R
Rainer Breitling
Researcher at University of Manchester
Publications - 239
Citations - 21369
Rainer Breitling is an academic researcher from University of Manchester. The author has contributed to research in topics: Synthetic biology & Metabolomics. The author has an hindex of 65, co-authored 233 publications receiving 19231 citations. Previous affiliations of Rainer Breitling include University of Glasgow & University of Groningen.
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Journal ArticleDOI
antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters
Tilmann Weber,Kai Blin,Srikanth Duddela,Daniel Krug,Hyun Uk Kim,Robert E. Bruccoleri,Sang Yup Lee,Sang Yup Lee,Michael A. Fischbach,Rolf Müller,Wolfgang Wohlleben,Rainer Breitling,Eriko Takano,Marnix H. Medema,Marnix H. Medema +14 more
TL;DR: AntiSMASH as mentioned in this paper is a web server and stand-alone tool for the automatic genomic identification and analysis of biosynthetic gene clusters, available at http://antismash.org.
Journal ArticleDOI
Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments ☆
TL;DR: An analysis of the physiological function of the identified genes indicates that the RP approach is powerful for identifying biologically relevant expression changes and can lead to a sharp reduction in the number of replicate experiments needed to obtain reproducible results.
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antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
Marnix H. Medema,Kai Blin,Peter Cimermancic,Victor de Jager,Victor de Jager,Piotr Zakrzewski,Michael A. Fischbach,Tilmann Weber,Eriko Takano,Rainer Breitling +9 more
TL;DR: This work presents the first comprehensive pipeline capable of identifying biosynthetic loci covering the whole range of known secondary metabolite compound classes, and integrates or cross-links all previously available secondary-metabolite specific gene analysis methods in one interactive view.
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antiSMASH 4.0-improvements in chemistry prediction and gene cluster boundary identification.
Kai Blin,Thomas Wolf,Marc G. Chevrette,Xiaowen Lu,Christopher J. Schwalen,Satria A. Kautsar,Hernando G. Suarez Duran,Emmanuel L. C. de los Santos,Hyun Uk Kim,Mariana Nave,Jeroen S. Dickschat,Douglas A. Mitchell,Ekaterina Shelest,Rainer Breitling,Eriko Takano,Sang Yup Lee,Tilmann Weber,Marnix H. Medema +17 more
TL;DR: The thoroughly updated antiSMASH version 4 is presented, which adds several novel features, including prediction of gene cluster boundaries using the ClusterFinder method or the newly integrated CASSIS algorithm, improved substrate specificity prediction for non-ribosomal peptide synthetase adenylation domains based on the new SANDPUMA algorithm, and several usability features have been updated and improved.
Journal ArticleDOI
antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers
Kai Blin,Marnix H. Medema,Daniyal Kazempour,Michael A. Fischbach,Rainer Breitling,Eriko Takano,Tilmann Weber +6 more
TL;DR: The highly improved antiSMASH 2.0 now supports input of multiple related sequences simultaneously (multi-FASTA/GenBank/EMBL), which allows the analysis of draft genomes comprising multiple contigs, and direct analysis of protein sequences is now possible.