S
Sara R. Savage
Researcher at Baylor College of Medicine
Publications - 27
Citations - 1970
Sara R. Savage is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Proteogenomics & Cancer. The author has an hindex of 11, co-authored 24 publications receiving 677 citations. Previous affiliations of Sara R. Savage include Miami University & Vanderbilt University Medical Center.
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Journal ArticleDOI
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities.
Suhas Vasaikar,Chen Huang,Xiaojing Wang,Vladislav A. Petyuk,Sara R. Savage,Bo Wen,Yongchao Dou,Yun Zhang,Zhiao Shi,Osama A. Arshad,Marina A. Gritsenko,Lisa J. Zimmerman,Jason E. McDermott,Therese R. W. Clauss,Ronald J. Moore,Rui Zhao,Matthew E. Monroe,Yi-Ting Wang,Matthew C. Chambers,Robbert J.C. Slebos,Ken S. Lau,Qianxing Mo,Li Ding,Matthew J. Ellis,Mathangi Thiagarajan,Christopher R. Kinsinger,Henry Rodriguez,Richard D. Smith,Karin D. Rodland,Karin D. Rodland,Daniel C. Liebler,Tao Liu,Bing Zhang,Akhilesh Pandey,Amanda G. Paulovich,Andrew N. Hoofnagle,D. R. Mani,Daniel W. Chan,David F. Ransohoff,David Fenyö,David L. Tabb,Douglas A. Levine,Emily S. Boja,Eric Kuhn,Forest M. White,Gordon Whiteley,Heng Zhu,Hui Zhang,Ie Ming Shih,Jasmin H. Bavarva,Jeffrey R. Whiteaker,Karen A. Ketchum,Karl R. Clauser,Kelly V. Ruggles,Kimberly Elburn,Linda Hannick,Mark A. Watson,Mauricio Oberti,Mehdi Mesri,Melinda E. Sanders,Melissa Borucki,Michael A. Gillette,Michael Snyder,Nathan Edwards,Negin Vatanian,Paul A. Rudnick,Peter B. McGarvey,Philip Mertins,R. Reid Townsend,Ratna R. Thangudu,Robert Rivers,Samuel H. Payne,Sherri R. Davies,Shuang Cai,Stephen E. Stein,Steven A. Carr,Steven J. Skates,Subha Madhavan,Tara Hiltke,Xian Chen,Yingming Zhao,Yue Wang,Zhen Zhang +82 more
TL;DR: Comparative proteomic and phosphoproteomic analysis of paired tumor and normal adjacent tissues produced a catalog of colon cancer-associated proteins and phosphosites, including known and putative new biomarkers, drug targets, and cancer/testis antigens, which suggested glycolysis as a potential target to overcome the resistance of MSI-H tumors to immune checkpoint blockade.
Journal ArticleDOI
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
Michael A. Gillette,Michael A. Gillette,Shankha Satpathy,Song Cao,Saravana M. Dhanasekaran,Suhas Vasaikar,Karsten Krug,Francesca Petralia,Yize Li,Wen-Wei Liang,Boris Reva,Azra Krek,Jiayi Ji,Xiaoyu Song,Wenke Liu,Runyu Hong,Lijun Yao,Lili Blumenberg,Sara R. Savage,Michael C. Wendl,Bo Wen,Kai Li,Lauren C. Tang,Lauren C. Tang,Melanie A. MacMullan,Melanie A. MacMullan,Shayan C. Avanessian,M. Harry Kane,Chelsea J. Newton,MacIntosh Cornwell,Ramani B. Kothadia,Weiping Ma,Seungyeul Yoo,Rahul Mannan,Pankaj Vats,Chandan Kumar-Sinha,Emily