R
Rahul Mannan
Researcher at University of Michigan
Publications - 90
Citations - 1210
Rahul Mannan is an academic researcher from University of Michigan. The author has contributed to research in topics: Cancer & Prostate cancer. The author has an hindex of 12, co-authored 71 publications receiving 630 citations. Previous affiliations of Rahul Mannan include All India Institute of Medical Sciences & University of Health Sciences Antigua.
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Journal ArticleDOI
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
Michael A. Gillette,Michael A. Gillette,Shankha Satpathy,Song Cao,Saravana M. Dhanasekaran,Suhas Vasaikar,Karsten Krug,Francesca Petralia,Yize Li,Wen-Wei Liang,Boris Reva,Azra Krek,Jiayi Ji,Xiaoyu Song,Wenke Liu,Runyu Hong,Lijun Yao,Lili Blumenberg,Sara R. Savage,Michael C. Wendl,Bo Wen,Kai Li,Lauren C. Tang,Lauren C. Tang,Melanie A. MacMullan,Melanie A. MacMullan,Shayan C. Avanessian,M. Harry Kane,Chelsea J. Newton,MacIntosh Cornwell,Ramani B. Kothadia,Weiping Ma,Seungyeul Yoo,Rahul Mannan,Pankaj Vats,Chandan Kumar-Sinha,Emily Kawaler,Tatiana Omelchenko,Antonio Colaprico,Yifat Geffen,Yosef E. Maruvka,Felipe da Veiga Leprevost,Maciej Wiznerowicz,Maciej Wiznerowicz,Zeynep H. Gümüş,Rajwanth R. Veluswamy,Galen Hostetter,David I. Heiman,Matthew A. Wyczalkowski,Tara Hiltke,Mehdi Mesri,Christopher R. Kinsinger,Emily S. Boja,Gilbert S. Omenn,Arul M. Chinnaiyan,Henry Rodriguez,Qing Kay Li,Scott D. Jewell,Mathangi Thiagarajan,Gad Getz,Bing Zhang,David Fenyö,Kelly V. Ruggles,Marcin Cieslik,Ana I. Robles,Karl R. Clauser,Ramaswamy Govindan,Pei Wang,Alexey I. Nesvizhskii,Li Ding,D. R. Mani,Steven A. Carr,Alex Webster,Alicia Francis,Alyssa Charamut,Amanda G. Paulovich,Amy M. Perou,Andrew K. Godwin,Andrii Karnuta,Annette Marrero-Oliveras,Barbara Hindenach,Barbara Pruetz,Bartosz Kubisa,Brian J. Druker,Chet Birger,Corbin D. Jones,Dana R. Valley,Daniel C. Rohrer,Daniel Cui Zhou,Daniel W. Chan,David Chesla,David J. Clark,Dmitry Rykunov,Donghui Tan,Elena V. Ponomareva,Elizabeth R. Duffy,Eric J. Burks,Eric E. Schadt,Erik J. Bergstrom,Eugene S. Fedorov,Ewa P. Malc,George D. Wilson,Hai-Quan Chen,Halina M. Krzystek,Hongwei Liu,Houston Culpepper,Hua Sun,Hui Zhang,Jacob J. Day,James Suh,Jeffrey R. Whiteaker,Jennifer M. Eschbacher,John McGee,Karen A. Ketchum,Karin D. Rodland,Karna Robinson,Katherine A. Hoadley,Kei Suzuki,Ki Sung Um,Kim Elburn,Liang-Bo Wang,Lijun Chen,Linda Hannick,Liqun Qi,Lori J. Sokoll,Małgorzata Wojtyś,Marcin J. Domagalski,Marina A. Gritsenko,Mary Beth Beasley,Matthew E. Monroe,Matthew J. Ellis,Maureen Dyer,Meghan C. Burke,Melissa Borucki,Meng-Hong Sun,Michael H.A. Roehrl,Michael J. Birrer,Michael S. Noble,Michael Schnaubelt,Michael Vernon,Michelle Chaikin,Mikhail Krotevich,Munziba Khan,Myvizhi Esai Selvan,Nancy Roche,Nathan Edwards,Negin Vatanian,Olga Potapova,Pamela Grady,Peter B. McGarvey,Piotr A. Mieczkowski,Pushpa Hariharan,Rashna Madan,Ratna R. Thangudu,Richard D. Smith,Robert J. Welsh,Robert Zelt,Rohit Mehra,Ronald Matteotti,Sailaja Mareedu,Samuel H. Payne,Sandra Cottingham,Sanford P. Markey,Seema Chugh,Shaleigh Smith,Shirley Tsang,Shuang Cai,Simina M. Boca,Sonya Carter,Stacey Gabriel,Stephanie De Young,Stephen E. Stein,Sunita Shankar,Tanya Krubit,Tao Liu,Tara Skelly,Thomas L. Bauer,Uma Velvulou,Umut Ozbek,Vladislav A. Petyuk,Volodymyr Sovenko,William Bocik,William W. Maggio,Xi Chen,Yan Shi,Yige Wu,Yingwei Hu,Yuxing Liao,Zhen Zhang,Zhiao Shi +189 more
TL;DR: Comprehensive proteogenomic characterization of 110 tumors and 101 matched normal adjacent tissues (NATs) incorporating genomics, epigenomics, deep-scale proteomics, phosphoproteomics, and acetylproteomics identified therapeutic vulnerabilities associated with driver events involving KRAS, EGFR, and ALK.
