M
Michael D. W. Griffin
Researcher at University of Melbourne
Publications - 116
Citations - 3042
Michael D. W. Griffin is an academic researcher from University of Melbourne. The author has contributed to research in topics: Fibril & Amyloid. The author has an hindex of 29, co-authored 108 publications receiving 2403 citations. Previous affiliations of Michael D. W. Griffin include University of Canterbury.
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Journal ArticleDOI
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.
Emma J. Petrie,Emma J. Petrie,Jarrod J. Sandow,Jarrod J. Sandow,Annette V. Jacobsen,Annette V. Jacobsen,Brian J. Smith,Michael D. W. Griffin,Isabelle S Lucet,Isabelle S Lucet,Weiwen Dai,Samuel N. Young,Maria C. Tanzer,Maria C. Tanzer,Maria C. Tanzer,Ahmad Wardak,Lung-Yu Liang,Lung-Yu Liang,Angus D. Cowan,Angus D. Cowan,Joanne M Hildebrand,Joanne M Hildebrand,Wilhelmus J A Kersten,Guillaume Lessene,Guillaume Lessene,John Silke,John Silke,Peter E. Czabotar,Peter E. Czabotar,Andrew I. Webb,Andrew I. Webb,James M. Murphy,James M. Murphy +32 more
TL;DR: Evidence is provided that the transition of human MLKL from a monomeric state to a tetramer is essential for necroptosis signalling.
Journal ArticleDOI
Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax
Jakub Gruszczyk,Usheer Kanjee,Li Jin Chan,Li Jin Chan,Sebastien Menant,Benoit Malleret,Benoit Malleret,Nicholas T.Y. Lim,Christoph Q. Schmidt,Yee-Foong Mok,Kai-Min Lin,Richard D. Pearson,Richard D. Pearson,Gabriel W. Rangel,Brian J. Smith,Melissa J. Call,Melissa J. Call,Michael P. Weekes,Michael D. W. Griffin,James M. Murphy,James M. Murphy,Jonathan Abraham,Kanlaya Sriprawat,Maria J. Menezes,Marcelo U. Ferreira,Bruce Russell,Laurent Rénia,Manoj T. Duraisingh,Wai-Hong Tham,Wai-Hong Tham +29 more
TL;DR: Using Brazilian and Thai clinical isolates, data show that TfR1-PvRBP2b invasion pathway is critical for the recognition of reticulocytes during P. vivax invasion.
Journal ArticleDOI
Small Heat-shock Proteins Prevent α-Synuclein Aggregation via Transient Interactions and Their Efficacy Is Affected by the Rate of Aggregation
Dezerae Cox,Dezerae Cox,Emily Selig,Michael D. W. Griffin,John A. Carver,Heath Ecroyd,Heath Ecroyd +6 more
TL;DR: The findings indicate that the rate at which α-syn aggregates in cells may be a significant factor in how it evades sHsp chaperone action in the α- synucleinopathies.
Journal ArticleDOI
Methionine oxidation induces amyloid fibril formation by full-length apolipoprotein A-I
TL;DR: This systematic study of fibrillar formation by full-length apoA-I represents the first demonstration that methionine oxidation can induce amyloid fibril formation.
Journal ArticleDOI
Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen
Benjamin R. Burgess,Renwick C. J. Dobson,Michael F. Bailey,Sarah C. Atkinson,Michael D. W. Griffin,Geoffrey B. Jameson,Michael W. Parker,Michael W. Parker,Juliet A. Gerrard,Matthew A. Perugini +9 more
TL;DR: It is demonstrated for the first time that DHDPS from methicillin-resistant Staphylococcus aureus (MRSA) exists in a monomer-dimer equilibrium in solution and the near atomic resolution crystal structure confirms the dimeric quaternary structure and reveals that the dimerization interface of the MRSA enzyme is more extensive in buried surface area and noncovalent contacts than the equivalent interface in tetrameric D HDPS enzymes from other bacterial species.