M
Michael Bachmann
Researcher at Helmholtz-Zentrum Dresden-Rossendorf
Publications - 402
Citations - 16252
Michael Bachmann is an academic researcher from Helmholtz-Zentrum Dresden-Rossendorf. The author has contributed to research in topics: Antigen & Chimeric antigen receptor. The author has an hindex of 63, co-authored 360 publications receiving 14388 citations. Previous affiliations of Michael Bachmann include ACADIA Pharmaceuticals Inc. & University of Southern California.
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Journal ArticleDOI
Localization of antigens PwA33 and La on lampbrush chromosomes and on nucleoplasmic structures in the oocyte of the urodele Pleurodeles waltl: light and electron microscopic immunocytochemical studies.
TL;DR: The results suggest that all the microscopically visible free RNP granules of the nucleoplasm of P. waltl oocytes correspond to B snurposomes and a hitherto undescribed type of submicroscopic granular structure, around 100 nm in either dimension, formed by 10-nm particles is discussed.
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The autoantigen La/SSB: detection on and uptake by mitotic cells.
TL;DR: Staining of living mitotic cells with the anti-La mab La11G7 allowed us to study directly the intranuclear localization of La protein in living cells by the use confocal laser scanning microscopy (cLSM).
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Molecular medicine: the writing is on the vessel wall.
TL;DR: Using an integrated approach, it is possible to identify the molecular addresses on blood-vessel walls that are read by blood cells — and, at least in rats, to deliver imaging agents and drugs to specific tissues.
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Mass spectrometry-based identification of a naturally presented receptor tyrosine kinase-like orphan receptor 1-derived epitope recognized by CD8+ cytotoxic T cells.
Falk Heidenreich,Elke Rücker-Braun,Juliane S. Walz,Anne Eugster,Denise Kühn,Sevina Dietz,Annika Nelde,Antje Tunger,Rebekka Wehner,Cornelia S. Link,Jan Moritz Middeke,Friedrich Stölzel,Torsten Tonn,Stefan Stevanovic,Hans-Georg Rammensee,Hans-Georg Rammensee,Ezio Bonifacio,Michael Bachmann,Matthias Zeis,Gerhard Ehninger,Martin Bornhäuser,Johannes Schetelig,Marc Schmitz +22 more
TL;DR: An emerging immunotherapeutic strategy for CLL is based on the adoptive transfer that addresses the need for additional treatment options for patients with relapsed/refractory high-risk chronic lymphocytic leukemia.
Journal ArticleDOI
T Cell Mediated Conversion of a Non-Anti-La Reactive B Cell to an Autoreactive Anti-La B Cell by Somatic Hypermutation.
Michael Bachmann,Tabea Bartsch,Claudia C. Bippes,Dominik Bachmann,Edinson Puentes-Cala,Jennifer Bachmann,Holger Bartsch,Claudia Arndt,Stefanie Koristka,Liliana R. Loureiro,Alexandra Kegler,Markus Laube,Joanne K Gross,Tim Gross,Biji T. Kurien,R. Hal Scofield,A. Darise Farris,Judith A. James,Marc Schmitz,Marc Schmitz,Anja Feldmann +20 more
TL;DR: In this paper, a series of novel murine anti-La mabs including truly autoreactive ones were derived from a human La transgenic animal through adoptive transfer of T cells from non-transgenic mice immunized with human La antigen.