Journal ArticleDOI
Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2 .
Yuanyuan Qiao,Xiaoming Wang,Rahul Mannan,Sethuramasundaram Pitchiaya,Yuping Zhang,Jesse W Wotring,Lanbo Xiao,Dan R. Robinson,Yi-Mi Wu,Jean Ching-Yi Tien,Xuhong Cao,Xuhong Cao,Stephanie A. Simko,Ingrid J. Apel,Pushpinder Bawa,Steven Kregel,Sathiya Pandi Narayanan,Gregory Raskind,Stephanie J. Ellison,Abhijit Parolia,Sylvia Zelenka-Wang,Lisa McMurry,Fengyun Su,Rui Wang,Yunhui Cheng,Andrew D. Delekta,Zejie Mei,Carla D. Pretto,Shaomeng Wang,Rohit Mehra,Jonathan Z. Sexton,Arul M. Chinnaiyan +31 more
TL;DR: It is demonstrated that androgens regulate the expression of ACE2, TMPRSS2, and androgen receptor (AR) in subsets of lung epithelial cells, which support further investigation of transcriptional inhibition of critical host factors in the treatment or prevention of COVID-19.
Journal ArticleDOI
Overexpression of hypoxia-inducible factor and metabolic pathways: possible targets of cancer.
TL;DR: Cancer, the main cause of human deaths in the modern world is a group of diseases and an extensive study on the regulation of each step of these pathways may help find a potential cancer target.
Journal ArticleDOI
Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response
Yuping Zhang,Sathiya Pandi Narayanan,Rahul Mannan,Gregory Raskind,Xiaoming Wang,Pankaj Vats,Fengyun Su,Noshad Hosseini,Xuhong Cao,Chandan Kumar-Sinha,Stephanie J. Ellison,Thomas J. Giordano,Todd M. Morgan,Sethuramasundaram Pitchiaya,Ajjai Alva,Rohit Mehra,Marcin Cieslik,Saravana M. Dhanasekaran,Arul M. Chinnaiyan +18 more
TL;DR: In this article, the authors employed single-cell RNA sequencing (scRNA-seq) to develop benign and malignant renal cell atlases and used a random forest model trained on this cell atlas to predict the putative cell of origin for more than 10 RCC subtypes.
Journal ArticleDOI
Next-generation RNA Sequencing-based Biomarker Characterization of Chromophobe Renal Cell Carcinoma and Related Oncocytic Neoplasms.
Stephanie L. Skala,Xiaoming Wang,Yuping Zhang,Rahul Mannan,Lisha Wang,Sathiya Pandi Narayanan,Pankaj Vats,Fengyun Su,Jin Chen,Xuhong Cao,Javed Siddiqui,Pedram Argani,Marcin Cieślik,Thomas J. Giordano,Arul M. Chinnaiyan,Saravana M. Dhanasekaran,Rohit Mehra +16 more
TL;DR: A pipeline for the identification and validation of RCC subtype-specific biomarkers that can aid in the confirmation of cell of origin and may facilitate accurate classification and diagnosis of renal tumors is demonstrated.