Nora D. Volkow

TL;DR: It is concluded that postsynaptic dopamine receptor availability decreases with chronic cocaine abuse but may recover after a drug-free interval.

TL;DR: It is hypothesised that some of the widespread defects in CBF in the cocaine users could reflect the effects of vasospasm in cerebral arteries exposed chronically to the sympathomimetic actions of cocaine.

TL;DR: In this article, the effects of chronic cocaine intoxication on dopamine receptors in human subjects were evaluated using positron emission tomography (PET) in 10 cocaine abusers and 10 normal control subjects, and the authors concluded that postsynaptic dopamine receptor availability decreases with chronic cocaine abuse but may recover after a drug-free interval.

TL;DR: The factors that triggered the opioids crisis and its further evolution are analyzed, along with the interventions to manage and prevent opioid use disorder (OUD), which are fundamental for curtailing the opioid crisis.

TL;DR: The severity of neuropsychological impairment in cocaine addiction is modest, albeit not indicative of the absence of neurocognitive dysfunction, and compared to other psychopathological disorders, alcohol has a more detrimental effect on Attention/Executive functioning, as assessed with traditional NP measures.