Kawaler,Tatiana Omelchenko,Antonio Colaprico,Yifat Geffen,Yosef E. Maruvka,Felipe da Veiga Leprevost,Maciej Wiznerowicz,Maciej Wiznerowicz,Zeynep H. Gümüş,Rajwanth R. Veluswamy,Galen Hostetter,David I. Heiman,Matthew A. Wyczalkowski,Tara Hiltke,Mehdi Mesri,Christopher R. Kinsinger,Emily S. Boja,Gilbert S. Omenn,Arul M. Chinnaiyan,Henry Rodriguez,Qing Kay Li,Scott D. Jewell,Mathangi Thiagarajan,Gad Getz,Bing Zhang,David Fenyö,Kelly V. Ruggles,Marcin Cieslik,Ana I. Robles,Karl R. Clauser,Ramaswamy Govindan,Pei Wang,Alexey I. Nesvizhskii,Li Ding,D. R. Mani,Steven A. Carr,Alex Webster,Alicia Francis,Alyssa Charamut,Amanda G. Paulovich,Amy M. Perou,Andrew K. Godwin,Andrii Karnuta,Annette Marrero-Oliveras,Barbara Hindenach,Barbara Pruetz,Bartosz Kubisa,Brian J. Druker,Chet Birger,Corbin D. Jones,Dana R. Valley,Daniel C. Rohrer,Daniel Cui Zhou,Daniel W. Chan,David Chesla,David J. Clark,Dmitry Rykunov,Donghui Tan,Elena V. Ponomareva,Elizabeth R. Duffy,Eric J. Burks,Eric E. Schadt,Erik J. Bergstrom,Eugene S. Fedorov,Ewa P. Malc,George D. Wilson,Hai-Quan Chen,Halina M. Krzystek,Hongwei Liu,Houston Culpepper,Hua Sun,Hui Zhang,Jacob J. Day,James Suh,Jeffrey R. Whiteaker,Jennifer M. Eschbacher,John McGee,Karen A. Ketchum,Karin D. Rodland,Karna Robinson,Katherine A. Hoadley,Kei Suzuki,Ki Sung Um,Kim Elburn,Liang-Bo Wang,Lijun Chen,Linda Hannick,Liqun Qi,Lori J. Sokoll,Małgorzata Wojtyś,Marcin J. Domagalski,Marina A. Gritsenko,Mary Beth Beasley,Matthew E. Monroe,Matthew J. Ellis,Maureen Dyer,Meghan C. Burke,Melissa Borucki,Meng-Hong Sun,Michael H.A. Roehrl,Michael J. Birrer,Michael S. Noble,Michael Schnaubelt,Michael Vernon,Michelle Chaikin,Mikhail Krotevich,Munziba Khan,Myvizhi Esai Selvan,Nancy Roche,Nathan Edwards,Negin Vatanian,Olga Potapova,Pamela Grady,Peter B. McGarvey,Piotr A. Mieczkowski,Pushpa Hariharan,Rashna Madan,Ratna R. Thangudu,Richard D. Smith,Robert J. Welsh,Robert Zelt,Rohit Mehra,Ronald Matteotti,Sailaja Mareedu,Samuel H. Payne,Sandra Cottingham,Sanford P. Markey,Seema Chugh,Shaleigh Smith,Shirley Tsang,Shuang Cai,Simina M. Boca,Sonya Carter,Stacey Gabriel,Stephanie De Young,Stephen E. Stein,Sunita Shankar,Tanya Krubit,Tao Liu,Tara Skelly,Thomas L. Bauer,Uma Velvulou,Umut Ozbek,Vladislav A. Petyuk,Volodymyr Sovenko,William Bocik,William W. Maggio,Xi Chen,Yan Shi,Yige Wu,Yingwei Hu,Yuxing Liao,Zhen Zhang,Zhiao Shi +189 more
TL;DR: Comprehensive proteogenomic characterization of 110 tumors and 101 matched normal adjacent tissues (NATs) incorporating genomics, epigenomics, deep-scale proteomics, phosphoproteomics, and acetylproteomics identified therapeutic vulnerabilities associated with driver events involving KRAS, EGFR, and ALK.
Journal ArticleDOI
Proteogenomic Characterization of Endometrial Carcinoma.
