R
Rasmus Nielsen
Researcher at University of California, Berkeley
Publications - 594
Citations - 96106
Rasmus Nielsen is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Population & Selection (genetic algorithm). The author has an hindex of 135, co-authored 556 publications receiving 84898 citations. Previous affiliations of Rasmus Nielsen include National Research University – Higher School of Economics & Griffith University.
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Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants
Yingrui Li,Nicolas Vinckenbosch,Geng Tian,Emilia Huerta-Sanchez,Tao Jiang,Hui Jiang,Anders Albrechtsen,Gitte Andersen,Hongzhi Cao,Thorfinn Sand Korneliussen,Niels Grarup,Yiran Guo,Ines Hellman,Xin Jin,Qibin Li,Jiangtao Liu,Xiao Liu,Thomas Sparsø,Meifang Tang,Honglong Wu,Renhua Wu,Chang Yu,Hancheng Zheng,Arne Astrup,Lars Bolund,Lars Bolund,Johan Holmkvist,Torben Jørgensen,Torben Jørgensen,Karsten Kristiansen,Ole Schmitz,Ole Schmitz,Thue W. Schwartz,Xiuqing Zhang,Ruiqiang Li,Huanming Yang,Jing Wang,Torben Hansen,Oluf Pedersen,Oluf Pedersen,Rasmus Nielsen,Rasmus Nielsen,Jun Wang +42 more
TL;DR: Exome sequencing of 200 individuals from Denmark with targeted capture of 18,654 coding genes and sequence coverage of each individual exome at an average depth of 12-fold is reported, suggesting that deleterious substitutions are primarily recessive.
Journal ArticleDOI
Mutation-Selection Models of Codon Substitution and Their Use to Estimate Selective Strengths on Codon Usage
Ziheng Yang,Rasmus Nielsen +1 more
TL;DR: A likelihood ratio test is developed to examine the null hypothesis that codon usage is due to mutation bias alone, not influenced by natural selection, suggesting that natural selection may be a driving force in the evolution of synonymouscodon usage in mammals.
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Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European
Iñigo Olalde,Morten E. Allentoft,Federico Sánchez-Quinto,Gabriel Santpere,Charleston W. K. Chiang,Michael DeGiorgio,Javier Prado-Martinez,Juan Antonio Rodríguez,Simon Rasmussen,Javier Quilez,Oscar Ramirez,Urko M. Marigorta,Marcos Fernandez-Callejo,María E. Prada,Julio Manuel Vidal Encinas,Rasmus Nielsen,Mihai G. Netea,John Novembre,Richard A. Sturm,Pardis C. Sabeti,Tomas Marques-Bonet,Arcadi Navarro,Eske Willerslev,Carles Lalueza-Fox +23 more
TL;DR: An approximately 7,000-year-old Mesolithic skeleton discovered at the La Braña-Arintero site in León, Spain, is sequenceed to retrieve a complete pre-agricultural European human genome, providing evidence that a significant number of derived, putatively adaptive variants associated with pathogen resistance in modern Europeans were already present in this hunter-gatherer.
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Genomic structure in Europeans dating back at least 36,200 years
Andaine Seguin-Orlando,Thorfinn Sand Korneliussen,Martin Sikora,Anna-Sapfo Malaspinas,Andrea Manica,Ida Moltke,Ida Moltke,Anders Albrechtsen,Amy Ko,Ashot Margaryan,Vyacheslav Moiseyev,Ted Goebel,Michael C. Westaway,David M. Lambert,Valeri Khartanovich,Jeffrey D. Wall,Philip R. Nigst,Robert Foley,Robert Foley,Marta Mirazón Lahr,Marta Mirazón Lahr,Rasmus Nielsen,Ludovic Orlando,Eske Willerslev +23 more
TL;DR: The findings reveal the timing of divergence of western Eurasians and East Asians to be more than 36,200 years ago and that European genomic structure today dates back to the Upper Paleolithic and derives from a metapopulation that at times stretched from Europe to central Asia.
Journal ArticleDOI
Postglacial viability and colonization in North America’s ice-free corridor
Mikkel Winther Pedersen,Anthony Ruter,Charles E. Schweger,Harvey Friebe,Richard A. Staff,Kristian K. Kjeldsen,Kristian K. Kjeldsen,Marie Lisandra Zepeda Mendoza,Alwynne B. Beaudoin,Cynthia Zutter,Nicolaj K. Larsen,Nicolaj K. Larsen,Ben A. Potter,Rasmus Nielsen,Rasmus Nielsen,Rebecca A. Rainville,Ludovic Orlando,David J. Meltzer,David J. Meltzer,Kurt H. Kjær,Eske Willerslev,Eske Willerslev,Eske Willerslev +22 more
TL;DR: The findings reveal that the first Americans, whether Clovis or earlier groups in unglaciated North America before 12.6 cal. kyr bp, are unlikely to have travelled by this route into the Americas, however, later groups may have used this north–south passageway.