M
Michael R. Edwards
Researcher at National Institutes of Health
Publications - 164
Citations - 10111
Michael R. Edwards is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Rhinovirus & Asthma. The author has an hindex of 46, co-authored 158 publications receiving 8887 citations. Previous affiliations of Michael R. Edwards include Imperial College Healthcare & University of Bern.
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Journal ArticleDOI
Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-κB and EGFR pathways.
Christopher A. Hewson,JJ Haas,Nathan W. Bartlett,Simon D. Message,Vasile Laza-Stanca,Tatiana Kebadze,Gaetano Caramori,Jie Zhu,M.R. Edbrooke,Luminita A. Stanciu,Onn Min Kon,Alberto Papi,Peter K. Jeffery,Michael R. Edwards,Sebastian L. Johnston +14 more
TL;DR: Investigating RV induction of MUC5AC in vivo and in vitro identifies targets for development of pharmacologic intervention to treat mucus hypersecretion in RV-induced illness and reveals the complex serial signalling cascade involved.
Journal ArticleDOI
A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13).
Trevor T. Hansel,Tanushree Tunstall,Maria-Belen Trujillo-Torralbo,Maria-Belen Trujillo-Torralbo,Betty Shamji,Ajerico del-Rosario,Ajerico del-Rosario,Jaideep Dhariwal,Jaideep Dhariwal,Paul D. W. Kirk,Michael P. H. Stumpf,Jens Koopmann,Jens Koopmann,Aurica G. Telcian,Julia Aniscenko,Leila Gogsadze,Eteri Bakhsoliani,Luminita A. Stanciu,Nathan W. Bartlett,Michael R. Edwards,Ross P. Walton,Patrick Mallia,Patrick Mallia,Toby Hunt,Trevor Hunt,Duncan Hunt,John Westwick,Matthew J. Edwards,Onn Min Kon,David A. Jackson,Sebastian L. Johnston,Sebastian L. Johnston +31 more
TL;DR: Precision sampling of mucosal lining fluid identifies robust interferon and type 2 responses in the upper and lower airways of asthmatics during an asthma exacerbation.
Journal ArticleDOI
The pathway of arginine catabolism in Giardia intestinalis.
TL;DR: There is no direct metabolic interface between arginine and glucose catabolism in Giardia intestinalis, and the activities of these enzymes are up to 250 fold greater than those reported for the enzymes in Trichomonas vaginalis.
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Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota
Amanda J. McFarlane,Henry J. McSorley,Donald J. Davidson,Paul M. Fitch,Claire Errington,Karen J. Mackenzie,Eva S. Gollwitzer,Chris J. C. Johnston,Andrew S. MacDonald,Michael R. Edwards,Nicola L. Harris,Benjamin J. Marsland,Rick M. Maizels,Jürgen Schwarze +13 more
TL;DR: It is demonstrated that a strictly enteric helminth infection can have remote protective antiviral effects in the lung through induction of a microbiota‐dependent type I interferon response.
Journal ArticleDOI
The role of macrolides in asthma: current evidence and future directions
TL;DR: The evidence from clinical trials is examined, macrolide properties and their relevance to the pathophysiology of asthma are discussed, and the use of macrolides in chronic asthma or acute exacerbations is not justified.