P
Patricia Ruiz Noppinger
Researcher at Charité
Publications - 12
Citations - 1839
Patricia Ruiz Noppinger is an academic researcher from Charité. The author has contributed to research in topics: Estrogen receptor & Regulation of gene expression. The author has an hindex of 12, co-authored 12 publications receiving 1705 citations. Previous affiliations of Patricia Ruiz Noppinger include Max Planck Society.
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Journal ArticleDOI
Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.
Chinmay M. Trivedi,Yang Luo,Yang Luo,Zhan Yin,Zhan Yin,Maozhen Zhang,Maozhen Zhang,Wenting Zhu,Tao Wang,Thomas Floss,Martin Goettlicher,Patricia Ruiz Noppinger,Wolfgang Wurst,Victor A. Ferrari,Charles S. Abrams,Peter J. Gruber,Peter J. Gruber,Jonathan A. Epstein +17 more
TL;DR: It is shown that histone deacetylase-2 (Hdac2) regulates expression of many fetal cardiac isoforms and that Hdac1 and Gsk3β are components of a regulatory pathway providing an attractive therapeutic target for the treatment of cardiac hypertrophy and heart failure.
Journal ArticleDOI
The mammalian gene function resource: the international knockout mouse consortium
Allan Bradley,Konstantinos Anastassiadis,Abdelkader Ayadi,James F. Battey,Cindy Bell,Marie-Christine Birling,Joanna Bottomley,Steve D.M. Brown,Antje Bürger,Carol J. Bult,Wendy Bushell,Francis S. Collins,Christian Desaintes,Brendan Doe,Aris N. Economides,Janan T. Eppig,Richard H. Finnell,Richard H. Finnell,Colin Fletcher,Martin Fray,David Frendewey,Roland H. Friedel,Roland H. Friedel,Frank Grosveld,Jens Hansen,Yann Herault,Geoffrey G. Hicks,Andreas Hörlein,Richard Houghton,Martin Hrabé de Angelis,Danny Huylebroeck,Vivek Iyer,Pieter J. de Jong,James A. Kadin,Cornelia Kaloff,Karen Kennedy,Manousos Koutsourakis,Kevin C K Lloyd,Susan Marschall,Jeremy Mason,Colin McKerlie,Michael P. McLeod,Harald von Melchner,Mark Moore,Alejandro O. Mujica,Alejandro O. Mujica,Andras Nagy,Mikhail Nefedov,Lauryl M. J. Nutter,Guillaume Pavlovic,Jane Peterson,Jonathan D. Pollock,Ramiro Ramirez-Solis,Derrick E. Rancourt,Marcello Raspa,Jacques E. Remacle,Martin Ringwald,Barry Rosen,Nadia Rosenthal,Janet Rossant,Patricia Ruiz Noppinger,Edward Ryder,Joel Schick,Frank Schnütgen,Paul N. Schofield,Claudia Seisenberger,Mohammed Selloum,Elizabeth M. Simpson,William C. Skarnes,Damian Smedley,Damian Smedley,William L. Stanford,A. Francis Stewart,Kevin R. Stone,Kate Swan,Hamsa D. Tadepally,Lydia Teboul,Glauco P. Tocchini-Valentini,David M. Valenzuela,Anthony P. West,Ken Ichi Yamamura,Yuko Yoshinaga,Wolfgang Wurst,Wolfgang Wurst +83 more
TL;DR: The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.
Journal ArticleDOI
Female sex and estrogen receptor-β attenuate cardiac remodeling and apoptosis in pressure overload
Daniela Fliegner,Carola Schubert,A. Penkalla,Henning Witt,Georgios Kararigas,Elke Dworatzek,Eike Staub,Peter Martus,Patricia Ruiz Noppinger,Ulrich Kintscher,Jan-Åke Gustafsson,Vera Regitz-Zagrosek +11 more
TL;DR: Both female sex and ERbeta attenuate the development of fibrosis and apoptosis, thus slowing the progression to heart failure, and the number of apoptotic nuclei was increased in both sexes of ERbeta(-/-)/TAC mice, most prominent in males.
Journal ArticleDOI
A critical review of fundamental controversies in the field of GPR30 research.
Gernot Langer,Benjamin Bader,Luca Meoli,Jörg Isensee,Jörg Isensee,Martina Delbeck,Patricia Ruiz Noppinger,Christiane Otto +7 more
TL;DR: This review revisits the inconsistencies that still exist in the literature and focuses on selected publications that basically address the following two questions: what is the evidence for and against the hypothesis that GPR30 acts as an estrogen receptor?
Journal ArticleDOI
Expression Pattern of G Protein-Coupled Receptor 30 in LacZ Reporter Mice
Jörg Isensee,Luca Meoli,Valeria Zazzu,Christoph S. Nabzdyk,Henning Witt,Dian Soewarto,Karin Effertz,Helmut Fuchs,Valerie Gailus-Durner,Dirk H. Busch,Thure Adler,Martin Hrabé de Angelis,Markus Irgang,Christiane Otto,Patricia Ruiz Noppinger +14 more
TL;DR: The objective of this study was to identify cell types that express GPR30 in vivo by analyzing a mutant mouse model that harbors a lacZ reporter (Gpr30-lacZ) in the Gpr30 locus leading to a partial deletion of the G PR30 coding sequence.