R
Richard B. Kim
Researcher at University of Western Ontario
Publications - 380
Citations - 33088
Richard B. Kim is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 89, co-authored 328 publications receiving 30436 citations. Previous affiliations of Richard B. Kim include London Health Sciences Centre & St. Jude Children's Research Hospital.
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Journal ArticleDOI
Membrane transporters in drug development.
Kathleen M. Giacomini,Shiew-Mei Huang,Donald J. Tweedie,Leslie Z. Benet,Kim L. R. Brouwer,Xiaoyan Chu,Amber Dahlin,Raymond Evers,Volker Fischer,Kathleen M. Hillgren,Keith Hoffmaster,Toshihisa Ishikawa,Dietrich Keppler,Richard B. Kim,Caroline A. Lee,Mikko Niemi,Joseph W. Polli,Yuicchi Sugiyama,Peter W. Swaan,Joseph A. Ware,Stephen H. Wright,Sook Wah Yee,Maciej J. Zamek-Gliszczynski,Lei Zhang +23 more
TL;DR: Overall, it is advised that the timing of transporter investigations should be driven by efficacy, safety and clinical trial enrolment questions, as well as a need for further understanding of the absorption, distribution, metabolism and excretion properties of the drug molecule, and information required for drug labelling.
Journal ArticleDOI
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.
Richard B. Kim,Martin F. Fromm,Christoph Wandel,Brenda F. Leake,Alastair J. J. Wood,Dan M. Roden,Grant R. Wilkinson +6 more
TL;DR: It is demonstrated that P-glycoprotein limits the oral bioavailability and penetration of these agents into the brain and raises the possibility that higher HIV-1 protease inhibitor concentrations may be obtained by targeted pharmacologic inhibition of P- glycoprotein transport activity.
Journal ArticleDOI
Identification of functionally variant MDR1 alleles among European Americans and African Americans
Richard B. Kim,Richard B. Kim,Brenda F. Leake,Brenda F. Leake,Edna F. Choo,Edna F. Choo,George K. Dresser,George K. Dresser,Samir V. Kubba,Samir V. Kubba,Ute I. Schwarz,Ute I. Schwarz,Amanda Taylor,Amanda Taylor,H. G. Xie,H. G. Xie,Joel McKinsey,Joel McKinsey,Sheng Zhou,Sheng Zhou,Lu-Bin Lan,Lu-Bin Lan,John D. Schuetz,John D. Schuetz,Erin G. Schuetz,Erin G. Schuetz,Grant R. Wilkinson,Grant R. Wilkinson +27 more
TL;DR: Allelic variation in MDR1 is more common than previously recognized and involves multiple SNPs whose allelic frequencies vary between populations, and some of these SNPs are associated with altered P‐glycoprotein function.
Journal ArticleDOI
Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance.
Catia Marzolini,Catia Marzolini,Erik Paus,Erik Paus,Thierry Buclin,Thierry Buclin,Richard B. Kim,Richard B. Kim +7 more
TL;DR: SNPs in MDR1 in relation to population frequencies, drug levels, and phenotypes are outlined and issues relating to M DR1 haplotypes, environmental factors, and study design, as potential confounding factors of the observed MDR 1 polymorphism effect in vivo, are discussed.
Journal ArticleDOI
De novo mutations in histone-modifying genes in congenital heart disease
Samir Zaidi,Murim Choi,Hiroko Wakimoto,Lijiang Ma,Jianming Jiang,John D. Overton,Angela Romano-Adesman,Robert D. Bjornson,Roger E. Breitbart,Kerry K. Brown,Nicholas Carriero,Yee Him Cheung,John E. Deanfield,Steve Depalma,Khalid Adnan Mohamed A. Fakhro,Joseph T. Glessner,Hakon Hakonarson,Michael J. Italia,Jonathan R. Kaltman,Juan Pablo Kaski,Richard B. Kim,Jennie Kline,Teresa Lee,Jeremy Leipzig,Alexander Lopez,Shrikant Mane,Laura E. Mitchell,Jane W. Newburger,Michael Parfenov,Itsik Pe'er,George A. Porter,Amy E. Roberts,Ravi Sachidanandam,Stephen Sanders,Howard S. Seiden,Mathew W. State,Sai Lakshmi Subramanian,Irina Tikhonova,Wei Wang,Wei Wang,Dorothy Warburton,Peter White,Ismee A. Williams,Hongyu Zhao,Jonathan G. Seidman,Martina Brueckner,Wendy K. Chung,Bruce D. Gelb,Elizabeth Goldmuntz,Christine E. Seidman,Richard P. Lifton +50 more
TL;DR: Comparing the incidence of de novo mutations in severe CHD cases and controls by analysing exome sequencing of parent–offspring trios suggests that several hundreds of genes collectively contribute to approximately 10% of severeCHD.