R
Richard E. Champlin
Researcher at University of Texas MD Anderson Cancer Center
Publications - 1500
Citations - 73470
Richard E. Champlin is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 138, co-authored 1402 publications receiving 66917 citations.
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Reduced intensity vs. myeloablative conditioning with fludarabine and PK-guided busulfan in allogeneic stem cell transplantation for patients with AML/MDS.
Gheath Alatrash,Kelly M. Kidwell,Peter F. Thall,Antonio Di Stasi,Julianne Chen,Madhushree Zope,Alyssa K. Crain,Richard E. Champlin,Uday R. Popat,Elizabeth J. Shpall,Roy B. Jones,Borje S. Andersson +11 more
TL;DR: There was a trend toward significantly increased full donor chimerism and decreased chronic graft vs. host disease in RIC, and no significant differences in progression free survival and overall survival between RIC and MAC, and the efficacy of PK-guided-dosing in the setting of allo-SCT for AML and MDS is elucidated.
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Purging: elimination of malignant cells from autologous blood or marrow transplants.
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HLA and TCR Knockout by Zinc Finger Nucleases: Toward “off-the-Shelf” Allogeneic T-Cell Therapy for CD19+ Malignancies.
Hiroki Torikai,Andreas Reik,Carrie Yuen,Yuanyue Zhou,D. Kellar,Helen Huls,Edus H. Warren,Scott S. Tykodi,Philip D. Gregory,Michael C. Holmes,Edward J. Rebar,Dean A. Lee,Richard E. Champlin,Chiara Bonini,Laurence J.N. Cooper +14 more
TL;DR: Whether HLA gene expression can be disrupted by designer zinc-finger nucleases is investigated and plans to develop allogeneic T cells as “off-the-shelf” biologics that can be infused on demand as � “drugs” are developed.
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Pretransplant chest computed tomography screening in asymptomatic patients with leukemia and myelodysplastic syndrome.
Z El Boghdadly,B. Oran,Ying Jiang,Gabriella Rondon,Richard E. Champlin,Dimitrios P. Kontoyiannis +5 more
TL;DR: Pretransplant chest computed tomography screening in asymptomatic patients with leukemia and myelodysplastic syndrome is screened for inoperable leukaemia.
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Impact of graft composition on outcomes of haploidentical bone marrow stem cell transplantation
Rima M. Saliba,Lauren Westfall Veltri,Gabriela Rondon,Julianne Chen,Gheath Alatrash,Amin M. Alousi,Charles Martinez,La Jerald Augustine,Chitra Hosing,Betul Oran,Katayoun Rezvani,Elizabeth J. Shpall,Partow Kebriaei,Issa F. Khouri,Uday R. Popat,Richard E. Champlin,Stefan O. Ciurea +16 more
TL;DR: It is hypothesized that graft composition independently affects the outcomes of haplo-HSCT and graft, donor, and recipient characteristics as predictors of outcomes in a homogeneous population of 147 patients ≥18 years old who received a fresh bone marrow graft.