Nora D. Volkow

TL;DR: In vitro autoradiography demonstrated that the distribution of binding sites for [123I]AM251 in rat brain was very similar to published distributions of binding Sites for [3H]CP 55,940, suggesting that AM251 binds to the same site (the cannabinoid CB1 receptor) in rodent brains as CP55,940.

TL;DR: A recent Institute of Medicine–sponsored meeting is reviewed, highlighting advances in glutamatergic theories of neuropsychiatric illness as well as remaining barriers to treatment development.

TL;DR: The laterality patterns of short-range and long-range functional connectivity and the gender effects on theseLaterality patterns are studied and it is found that males had greater rightward lateralization of brain connectivity in superior temporal, inferior frontal, and inferior occipital cortices (short-range), whereas females had greater leftward lateralized of long- range connectivity in the inferior frontal cortex.

TL;DR: The results demonstrate that the cannabinoid CB1 receptor is an essential component of the molecular pathways underlying the reinforcing effects of alcohol, and medications targeting the CB1 receptors may be beneficial for the treatment of alcoholism.

TL;DR: Findings of correlational analysis between age and dopamine D2 receptor availability were significant for both ligand and both ligands documented significant age-related decreases in dopamine D 2 receptors that occurred relatively early in life.