Robert J. Gorelick

TL;DR: It is concluded that, as a single agent, 3BNC117 is safe and effective in reducing HIV-1 viraemia, and that immunotherapy should be explored as a new modality for HIV- 1 prevention, therapy and cure.

TL;DR: A single infusion of mAb VRC01 significantly decreased plasma viremia and preferentially suppressed neutralization-sensitive virus strains, demonstrating the virological effect of this neutralizing antibody and highlighting the need for combination strategies to maintain virus suppression.

TL;DR: Results show that clonally expanded CD4+T cells can be a reservoir of infectious HIV-1, and it is reported that a highly expandedCD4+ T-cell clone contains an intact provirus.

TL;DR: The data strongly suggest that the two Zn2+ fingers of HIV-1 are not functionally equivalent and that the first Zn1+ finger in the Gag precursor plays a more prominent role in RNA selection and packaging, and indicate that both Zn 2+ fingers in the mature NC protein play as yet unknown roles in viral assembly or the early stages of the viral infection process.

TL;DR: Initiation of antiretroviral therapy in the first 2 weeks of HIV infection fails to prevent resurgence of virus after stopping treatment, indicating early establishment of a resilient viral reservoir.