R
Raphael Guerois
Researcher at Université Paris-Saclay
Publications - 141
Citations - 6919
Raphael Guerois is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Homologous recombination & DNA repair. The author has an hindex of 41, co-authored 129 publications receiving 6001 citations. Previous affiliations of Raphael Guerois include Centre national de la recherche scientifique & French Alternative Energies and Atomic Energy Commission.
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Journal ArticleDOI
A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation.
Arnaud de Muyt,Arnaud de Muyt,Alexandra Pyatnitskaya,Alexandra Pyatnitskaya,Jessica Andreani,Jessica Andreani,Lepakshi Ranjha,Claire Ramus,Raphaelle Laureau,Raphaelle Laureau,Ambra Fernandez-Vega,Ambra Fernandez-Vega,Daniel Holoch,Daniel Holoch,Elodie Girard,Jérôme Govin,Raphaël Margueron,Raphaël Margueron,Yohann Couté,Petr Cejka,Petr Cejka,Raphael Guerois,Raphael Guerois,Valérie Borde,Valérie Borde +24 more
TL;DR: The results suggest that the ZZS complex shepherds recombination intermediates toward crossovers as a dynamic structural module that connects recombination events to the chromosome axis.
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Concerted action of the MutLβ heterodimer and Mer3 helicase regulates the global extent of meiotic gene conversion.
Yann Duroc,Yann Duroc,Rajeev Kumar,Rajeev Kumar,Lepakshi Ranjha,Céline Adam,Céline Adam,Raphael Guerois,Khan Md Muntaz,Marie-Claude Marsolier-Kergoat,Marie-Claude Marsolier-Kergoat,Florent Dingli,Raphaelle Laureau,Raphaelle Laureau,Damarys Loew,Bertrand Llorente,Jean-Baptiste Charbonnier,Petr Cejka,Valérie Borde,Valérie Borde +19 more
TL;DR: It is shown that the budding yeast mismatch repair related MutLβ complex, Mlh1-Mlh2, specifically interacts with the conserved meiotic Mer3 helicase, which recruits it to recombination hotspots, independently of mismatch recognition, providing a mechanism for limiting gene conversion in vivo.
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XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
Clément Nemoz,Virginie Ropars,Philippe Frit,Amandine Gontier,Pascal Drevet,Jinchao Yu,Raphael Guerois,Aurelien Pitois,Audrey Comte,Christine Delteil,Nadia Barboule,Pierre Legrand,Sonia Baconnais,Yandong Yin,Satish K. Tadi,Emeline Barbet-Massin,Imre Berger,Eric Le Cam,Mauro Modesti,Eli Rothenberg,Patrick Calsou,Jean-Baptiste Charbonnier +21 more
TL;DR: The Ku70-Ku80 (Ku) heterodimer binds rapidly and tightly to the ends of DNA double-strand breaks and recruits factors of the non-homologous end-joining (NHEJ) repair pathway through molecular interactions that remain unclear.
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InterEvDock: a docking server to predict the structure of protein-protein interactions using evolutionary information.
TL;DR: In 91% of all complexes tested in the benchmark, at least one residue out of the 10 predicted is involved in the interface, providing useful guidelines for mutagenesis, making InterEvDock a unique and efficient tool to explore structural interactomes under an evolutionary perspective.
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Structural and functional analysis of SGT1-HSP90 core complex required for innate immunity in plants.
Yasuhiro Kadota,Béatrice Amigues,Lionel Ducassou,Hocine Madaoui,Françoise Ochsenbein,Raphael Guerois,Ken Shirasu +6 more
TL;DR: A structural model of the HSP90–SGT1 complex is built and a compensatory mutant pair between both partners that is able to restore virus resistance in vivo through Rx (Resistance to potato virus X) immune sensor stabilization is obtained.