N
Nora D. Volkow
Researcher at National Institute on Drug Abuse
Publications - 1038
Citations - 121498
Nora D. Volkow is an academic researcher from National Institute on Drug Abuse. The author has contributed to research in topics: Dopamine & Addiction. The author has an hindex of 165, co-authored 958 publications receiving 107463 citations. Previous affiliations of Nora D. Volkow include National Institutes of Health & North Shore University Hospital.
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Journal ArticleDOI
Regional brain metabolic activation during craving elicited by recall of previous drug experiences.
Gene-Jack Wang,Gene-Jack Wang,Nora D. Volkow,Nora D. Volkow,Joanna S. Fowler,Paula Cervany,Robert Hitzemann,Robert Hitzemann,N. Pappas,Christopher Wong,Christoph Felder +10 more
TL;DR: Activation of the temporal insula, a brain region involved with autonomic control, and of the orbitofrontal cortex, abrain region involvedWith expectancy and reinforcing salience of stimuli, during the cocaine theme support their involvement with craving in cocaine addicted subjects.
Journal ArticleDOI
Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway
Nora D. Volkow,Gene-Jack Wang,Gene-Jack Wang,Jeffrey H. Newcorn,Scott H. Kollins,Timothy Wigal,Frank Telang,Joanna S. Fowler,Joanna S. Fowler,Rita Z. Goldstein,Nelly Klein,Jean Logan,Christopher Wong,James M. Swanson +13 more
TL;DR: Evidence is provided that disruption of the dopamine reward pathway is associated with motivation deficits in ADHD adults, which may contribute to attention deficits and supports the use of therapeutic interventions to enhance motivation in ADHD.
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Role of dopamine in drug reinforcement and addiction in humans: results from imaging studies.
TL;DR: It is shown that during drug intoxication increases in striatal DA are associated with the drug's reinforcing effects only if the DA changes occur rapidly, corroborate the relevance of drug-induced DA increases and of pharmacokinetics in the rewarding effects of drugs in humans.
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Imaging the Effects of Methylphenidate on Brain Dopamine: New Model on Its Therapeutic Actions for Attention-Deficit/Hyperactivity Disorder
TL;DR: The MP's therapeutic effects are postulate to be due in part to its ability to enhance the magnitude of DA increases induced by stimuli that by themselves generate weak responses, enhancing their saliency and the attention and interest they elicit.
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Mechanism of action of methylphenidate: insights from PET imaging studies.
TL;DR: It is postulate that MPH-induced increases In DA could improve attention and decrease distractibility; and that since DA modulates motivation, the increases in DA would also enhance the saliency of the task facilitating the “interest it elicits” and thus improving performance.