R
Raphael Guerois
Researcher at Université Paris-Saclay
Publications - 141
Citations - 6919
Raphael Guerois is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Homologous recombination & DNA repair. The author has an hindex of 41, co-authored 129 publications receiving 6001 citations. Previous affiliations of Raphael Guerois include Centre national de la recherche scientifique & French Alternative Energies and Atomic Energy Commission.
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The TLCΦ satellite phage harbors a Xer recombination activation factor.
TL;DR: This work brings molecular understanding to the role played by TLCΦ and suggests how similar IMEXs might participate in the evolution of other pathogenic bacteria, as well as showing that integrative mobile elements exploiting Xer (IMEXs) encoding a XafT-like protein are widespread in gamma- and beta-proteobacteria, including human, animal, and plant pathogens.
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Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains
Célia Caillet-Saguy,Angelo Toto,Raphael Guerois,Pierre Maisonneuve,Eva Di Silvio,Kristi Sawyer,Stefano Gianni,Nicolas Wolff +7 more
TL;DR: It is demonstrated here that the linker connecting the PDZ domain and the phosphatase domain is involved in the regulation of theosphatase activity in both PDZ-related inhibition and PDZ ligand-related activation events.
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Dynamics of Ku and bacterial non-homologous end-joining characterized using single DNA molecule analysis.
Robin Öz,Jing L. Wang,Jing L. Wang,Raphael Guerois,Gaurav Goyal,Sriram Kk,Virginie Ropars,Rajhans Sharma,Firat Koca,Jean-Baptiste Charbonnier,Mauro Modesti,Terence R. Strick,Terence R. Strick,Fredrik Westerlund +13 more
TL;DR: In this article, the authors used single-molecule techniques to characterize the dynamics of prokaryotic DNA repair by non-homologous end-joining (NHEJ), a system comprised only of the dimeric Ku and Ligase D (LigD).
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Mean first-passage time analysis reveals rate-limiting steps, parallel pathways and dead ends in a simple model of protein folding
Mille Micheelsen,Christian Rischel,Jesper Ferkinghoff-Borg,Jesper Ferkinghoff-Borg,Raphael Guerois,Luis Serrano +5 more
TL;DR: In this paper, the authors analyzed dynamics on the complex free-energy landscape of protein folding in the FOLD-X model, by calculating for each state of the system the mean first-passage time to the folded state.
Journal ArticleDOI
Mean first passage time analysis reveals rate-limiting steps, parallel pathways and dead ends in a simple model of protein folding
Mille Micheelsen,Christian Rischel,Jesper Ferkinghoff-Borg,Jesper Ferkinghoff-Borg,Raphael Guerois,Luis Serrano +5 more
TL;DR: The resulting kinetic map of the folding process shows that it proceeds in jumps between well-defined, local free-energy minima, and closer analysis of the different local minima allows us to reveal secondary, parallel pathways as well as dead ends.