacity of human myeloid blood dendritic cells
C Straube,Rebekka Wehner,M Wendisch,Martin Bornhäuser,Michael Bachmann,Ernst Peter Rieber,Marc Schmitz +6 more
TL;DR: Evidence is provided that bortezomib significantly reduces the ability of native human blood DCs to regulate innate and adaptive anti-tumor immunity and may have implications for the design of therapeutic strategies combining DC vaccination and bortzomib treatment.
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Identification of La ribonucleoproteins as a component of interchromatin granules.
Maria Carmo-Fonseca,Karin Pfeifer,H. C. Schröder,M. F. Vaz,João Eurico Fonseca,Werner E.G. Müller,Michael Bachmann +6 more
TL;DR: The results demonstrate that La RNPs are localized in clusters of interchromatin granules, both in Triton X-100-extracted and DNase-digested nuclei, suggesting a role for nuclear actin in anchorage of snRNPs.
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Studies on protein kinases involved in regulation of nucleocytoplasmic mRNA transport.
Heinz-Christoph Schröder,Michael Rottmann,Rosemarie Wenger,Michael Bachmann,A. Dorn,W. E. G. Müller +5 more
TL;DR: It is found that phosphorylation of one polypeptide of rat liver envelopes by endogenous NI- and NII-like protein kinase was particularly sensitive to poly(A), which resulted in inhibition of nuclear-envelope NTPase activity and in a concomitant decrease of mRNA (actin) efflux rate from isolated rat liver nuclei.
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The value of synthetic linear epitope analogues of La/SSB for the detection of autoantibodies to La/SSB; specificity, sensitivity and comparison of methods.
E E Yiannaki,A. G. Tzioufas,Michael Bachmann,J Hantoumi,Vassilios Tsikaris,Maria Sakarellos-Daitsiotis,Constantinos Sakarellos,Haralampos M. Moutsopoulos +7 more
TL;DR: The results suggest that the synthetic peptide epitopes exhibit high sensitivity and specificity for the detection of anti‐La/SSB antibodies in ELISA and dot blot techniques.