Yuxing Liao

TL;DR: In the 2019 update, WebGestalt supports 12 organisms, 342 gene identifiers and 155 175 functional categories, as well as user-uploaded functional databases and has completely redesigned result visualizations and user interfaces to improve user-friendliness and to provide multiple types of interactive and publication-ready figures.

TL;DR: A hierarchical evolutionary classification of all proteins with experimentally determined spatial structures, and presented as an interactive and updatable online database that catalogs the largest number of evolutionary links among structural domain classifications.

TL;DR: Comprehensive proteogenomic characterization of 110 tumors and 101 matched normal adjacent tissues (NATs) incorporating genomics, epigenomics, deep-scale proteomics, phosphoproteomics, and acetylproteomics identified therapeutic vulnerabilities associated with driver events involving KRAS, EGFR, and ALK.

TL;DR: A large family of potential WRC ligands, consisting of ∼120 diverse membrane proteins, including protocadherins, ROBOs, netrin receptors, neuroligins, GPCRs, and channels, are identified and a sequence motif that defines these ligands binds to a highly conserved interaction surface of the WRC formed by the Sra and Abi subunits.

TL;DR: The use of this method is described to generate structure models for 58 of the 121 large protein families in prokaryotes for which three-dimensional structures are not available, and suggest hypotheses about mechanism for the subset for which the function is known, and hypotheses about function for the remainder.