Yongchao Dou,Emily Kawaler,Daniel Cui Zhou,Marina A. Gritsenko,Chen Huang,Lili Blumenberg,Alla Karpova,Vladislav A. Petyuk,Sara R. Savage,Shankha Satpathy,Wenke Liu,Yige Wu,Chia-Feng Tsai,Bo Wen,Zhi Li,Song Cao,Jamie Moon,Zhiao Shi,MacIntosh Cornwell,Matthew A. Wyczalkowski,Rosalie K. Chu,Suhas Vasaikar,Hua Zhou,Qingsong Gao,Ronald J. Moore,Kai Li,Sunantha Sethuraman,Matthew E. Monroe,Rui Zhao,David I. Heiman,Karsten Krug,Karl R. Clauser,Ramani Kothadia,Yosef E. Maruvka,Alexander R. Pico,Amanda E. Oliphant,Emily L. Hoskins,Samuel L. Pugh,Sean J.I. Beecroft,David W Adams,Jonathan C. Jarman,Andy T. Kong,Hui Yin Chang,Boris Reva,Yuxing Liao,Dmitry Rykunov,Antonio Colaprico,Xi Steven Chen,Andrzej Czekański,Marcin Jędryka,Rafal Matkowski,Maciej Wiznerowicz,Maciej Wiznerowicz,Tara Hiltke,Emily S. Boja,Christopher R. Kinsinger,Mehdi Mesri,Ana I. Robles,Henry Rodriguez,David G. Mutch,Katherine Fuh,Matthew J. Ellis,Deborah DeLair,Mathangi Thiagarajan,D. R. Mani,Gad Getz,Michael S. Noble,Alexey I. Nesvizhskii,Pei Wang,Matthew L. Anderson,Douglas A. Levine,Richard D. Smith,Samuel H. Payne,Kelly V. Ruggles,Karin D. Rodland,Karin D. Rodland,Li Ding,Bing Zhang,Tao Liu,David Fenyö,Anupriya Agarwal,Meenakshi Anurag,Dmitry M. Avtonomov,Chet Birger,Michael J. Birrer,Simina M. Boca,William Bocik,Uma Borate,Melissa Borucki,Meghan C. Burke,Shuang Cai,Anna Calinawan,Steven A. Carr,Sonya Carter,Patricia Castro,Sandra Cerda,Michelle Chaikin,Daniel W. Chan,Doug W. Chan,Alyssa Charamut,Feng Chen,Jin Chen,Lijun Chen,Lin Chen,David Chesla,Milan G. Chheda,Arul M. Chinnaiyan,Shrabanti Chowdhury,Marcin Cieslik,David J. Clark,Sandra Cottingham,Houston Culpepper,Jacob J. Day,Stephanie De Young,Emek Demir,Saravana M. Dhanasekaran,Rajiv Dhir,Marcin J. Domagalski,Peter Dottino,Brian J. Druker,Elizabeth R. Duffy,Maureen Dyer,Nathan Edwards,Robert Edwards,Kim Elburn,Jayson B. Field,Alicia Francis,Stacey Gabriel,Yifat Geffen,Daniel J. Geiszler,Michael A. Gillette,Andrew K. Godwin,Pamela Grady,Linda Hannick,Pushpa Hariharan,Sue Hilsenbeck,Barbara Hindenach,Katherine A. Hoadley,Runyu Hong,Galen Hostetter,James J. Hsieh,Yingwei Hu,Michael Ittmann,Eric J. Jaehnig,Scott D. Jewell,Jiayi Ji,Corbin D. Jones,Renee Karabon,Karen A. Ketchum,Munziba Khan,Beom-Jun Kim,Azra Krek,Tanya Krubit,Chandan Kumar-Sinha,Felipe D. Leprevost,Michael T. Lewis,Qing Kay Li,Yize Li,Hongwei Liu,Jan Lubinski,Weiping Ma,Rashna Madan,Ewa P. Malc,Anna Malovannaya,Sailaja Mareedu,Sanford P. Markey,Annette Marrero-Oliveras,John A. Martignetti,Jason E. McDermott,Peter B. McGarvey,John McGee,Piotr A. Mieczkowski,Francesmary Modugno,Rebecca I. Montgomery,Chelsea J. Newton,Gilbert S. Omenn,Amanda G. Paulovich,Amy M. Perou,Francesca Petralia,Paul