R
Rashmi B. Prasad
Researcher at Lund University
Publications - 75
Citations - 4104
Rashmi B. Prasad is an academic researcher from Lund University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 20, co-authored 73 publications receiving 2792 citations. Previous affiliations of Rashmi B. Prasad include University of Helsinki & German Cancer Research Center.
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Journal ArticleDOI
Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables
Emma Ahlqvist,Petter Storm,Annemari Käräjämäki,Mats Martinell,Mozhgan Dorkhan,Annelie Carlsson,Petter Vikman,Rashmi B. Prasad,Dina Mansour Aly,Peter Almgren,Ylva Wessman,Nael Shaat,Peter Spégel,Hindrik Mulder,Eero Lindholm,Olle Melander,Ola Hansson,Ulf Malmqvist,Åke Lernmark,Kaj Lahti,Tom Forsén,Tiinamaija Tuomi,Tiinamaija Tuomi,Anders Rosengren,Anders Rosengren,Leif Groop,Leif Groop +26 more
TL;DR: Five replicable clusters of patients with diabetes were identified, which had significantly different patient characteristics and risk of diabetic complications, which might eventually help to tailor and target early treatment to patients who would benefit most.
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Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism
João Fadista,Petter Vikman,Emilia Ottosson Laakso,Inês G. Mollet,Jonathan L.S. Esguerra,Jalal Taneera,Petter Storm,Peter Osmark,Claes Ladenvall,Rashmi B. Prasad,Karin Hansson,Francesca Finotello,K. Uvebrant,Jones K. Ofori,Barbara Di Camillo,Ulrika Krus,Corrado M. Cilio,Ola Hansson,Lena Eliasson,Anders Rosengren,Erik Renström,Claes B. Wollheim,Claes B. Wollheim,Leif Groop +23 more
TL;DR: The data show that the path from genetic variation (SNP) to gene expression is more complex than hitherto often assumed, and that genetic variation can also influence function of a gene by influencing exon usage or splice isoforms (sQTL), allelic imbalance, RNA editing, and expression of noncoding RNAs.
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Genetics of Type 2 Diabetes—Pitfalls and Possibilities
TL;DR: The possibilities to elucidate the genetic landscape of T2D are addressed as well as pitfalls with current strategies to identify the elusive unknown heritability including the possibility that the definition of diabetes and its subgroups is imprecise and thereby makes the identification of genetic causes difficult.
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Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk
Amy L. Sherborne,Fay J. Hosking,Rashmi B. Prasad,Rajesh Kumar,Rolf Koehler,Jayaram Vijayakrishnan,Elli Papaemmanuil,Claus R. Bartram,Martin Stanulla,Martin Schrappe,Andreas Gast,Sara E. Dobbins,Yussanne Ma,Eamonn Sheridan,Malcolm Taylor,Sally E. Kinsey,T Lightfoot,Eve Roman,Julie Irving,James M. Allan,Anthony V. Moorman,Christine J. Harrison,Ian Tomlinson,Sue Richards,Martin Zimmermann,Csaba Szalai,Ágnes F. Semsei,Dániel J. Erdélyi,Maja Krajinovic,Daniel Sinnett,Jasmine Healy,Anna Gonzalez Neira,Norihiko Kawamata,Seishi Ogawa,H. Phillip Koeffler,Kari Hemminki,Mel Greaves,Richard S. Houlston +37 more
TL;DR: Common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 × 10−11), irrespective of cell lineage.
Journal ArticleDOI
Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood
Rashmi B. Prasad,Fay J. Hosking,Jayaram Vijayakrishnan,Elli Papaemmanuil,Rolf Koehler,Mel Greaves,Eamonn Sheridan,Andreas Gast,Sally E. Kinsey,Tracy Lightfoot,Eve Roman,Malcolm Taylor,Kathy Pritchard-Jones,Martin Stanulla,Martin Schrappe,Claus R. Bartram,Richard S. Houlston,Rajesh Kumar,Kari Hemminki +18 more
TL;DR: The data provide unambiguous evidence for the role of these variants in defining ALL risk underscoring approximately 64% of cases, consistent with a polygenic model of disease susceptibility.