R
Raphael Guerois
Researcher at Université Paris-Saclay
Publications - 141
Citations - 6919
Raphael Guerois is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Homologous recombination & DNA repair. The author has an hindex of 41, co-authored 129 publications receiving 6001 citations. Previous affiliations of Raphael Guerois include Centre national de la recherche scientifique & French Alternative Energies and Atomic Energy Commission.
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Journal ArticleDOI
The Pif1 helicase is actively inhibited during meiotic recombination which restrains gene conversion tract length.
Dipti Vinayak Vernekar,Giordano Reginato,Giordano Reginato,Céline Adam,Lepakshi Ranjha,Florent Dingli,Marie-Claude Marsolier,Marie-Claude Marsolier,Damarys Loew,Raphael Guerois,Bertrand Llorente,Petr Cejka,Petr Cejka,Valérie Borde +13 more
TL;DR: The authors showed that Pif1's activity that promotes meiotic DNA repair synthesis is restrained by the Mer3-MutLβ ensemble which in turn prevents long gene conversion tracts and possibly associated mutagenesis.
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HMM-Kalign
TL;DR: A tool based on a generalized Viterbi algorithm that generates optimal and sub-optimal alignments between a sequence and a Hidden Markov Model is presented.
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HHalign-Kbest: exploring sub-optimal alignments for remote homology comparative modeling
TL;DR: Improved alignments were systematically generated among the top k suboptimal alignments, which indicates that an optimal alignment by HHsearch may contain small to large errors, leading to poor structure prediction if these errors are located in important structures.
Journal ArticleDOI
Sak4 of Phage HK620 Is a RecA Remote Homolog With Single-Strand Annealing Activity Stimulated by Its Cognate SSB Protein.
Geoffrey Hutinet,Arthur Besle,Olivier Son,Stephen McGovern,Raphael Guerois,Marie-Agnès Petit,Françoise Ochsenbein,François Lecointe +7 more
TL;DR: It is reported that the purified Sak4 of phage HK620 infecting Escherichia coli is a poorly efficient annealase on its own, suggesting that Sak4 could represent a link between two previously distinct types of recombinases that help strand exchange proteins and strand Exchange proteins themselves.
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Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1.
May Bakail,May Bakail,Albane Gaubert,Jessica Andreani,Jessica Andreani,Gwenaëlle Moal,Gwenaëlle Moal,Guillaume Pinna,Guillaume Pinna,Ekaterina Boyarchuk,Ekaterina Boyarchuk,Marie-Cécile Gaillard,Marie-Cécile Gaillard,Régis Courbeyrette,Régis Courbeyrette,Carl Mann,Carl Mann,Jean-Yves Thuret,Jean-Yves Thuret,Berengère Guichard,Brice Murciano,Nicolas Richet,Adeline Poitou,Claire Frederic,Marie-Hélène Le Du,Marie-Hélène Le Du,Morgane Agez,Caroline Roelants,Caroline Roelants,Caroline Roelants,Zachary A. Gurard-Levin,Zachary A. Gurard-Levin,Geneviève Almouzni,Geneviève Almouzni,Nadia Cherradi,Nadia Cherradi,Nadia Cherradi,Raphael Guerois,Raphael Guerois,Françoise Ochsenbein,Françoise Ochsenbein +40 more
TL;DR: A rational design strategy combining epitope tethering and optimization of interface contacts to identify a potent peptide inhibitor with a dissociation constant of 3 nM is developed and it is found that direct injection of the most potent ASF1 peptide inhibitors in mouse allografts reduces tumor growth.