D. Piehowski,Larisa Polonskaya,Liqun Qi,Shannon Richey,Karna Robinson,Nancy Roche,Daniel C. Rohrer,Eric E. Schadt,Michael Schnaubelt,Yan Shi,Tara Skelly,Lori J. Sokoll,Xiaoyu Song,Stephen E. Stein,James Suh,Donghui Tan,Darlene Tansil,Guo Ci Teo,Ratna R. Thangudu,Cristina E. Tognon,Elie Traer,Jeffrey W. Tyner,Ki Sung Um,Dana R. Valley,Negin Vatanian,Pankaj Vats,Uma Velvulou,Michael Vernon,Liang-Bo Wang,Ying Wang,Alex Webster,Thomas F. Westbrook,David C. Wheeler,Jeffrey R. Whiteaker,George D. Wilson,Yuriy Zakhartsev,Robert Zelt,Hui Zhang,Yuping Zhang,Zhen Zhang,Grace Zhao +219 more
TL;DR: A comprehensive proteogenomic characterization of endometrial carcinomas revealed possible new consequences of perturbations to the p53 and Wnt/β-catenin pathways, identified a potential role for circRNAs in the epithelial-mesenchymal transition, and provided new information about proteomic markers of clinical and genomic tumor subgroups, including relationships to known druggable pathways.
Journal ArticleDOI
Proteogenomic and metabolomic characterization of human glioblastoma
Liang-Bo Wang,Alla Karpova,Marina A. Gritsenko,Jennifer E. Kyle,Song Cao,Yize Li,Dmitry Rykunov,Antonio Colaprico,Antonio Colaprico,Joseph H. Rothstein,Runyu Hong,Vasileios Stathias,MacIntosh Cornwell,Francesca Petralia,Yige Wu,Boris Reva,Karsten Krug,Pietro Pugliese,Emily Kawaler,Lindsey K. Olsen,Wen-Wei Liang,Xiaoyu Song,Yongchao Dou,Michael C. Wendl,Wagma Caravan,Wenke Liu,Daniel Cui Zhou,Jiayi Ji,Chia-Feng Tsai,Vladislav A. Petyuk,Jamie Moon,Weiping Ma,Rosalie K. Chu,Karl K. Weitz,Ronald J. Moore,Matthew E. Monroe,Rui Zhao,Xiaolu Yang,Xiaolu Yang,Seungyeul Yoo,Azra Krek,Alexis Demopoulos,Houxiang Zhu,Matthew A. Wyczalkowski,Joshua F. McMichael,Brittany Henderson,Caleb M. Lindgren,Hannah Boekweg,Shuangjia Lu,Jessika Baral,Lijun Yao,Kelly L. Stratton,Lisa M. Bramer,Erika M. Zink,Sneha P. Couvillion,Kent J. Bloodsworth,Shankha Satpathy,Weiva Sieh,Simina M. Boca,Stephan C. Schürer,Feng Chen,Maciej Wiznerowicz,Maciej Wiznerowicz,Karen A. Ketchum,Emily S. Boja,Christopher R. Kinsinger,Ana I. Robles,Tara Hiltke,Mathangi Thiagarajan,Alexey I. Nesvizhskii,Bing Zhang,D. R. Mani,Michele Ceccarelli,Xi Chen,Xi Chen,Sandra Cottingham,Qing Kay Li,Albert H. Kim,David Fenyö,Kelly V. Ruggles,Henry Rodriguez,Mehdi Mesri,Samuel H. Payne,Adam C. Resnick,Pei Wang,Richard D. Smith,Antonio Iavarone,Milan G. Chheda,Jill S. Barnholtz-Sloan,Karin D. Rodland,Karin D. Rodland,Tao Liu,Li Ding,Anupriya Agarwal,Mitual Amin,Eunkyung An,Matthew L. Anderson,David W. Andrews,Thomas L. Bauer,Chet Birger,Michael J. Birrer,Lili Blumenberg,William Bocik,Uma Borate,Melissa Borucki,Meghan C. Burke,Shuang Cai,Anna Calinawan,Steven A. Carr,Sandra