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Richard E. Champlin
Researcher at University of Texas MD Anderson Cancer Center
Publications - 1500
Citations - 73470
Richard E. Champlin is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 138, co-authored 1402 publications receiving 66917 citations.
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Fifty Years of Melphalan Use in Hematopoietic Stem Cell Transplantation
TL;DR: This review summarizes the development and the current use of this remarkable drug in hematopoietic SCT and suggests melphalan in combination with alemtuzumab may represent a backbone for future cellular therapy because of reliable engraftment and low toxicity profile.
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A prospective randomized trial of buffy coat versus CD34-selected autologous bone marrow support in high-risk breast cancer patients receiving high-dose chemotherapy.
Elizabeth J. Shpall,C. Fred LeMaistre,Kent Holland,Edward D. Ball,Roy B. Jones,Rein Saral,Cindy Jacobs,Shelly Heimfeld,Ronald J. Berenson,Richard E. Champlin +9 more
TL;DR: It is demonstrated that breast cancer patients who receive high-dose therapy with autologous CD34(+) marrow support have reduced marrow infusion-related toxicity, comparable time to neutrophil engraftment and immune function recovery posttransplant, and for women who receive buffy coat fractions of marrow.
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Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells.
Hila Shaim,Mayra Shanley,Rafet Basar,May Daher,Joy Gumin,Daniel Zamler,Nadima Uprety,Fang Wang,Yuefan Huang,Konrad Gabrusiewicz,Qi Miao,Jinzhuang Dou,Abdullah Alsuliman,Lucila Nassif Kerbauy,Sunil Acharya,Vakul Mohanty,Mayela Mendt,Sufang Li,Jun Jun Lu,Jun Wei,Natalie W. Fowlkes,Elif Gokdemir,Emily Ensley,Mecit Kaplan,Cynthia Kassab,Li Li,Gonca Ozcan,Pinaki P. Banerjee,Yifei Shen,April L. Gilbert,Corry M. Jones,Mustafa H Bdiwi,Ana K. Nunez-Cortes,Enli Liu,Jun Yu,Nobuhiko Imahashi,Luis Muniz-Feliciano,Ye Li,Jian Hu,Giulio Draetta,David Marin,Dihua Yu,Stephan Mielke,Matthias Eyrich,Richard E. Champlin,Ken Chen,Frederick F. Lang,Elizabeth J. Shpall,Amy B. Heimberger,Katayoun Rezvani +49 more
TL;DR: The authors showed that GSCs, but not normal astrocytes, are sensitive to lysis by healthy allogeneic natural killer (NK) cells in vitro, and suggested the αv integrin/TGF-β axis as a potentially useful therapeutic target in GBM.
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Drug-induced nephrotoxicity caused by amphotericin B lipid complex and liposomal amphotericin B: a review and meta-analysis.
Amar Safdar,Jonathan Ma,Fouzi Saliba,Bertrand Dupont,John R. Wingard,Ray Y Hachem,Gloria Mattiuzzi,Pranatharthi H. Chandrasekar,Dimitrios P. Kontoyiannis,Kenneth V. I. Rolston,Thomas J. Walsh,Richard E. Champlin,Issam I Raad +12 more
TL;DR: The results suggest that nephrotoxicity is generally similar for ABLC and L-AmB in patients receiving antifungal therapy and prophylaxis in patients treating fungal infections.
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Functional assessment and specific depletion of alloreactive human T cells using flow cytometry
Sergio L.R. Martins,Lisa S. St. John,Richard E. Champlin,Eric D. Wieder,John McMannis,Jeffrey J. Molldrem,Krishna V. Komanduri +6 more
TL;DR: A simple sorting strategy was developed that exploited phenotypic characteristics of T cells responding to allogeneic stimuli to specifically deplete alloreactive T cells while retaining broad specificity for other stimuli, including viral antigens and third-party alloantigens.