M
Michael J. Hynes
Researcher at National University of Ireland, Galway
Publications - 266
Citations - 11221
Michael J. Hynes is an academic researcher from National University of Ireland, Galway. The author has contributed to research in topics: Aspergillus nidulans & Gene. The author has an hindex of 55, co-authored 265 publications receiving 10695 citations. Previous affiliations of Michael J. Hynes include University of Melbourne & National University of Ireland.
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Journal ArticleDOI
Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae
James E. Galagan,Sarah E. Calvo,Christina A. Cuomo,Li-Jun Ma,Jennifer R. Wortman,Serafim Batzoglou,Su-In Lee,Meray Baştürkmen,Christina C. Spevak,John Clutterbuck,Vladimir V. Kapitonov,Jerzy Jurka,Claudio Scazzocchio,Mark L. Farman,Jonathan Butler,Seth Purcell,Steve Harris,Gerhard H. Braus,Oliver W. Draht,Silke Busch,Christophe d'Enfert,Christiane Bouchier,Gustavo H. Goldman,Deborah Bell-Pedersen,Sam Griffiths-Jones,John H. Doonan,Jae-Hyuk Yu,Kay Vienken,Arnab Pain,Michael Freitag,Eric U. Selker,David B. Archer,Miguel A. Peñalva,Berl R. Oakley,Michelle Momany,Toshihiro Tanaka,Toshitaka Kumagai,Kiyoshi Asai,Masayuki Machida,William C. Nierman,David W. Denning,Mark X. Caddick,Michael J. Hynes,Mathieu Paoletti,Reinhard Fischer,Reinhard Fischer,Bruce L. Miller,Paul S. Dyer,Matthew S. Sachs,Stephen A. Osmani,Bruce W. Birren +50 more
TL;DR: The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution, and a comparative study with Aspergillus fumigatus and As pergillus oryzae, used in the production of sake, miso and soy sauce, provides new insight into eukaryotic genome evolution and gene regulation.
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EQNMR : a computer program for the calculation of stability constants from nuclear magnetic resonance chemical shift data
TL;DR: In this article, a computer program has been elaborated which uses the complexation-induced displacements of NMR chemical shifts to calculate the stability constants for the general reaction (i) which gives the generalised stability constant (ii).
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A Versatile and Efficient Gene-Targeting System for Aspergillus nidulans
Tania Nayak,Edyta Szewczyk,C. Elizabeth Oakley,Aysha H. Osmani,Leena Ukil,Sandra L. Murray,Michael J. Hynes,Stephen A. Osmani,Berl R. Oakley +8 more
TL;DR: The A. nidulans homolog (nkuA) of the human KU70 gene that is essential for nonhomologous end joining of DNA in double-strand break repair is identified andletion of nkuA (nukuAΔ) greatly reduces the frequency of nonHomologous integration of transforming DNA fragments, leading to dramatically improved gene targeting.
Journal ArticleDOI
Transformation of Aspergillus niger by the amdS gene of Aspergillus nidulans.
Joan M. Kelly,Michael J. Hynes +1 more
TL;DR: A transformation system is developed for Aspergillus niger using the amdS gene as a dominant heterologous marker for selecting transformants on the basis of acetamide utilization and it is shown that an unselected plasmid can be co‐transformed with the amdR/intA plasmids into A. niger.
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Isolation of genomic clones containing the amdS gene of Aspergillus nidulans and their use in the analysis of structural and regulatory mutations.
TL;DR: The regulatory mutations in the controlling region of the amdS gene were found to be due to small-scale alterations in the DNA rather than to large-scale rearrangements resulting in gene fusions.