Richard E. Champlin

TL;DR: Advances in understanding of the HLA system and the development of large international donor registries are supporting the increasing use of unrelated donors as an alternative source of stem cells, however, they are still associated with higher complication rates than in HLA-identical sibling donor transplants.

TL;DR: In this paper, the authors used next-generation sequencing (NGS) to identify the germline mutations in the RNA helicase DDX41, which are associated with increased lifetime risks of myeloid neoplasms with disease often occurring later in life.

TL;DR: The high-dose topotecan, melphalan and cyclophosphamide regimen is well tolerated and produces high response rates and further evaluation of TMC to fully assess response and survival is ongoing.

TL;DR: The regimen of TBI, fludarabine, and melphalan allows the engraftment of allogeneic hematopoietic stem cells (including mismatched CB) and was fairly well tolerated in pediatric patients, even for second transplants.

TL;DR: Temporary placement of a percutaneous nephrostomy catheter relieved the obstruction and significantly improved kidney function, successfully preventing progression to more advanced renal disease in 6 HSCT recipients.