Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
Michael A. Gillette,Michael A. Gillette,Shankha Satpathy,Song Cao,Saravana M. Dhanasekaran,Suhas Vasaikar,Karsten Krug,Francesca Petralia,Yize Li,Wen-Wei Liang,Boris Reva,Azra Krek,Jiayi Ji,Xiaoyu Song,Wenke Liu,Runyu Hong,Lijun Yao,Lili Blumenberg,Sara R. Savage,Michael C. Wendl,Bo Wen,Kai Li,Lauren C. Tang,Lauren C. Tang,Melanie A. MacMullan,Melanie A. MacMullan,Shayan C. Avanessian,M. Harry Kane,Chelsea J. Newton,MacIntosh Cornwell,Ramani B. Kothadia,Weiping Ma,Seungyeul Yoo,Rahul Mannan,Pankaj Vats,Chandan Kumar-Sinha,Emily Kawaler,Tatiana Omelchenko,Antonio Colaprico,Yifat Geffen,Yosef E. Maruvka,Felipe da Veiga Leprevost,Maciej Wiznerowicz,Maciej Wiznerowicz,Zeynep H. Gümüş,Rajwanth R. Veluswamy,Galen Hostetter,David I. Heiman,Matthew A. Wyczalkowski,Tara Hiltke,Mehdi Mesri,Christopher R. Kinsinger,Emily S. Boja,Gilbert S. Omenn,Arul M. Chinnaiyan,Henry Rodriguez,Qing Kay Li,Scott D. Jewell,Mathangi Thiagarajan,Gad Getz,Bing Zhang,David Fenyö,Kelly V. Ruggles,Marcin Cieslik,Ana I. Robles,Karl R. Clauser,Ramaswamy Govindan,Pei Wang,Alexey I. Nesvizhskii,Li Ding,D. R. Mani,Steven A. Carr,Alex Webster,Alicia Francis,Alyssa Charamut,Amanda G. Paulovich,Amy M. Perou,Andrew K. Godwin,Andrii Karnuta,Annette Marrero-Oliveras,Barbara Hindenach,Barbara Pruetz,Bartosz Kubisa,Brian J. Druker,Chet Birger,Corbin D. Jones,Dana R. Valley,Daniel C. Rohrer,Daniel Cui Zhou,Daniel W. Chan,David Chesla,David J. Clark,Dmitry Rykunov,Donghui Tan,Elena V. Ponomareva,Elizabeth R. Duffy,Eric J. Burks,Eric E. Schadt,Erik J. Bergstrom,Eugene S. Fedorov,Ewa P. Malc,George D. Wilson,Hai-Quan Chen,Halina M. Krzystek,Hongwei Liu,Houston Culpepper,Hua Sun,Hui Zhang,Jacob J. Day,James Suh,Jeffrey R. Whiteaker,Jennifer M. Eschbacher,John McGee,Karen A. Ketchum,Karin D. Rodland,Karna Robinson,Katherine A. Hoadley,Kei Suzuki,Ki Sung Um,Kim Elburn,Liang-Bo Wang,Lijun Chen,Linda Hannick,Liqun Qi,Lori J. Sokoll,Małgorzata Wojtyś,Marcin J. Domagalski,Marina A. Gritsenko,Mary Beth Beasley,Matthew E. Monroe,Matthew J. Ellis,Maureen Dyer,Meghan C. Burke,Melissa Borucki,Meng-Hong Sun,Michael H.A. Roehrl,Michael J. Birrer,Michael S. Noble,Michael Schnaubelt,Michael Vernon,Michelle Chaikin,Mikhail Krotevich,Munziba Khan,Myvizhi Esai Selvan,Nancy Roche,Nathan Edwards,Negin Vatanian,Olga Potapova,Pamela Grady,Peter B. McGarvey,Piotr A. Mieczkowski,Pushpa Hariharan,Rashna Madan,Ratna R. Thangudu,Richard D. Smith,Robert J. Welsh,Robert Zelt,Rohit Mehra,Ronald Matteotti,Sailaja Mareedu,Samuel H. Payne,Sandra Cottingham,Sanford P. Markey,Seema Chugh,Shaleigh Smith,Shirley Tsang,Shuang Cai,Simina M. Boca,Sonya Carter,Stacey Gabriel,Stephanie De Young,Stephen E. Stein,Sunita Shankar,Tanya Krubit,Tao Liu,Tara Skelly,Thomas L. Bauer,Uma Velvulou,Umut Ozbek,Vladislav A. Petyuk,Volodymyr Sovenko,William Bocik,William W. Maggio,Xi Chen,Yan Shi,Yige Wu,Yingwei Hu,Yuxing Liao,Zhen Zhang,Zhiao Shi +189 more
TLDR
Comprehensive proteogenomic characterization of 110 tumors and 101 matched normal adjacent tissues (NATs) incorporating genomics, epigenomics, deep-scale proteomics, phosphoproteomics, and acetylproteomics identified therapeutic vulnerabilities associated with driver events involving KRAS, EGFR, and ALK.About:
This article is published in Cell.The article was published on 2020-07-09 and is currently open access. It has received 273 citations till now. The article focuses on the topics: Neutrophil degranulation & Proteogenomics.read more
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Lung Cancer in Never Smokers - Different Disease
TL;DR: Current knowledge of lung cancers arising in never smokers versus smokers is summarized, suggesting that they are separate entities.
