R
Rainer Spang
Researcher at University of Regensburg
Publications - 171
Citations - 11726
Rainer Spang is an academic researcher from University of Regensburg. The author has contributed to research in topics: Gene expression profiling & Diffuse large B-cell lymphoma. The author has an hindex of 48, co-authored 166 publications receiving 10400 citations. Previous affiliations of Rainer Spang include Max Planck Society & Duke University.
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Journal ArticleDOI
Predicting the clinical status of human breast cancer by using gene expression profiles.
Mike West,Carrie Blanchette,Holly K. Dressman,Erich Huang,Seiichi Ishida,Rainer Spang,Harry Zuzan,John A. Olson,Jeffrey R. Marks,Joseph R. Nevins +9 more
TL;DR: Bayesian regression models that provide predictive capability based on gene expression data derived from DNA microarray analysis of a series of primary breast cancer samples are developed and the utility and validity of such models in predicting the status of tumors in crossvalidation determinations are assessed.
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A Biologic Definition of Burkitt's Lymphoma from Transcriptional and Genomic Profiling
Michael Hummel,Stefan Bentink,Hilmar Berger,Wolfram Klapper,Swen Wessendorf,Thomas F. E. Barth,Heinz Wolfram Bernd,Sergio Cogliatti,Judith Dierlamm,Alfred C. Feller,Martin-Leo Hansmann,Eugenia Haralambieva,Lana Harder,Dirk Hasenclever,Michael Kühn,Dido Lenze,Peter Lichter,José I. Martín-Subero,Peter Möller,Hans Konrad Müller-Hermelink,German Ott,Reza Parwaresch,Christiane Pott,Andreas Rosenwald,Maciej Rosolowski,Carsten Schwaenen,Benjamin Stürzenhofecker,Monika Szczepanowski,Heiko Trautmann,Hans Heinrich Wacker,Rainer Spang,Markus Loeffler,Lorenz Trümper,Harald Stein,Reiner Siebert +34 more
TL;DR: The molecular definition of Burkitt's lymphoma clarifies and extends the spectrum of the WHO criteria for Burkitt’s lymphoma.
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Role for E2F in Control of Both DNA Replication and Mitotic Functions as Revealed from DNA Microarray Analysis
Seiichi Ishida,Erich Huang,Harry Zuzan,Rainer Spang,Gustavo Leone,Mike West,Joseph R. Nevins +6 more
TL;DR: High-density DNA microarrays used to provide an analysis of gene regulation during the mammalian cell cycle and the role of E2F in this process identified genes or expressed sequence tags not previously described as regulated by E1F proteins; surprisingly, many of these encode proteins known to function during mitosis.
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Early dissemination seeds metastasis in breast cancer
Hedayatollah Hosseini,Milan Obradovic,Martin Hoffmann,Kathryn Harper,Maria Soledad Sosa,Melanie Werner-Klein,Lahiri Kanth Nanduri,Christian Werno,Carolin Ehrl,Matthias Maneck,Nina Patwary,Gundula Haunschild,Miodrag Gužvić,Christian Reimelt,Michael Grauvogl,Norbert Eichner,Florian Weber,Andreas D. Hartkopf,Florin-Andrei Taran,Sara Y. Brucker,Tanja Fehm,Brigitte Rack,Stefan Buchholz,Rainer Spang,Gunter Meister,Julio A. Aguirre-Ghiso,Christoph Klein,Christoph Klein +27 more
TL;DR: It is shown that progesterone-induced signalling triggers migration of cancer cells from early lesions shortly after HER2 activation, but promotes proliferation in advanced primary tumour cells.
Journal ArticleDOI
Inferring cellular networks – a review
TL;DR: This review gives an overview of computational and statistical methods to reconstruct cellular networks and deals with conditional independence models including Gaussian graphical models and Bayesian networks.