Nora D. Volkow

TL;DR: Depressed dopamine activity in caudate and preliminary evidence in limbic regions in adults with ADHD that was associated with inattention and with enhanced reinforcing responses to intravenous methylphenidate suggest that dopamine dysfunction is involved with symptoms of inatt attention but may also contribute to substance abuse comorbidity in ADHD.

TL;DR: The observed association between higher BMI and lower baseline prefrontal metabolism may underlie the impaired performance reported in healthy obese individuals on some cognitive tests of executive function, and the lack of an association between BMI and brain metabolic activation during cognitive stimulation indicates that BMI does not influence brain glucose utilization during cognitive performance.

TL;DR: Stimulant-naïve school-age children with Combined type attention-deficit/hyperactivity disorder were, as a group, larger than expected from norms before treatment but show stimulant-related decreases in growth rates after initiation of treatment, which appeared to reach asymptotes within 3 years without evidence of growth rebound.

TL;DR: It is shown that increases in DRD2 were associated with marked reductions in alcohol preference, and alcohol intake of ethanol preferring rats, which recovered as theDRD2 returned to baseline levels, suggests that high levels of DRD 2 may be protective against alcohol abuse.

TL;DR: The feasibility of using [11C]cocaine and PET to map binding sites for cocaine in human brain, to monitor its kinetics, and to characterize its binding mechanism by using appropriate pharmacological challenges is demonstrated.