Nora D. Volkow

TL;DR: Findings provide the first evidence that MPH enhances activation of the DAN whereas it alters DMN deactivation, which suggests that MPH modulates cognition in part through its effects on DAN and DMN.

TL;DR: A recent Institute of Medicine-sponsored meeting as discussed by the authors reviewed advances in glutamatergic theories of neuropsychiatric illness as well as remaining barriers to treatment development, highlighting the need not only for improved compounds but also for improved biomarkers sensitive to both structural and functional target engagement and for improved translational models.

TL;DR: The range of dopamine-transporter occupancy required for behavioral activation in the mice was thus similar to that previously reported for experience of a cocaine- or methylphenidate-induced ”high” in human subjects.

TL;DR: The preliminary findings of a higher lung accumulation of methamphetamine in African Americans than Caucasians merits further investigation and questions whether it could contribute to the infrequent use of methamphetamine among African Americans.

TL;DR: It is demonstrated that the functional connectivity of DA pathways matures significantly from childhood to adulthood and is different for healthy children and children with attention-deficit/hyperactivity disorder (ADHD; N = 203; 12 ± 3 years).