Richard E. Champlin

TL;DR: It is demonstrated that B cells with immunoregulatory properties are enriched within both the CD19(+)IgM(+)CD27(+) memory and CD24(hi)CD38(HI) transitional B-cell subsets in healthy human donors, suggesting that Bregs may be involved in the pathogenesis of cGVHD and support future investigation of regulatory B cell-based therapy in the treatment of this disease.

TL;DR: The presence of anti-DPB1 DSAs is associated with graft failure in MUD hematopoietic stem cell transplantation in patients with matched unrelated donor (MUD) transplantation.

TL;DR: A novel anti-idiotype monoclonal antibody (mAb) to detect CD19-specific CAR+ T cells before and after their adoptive transfer and could be extended to other gene therapy trials targeting different tumor associated antigens in the context of CAR-based adoptive T-cell therapy.

TL;DR: Apheresis of granulocyte‐colony‐stimulating factor (filgrastim)‐mobilized blood stem cells from normal donors is now being used in place of a marrow harvest in transplantation.

TL;DR: Unrelated donor transplantation is a treatment option for older patients with myeloid malignancies and the results in this cohort of patients are comparable with those reported in younger patients with similarly advanced disease.