Cerda,Daniel W. Chan,Alyssa Charamut,Lin Chen,David Chesla,Arul M. Chinnaiyan,Shrabanti Chowdhury,Marcin Cieślik,David J. Clark,Houston Culpepper,Tomasz Czernicki,Fulvio D'Angelo,Jacob J. Day,Stephanie De Young,Emek Demir,Saravana M. Dhanasekaran,Rajiv Dhir,Marcin J. Domagalski,Brian J. Druker,Elizabeth R. Duffy,Maureen Dyer,Nathan Edwards,Robert Edwards,Kimberly Elburn,Matthew J. Ellis,Jennifer M. Eschbacher,Alicia Francis,Stacey Gabriel,Nikolay Gabrovski,Luciano Garofano,Gad Getz,Michael A. Gillette,Andrew K. Godwin,Denis A. Golbin,Ziad Hanhan,Linda Hannick,Pushpa Hariharan,Barbara Hindenach,Katherine A. Hoadley,Galen Hostetter,Chen Huang,Eric J. Jaehnig,Scott D. Jewell,Nan Ji,Corbin D. Jones,Alcida Karz,Wojciech Kaspera,Lyndon Kim,Ramani B. Kothadia,Chandan Kumar-Sinha,Jonathan T. Lei,Felipe D. Leprevost,Kai Li,Yuxing Liao,Jena Lilly,Hongwei Liu,Jan Lubinski,Rashna Madan,William W. Maggio,Ewa P. Malc,Anna Malovannaya,Sailaja Mareedu,Sanford P. Markey,Annette Marrero-Oliveras,Nina Martinez,Nicollette Maunganidze,Jason E. McDermott,Peter B. McGarvey,John McGee,Piotr A. Mieczkowski,Simona Migliozzi,Francesmary Modugno,Rebecca I. Montgomery,Chelsea J. Newton,Gilbert S. Omenn,Umut Ozbek,Oxana Paklina,Amanda G. Paulovich,Amy M. Perou,Alexander R. Pico,Paul D. Piehowski,Dimitris G. Placantonakis,Larisa Polonskaya,Olga Potapova,Barbara Pruetz,Liqun Qi,Shakti Ramkissoon,Adam C. Resnick,Shannon Richey,Gregory J. Riggins,Karna Robinson,Nancy Roche,Daniel C. Rohrer,Brian R. Rood,Larissa Rossell,Sara R. Savage,Eric E. Schadt,Yan Shi,Zhiao Shi,Yvonne Shutack,Shilpi Singh,Tara Skelly,Lori J. Sokoll,Jakub Stawicki,Stephen E. Stein,James Suh,Wojciech Szopa,Dave Tabor,Donghui Tan,Darlene Tansil,Ratna R. Thangudu,Cristina E. Tognon,Elie Traer,Shirley Tsang,Jeffrey W. Tyner,Ki Sung Um,Dana R. Valley,Suhas Vasaikar,Negin Vatanian,Uma Velvulou,Michael Vernon,Weiqing Wan,Junmei Wang,Alex Webster,Bo Wen,Jeffrey R. Whiteaker,George D. Wilson,Yuriy Zakhartsev,Robert Zelt,Hui Zhang,Liwei Zhang,Zhen Zhang,Grace Zhao,Jun Zhu +242 more
TL;DR: This article identified key phosphorylation events (e.g., phosphorylated PTPN11 and PLCG1) as potential switches mediating oncogenic pathway activation, as well as potential targets for EGFR-, TP53-, and RB1-altered tumors.
Journal ArticleDOI
A02 Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
Michael A. Gillette,Shankha Satpathy,Song Cao,Saravana M. Dhanasekaran,Suhas Vasaikar,Karsten Krug,Francesca Petralia,Yize Li,W.-W. Liang,Boris Reva,R. Hong,Sara R. Savage,Gad Getz,Qing Kay Li,Bing Zhang,Henry Rodriguez,Kelly V. Ruggles,Ana I. Robles,K.C. Clauser,Ramaswamy Govindan,Pei Wang,Alexey I. Nesvizhskii,Li Ding,D. R. Mani,Steven A. Carr +24 more