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Richard E. Champlin
Researcher at University of Texas MD Anderson Cancer Center
Publications - 1500
Citations - 73470
Richard E. Champlin is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 138, co-authored 1402 publications receiving 66917 citations.
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Journal ArticleDOI
Improved Early Outcomes with T-Cell Replete (TCR) Compared with T-Cell Depleted (TCD) Haploidentical Stem Cell Transplantation (HaploSCT)
Stefan O. Ciurea,Rima M. Saliba,Ulas D. Bayraktar,Susan Xie,Gabriela Rondon,Simrit Parmar,Partow Kebriaei,Nivia Montes,Manish Sharma,Marina Konopleva,Yago Nieto,Muzaffar H. Qazilbash,Amin M. Alousi,Borje S. Andersson,Chitra Hosing,Elizabeth J. Shpall,Issa F. Khouri,Marcos de Lima,Richard E. Champlin +18 more
TL;DR: It is hypothesized that TCR HaploSCT using HDPTCy is associated with improved immunologic reconstitution, less NRM and better early outcomes compared with TCD HaPLoSCT, and analyzed 65 consecutive patients treated at UTMDACC.
Posted ContentDOI
Generation of glucocorticoid resistant SARS-CoV-2 T-cells for adoptive cell therapy
Rafet Basar,Nadima Uprety,Emily Ensley,May Daher,Kimberly Klein,Fernando J. Martinez,Fleur M. Aung,Mayra Shanley,Bingqian Hu,Elif Gokdemir,Mayela Mendt,Francia Reyes Silva,Sunil Acharya,Tamara Laskowski,Luis Muniz-Feliciano,Pinaki P. Banerjee,Ye Li,Sufang Li,Luciana Melo Garcia,Paul Lin,Hila Shaim,Sean G. Yates,David Marin,Indreshpal Kaur,Sheetal S Rao,Duncan Mak,Angelique Lin,Qi Miao,Jinzhuang Dou,Ken Chen,Richard E. Champlin,Elizabeth J. Shpall,Katayoun Rezvani +32 more
TL;DR: Since corticosteroids are used for the management of severe COVID-19, a efficient strategy to inactivate the glucocorticoid receptor gene (NR3C1) in SARS-CoV-2 CTLs using CRISPR-Cas9 gene editing is developed.
Journal ArticleDOI
Nonmyeloablative stem cell transplantation for chronic myeloid leukemia.
TL;DR: Nonmyeloablative allogeneic hematopoietic stem cell transplantation shifts tumor eradication to the graft-versus-leukemia effect mediated by donor T lymphocytes, with lower early transplant related mortality and morbidity.
Journal ArticleDOI
Acute graft-versus-host disease is the foremost cause of late nonrelapse mortality
Jeremy Ramdial,Rohtesh S. Mehta,Rima M. Saliba,Amin M. Alousi,Qaiser Bashir,Chitra Hosing,Partow Kebriaei,Amanda Olson,Betul Oran,Muzaffar H. Qazilbash,Samer A. Srour,Borje S. Andersson,Richard E. Champlin,Uday R. Popat +13 more
TL;DR: In this paper, the authors identify factors associated with NRM occurring between days 101 and 365 post-HCT and generate a hypothesis for future studies to reduce the risk of NRM at 1 year.
Journal ArticleDOI
Outcomes of autologous stem cell transplantation in Waldenström's macroglobulinemia.
Neeraj Saini,Romil Patel,Ankur Varma,Qaiser Bashir,Ruby Delgado,Gabriela Rondon,Akash Mukherjee,Uday R. Popat,Chitra Hosing,Yago Nieto,Partow Kebriaei,Donna M. Weber,Sheeba K. Thomas,Hans C. Lee,Elisabet E. Manasanch,Robert Z. Orlowski,Richard E. Champlin,Muzaffar H. Qazilbash,Krina K. Patel +18 more
TL;DR: An updated analysis of the previously published experience with a larger cohort of Waldenström’s macroglobulinemia patients who underwent auto-HCT at MD Anderson Cancer Center is presented.