Journal ArticleDOI
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy.
Karsten Krug,Eric J. Jaehnig,Shankha Satpathy,Lili Blumenberg,Alla Karpova,Meenakshi Anurag,George Miles,Philipp Mertins,Philipp Mertins,Yifat Geffen,Lauren C. Tang,Lauren C. Tang,David I. Heiman,Song Cao,Yosef E. Maruvka,Jonathan T. Lei,Chen Huang,Ramani B. Kothadia,Antonio Colaprico,Chet Birger,Jarey Wang,Yongchao Dou,Bo Wen,Zhiao Shi,Yuxing Liao,Maciej Wiznerowicz,Maciej Wiznerowicz,Matthew A. Wyczalkowski,Xi Steven Chen,Jacob J. Kennedy,Amanda G. Paulovich,Mathangi Thiagarajan,Christopher R. Kinsinger,Tara Hiltke,Emily S. Boja,Mehdi Mesri,Ana I. Robles,Henry Rodriguez,Thomas F. Westbrook,Li Ding,Gad Getz,Gad Getz,Karl R. Clauser,David Fenyö,Kelly V. Ruggles,Bing Zhang,D. R. Mani,Steven A. Carr,Matthew J. Ellis,Michael A. Gillette,Michael A. Gillette,Shayan C. Avanessian,Shuang Cai,Daniel W. Chan,Xian Chen,Nathan Edwards,Andrew N. Hoofnagle,M. Harry Kane,Karen A. Ketchum,Eric Kuhn,Douglas A. Levine,Shunqiang Li,Daniel C. Liebler,Tao Liu,Jingqin Luo,Subha Madhavan,Christopher G. Maher,Jason E. McDermott,Peter B. McGarvey,Mauricio Oberti,Akhilesh Pandey,Samuel H. Payne,David F. Ransohoff,Robert Rivers,Karin D. Rodland,Paul A. Rudnick,Melinda E. Sanders,Kenna M. Shaw,Ie Ming Shih,Robbert J.C. Slebos,Richard D. Smith,Michael Snyder,Stephen E. Stein,David L. Tabb,Ratna R. Thangudu,Stefani N. Thomas,Yue Wang,Forest M. White,Jeffrey R. Whiteaker,Gordon Whiteley,Hui Zhang,Zhen Zhang,Yingming Zhao,Heng Zhu,Lisa J. Zimmerman +94 more
TL;DR: The integration of mass spectrometry-based proteomics with next-generation DNA and RNA sequencing profiles tumors more comprehensively underscores the potential of proteogenomics for clinical investigation of breast cancer through more accurate annotation of targetable pathways and biological features of this remarkably heterogeneous malignancy.
Journal ArticleDOI
Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression.
Yi-Ju Chen,Theodoros I. Roumeliotis,Ya Hsuan Chang,Ching-Tai Chen,Chia Li Han,Miao-Hsia Lin,Huei-Wen Chen,Gee-Chen Chang,Yih-Leong Chang,Chen-Tu Wu,Mong-Wei Lin,Min Shu Hsieh,Yu Tai Wang,Yet-Ran Chen,Inge Jonassen,Fatemeh Zamanzad Ghavidel,Ze Shiang Lin,Kuen Tyng Lin,Ching Wen Chen,Pei Yuan Sheu,Chen Ting Hung,Ke Chieh Huang,Hao Chin Yang,Pei-Yi Lin,Ta Chi Yen,Yi Wei Lin,Jen-Hung Wang,Lovely Raghav,Lovely Raghav,Chien-Yu Lin,Yan Si Chen,Pei Shan Wu,Chi Ting Lai,Shao Hsing Weng,Kang-Yi Su,Wei Hung Chang,Pang Yan Tsai,Ana I. Robles,Henry Rodriguez,Yi Jing Hsiao,Wen Hsin Chang,Ting-Yi Sung,Jin-Shing Chen,Sung-Liang Yu,Jyoti S. Choudhary,Hsuan-Yu Chen,Hsuan-Yu Chen,Pan-Chyr Yang,Pan-Chyr Yang,Yu-Ju Chen,Yu-Ju Chen +50 more
TL;DR: A deep comprehensive proteogenomic study on a prospectively collected cohort in Taiwan, representing early stage, predominantly female, non-smoking lung adenocarcinoma, revealed the cellular remodeling underpinning clinical trajectories and nominated candidate biomarkers for patient stratification and therapeutic intervention.
Journal ArticleDOI
Targeted Therapies for Lung Cancer Patients With Oncogenic Driver Molecular Alterations
TL;DR: A comprehensive review of the current standards of care for targeted therapies in lung cancer with driver molecular alterations can be found in this article , where the authors discuss the importance of diagnostic molecular testing, intracranial efficacy of novel therapies, optimal sequencing of therapies, role for targeted therapy in early stage disease, and future directions for precision oncology approaches to understand tumor evolution and therapeutic resistance are also discussed.
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